Oncologic outcome of CO2 laser surgery for glottic carcinoma

Huang, Zhigang; Han, Demin; Wang, Tong; Zhenkun, Yu; Ni, Xin; Chen, Xiaohong

doi:10.1097/00029330-200603020-00015

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…In our study, the 5-year overall survival rate was 87%, which is similar to that reported by Pradhan 19 (84.1%) and Huang 20 (89.4%). The 5-year DSS rate in our series was 97.5%, similar to reports from other authors such as Eckel 21 and Moreau 13 (97%).…”

Section: Discussionsupporting

confidence: 90%

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Microcirugía transoral con láser para el cáncer glótico temprano en un hospital de tercer nivel en Ciudad de México

Mario¹,

Moreno-Moreno²,

Sánchez-Larios³

et al. 2020

CIRU

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Objective:The objective of the study was to analyze the results of endoscopic laser microsurgery for early glottic carcinoma treatment (Stages I and II) at a Tertiary Center in Mexico City. Materials and methods: Descriptive, retrospective review of 40 patients with early glottic carcinoma who were treated with endoscopic laser microsurgery with curative intent at our institution from November 2003 to December 2013. Results: The study yielded 4 pTis, 19 pT1a, 8 pT1b, and 9 pT2 patients. Mean patient follow-up time was 7.4 years (range 3-12.9 years). Post-operative bleeding requiring surgical intervention occurred in 1 (2.5%) patient. Kaplan-Meier results at 3 and 5-year estimates were as follows: overall survival was 92.5 and 87%, respectively; laser only local control was 94.9 and 91.6%, respectively; and disease specific survival and ultimate local control rate were 97.5% for both time periods. We found a 97.5% (39/40) organ preservation rate. Conclusions: Laser microsurgery for glottic carcinoma treatment is an emerging technique in Mexico. Our results are promising as reported by other authors in Europe and United States of America, which support the replicability of the surgical technique refined by Dr. Wolfgang Steiner.

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Section: Discussionsupporting

confidence: 90%

“…The 5-year laser alone local control of our cohort was 91.6% while it has been reported in 93% in different series 14,20,21 , our 5-year ULC was 97.5%, where as we found a 98.7%14,20,21,25,26 reported in the literature. Fortunately, we gladly found that our results are similar as other experienced authors have reported 24,27,28 (Table 2).…”

Section: Discussionsupporting

confidence: 53%

Microcirugía transoral con láser para el cáncer glótico temprano en un hospital de tercer nivel en Ciudad de México

Mario¹,

Moreno-Moreno²,

Sánchez-Larios³

et al. 2020

CIRU

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“…The authors concluded that surgery could only be performed in select T1 and T2 tumors. 10 In 2006, Huang et al 13 described a similar series of 217 patients. The series contained only 3 T3 carcinomas and no T4 carcinomas.…”

Section: Complicationsmentioning

confidence: 99%

“…The series contained only 3 T3 carcinomas and no T4 carcinomas. 13 In contrast, some authors [4][5][6]12 have expanded the use of TLM to include both advanced-stage laryngeal and other head and neck cancers. In the past decade, there has been a shift toward nonsurgical management of advanced laryngeal cancer.…”

Section: Complicationsmentioning

confidence: 99%

Transoral Laser Microsurgery for Advanced Laryngeal Cancer

Hinni

Salassa

Grant

et al. 2007

Arch Otolaryngol Head Neck Surg

178

127

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Patients: A total of 117 patients with pathologically confirmed T2 to T4 lesions, stage III or stage IV, glottic or supraglottic carcinoma of the larynx were treated with TLM from 1997 to 2004. All patients had a minimum follow-up period of 2 years. Interventions: Transoral laser microsurgery in 117 patients, neck dissection in 91 patients, and adjuvant radiotherapy in 45 patients. Main Outcome Measures: End points analyzed included laryngeal preservation, overall survival, diseasefree survival, local control, locoregional control, and distant metastases. Postoperative complications, tracheotomy rate, and feeding-tube dependence were also examined. Results: The median follow-up period among surviving patients was 5 years. At 2 years, the percentage of patients with an intact larynx after treatment was 92%. The 2-year local control and locoregional control rates were 82% and 77%, respectively. The 2-year disease-free and overall survival rates were 68% and 75%, respectively. The 5-year Kaplan-Meier estimates were local control, 74%; locoregional, control, 68%; disease-free survival, 58%; overall survival, 55%; and distant metastases, 14%. Four patients (3%) experienced treatment-related deaths. Seven patients (6%) experienced a postoperative hemorrhage. Of those patients with organ preservation and no disease recurrence, 2 patients (3%) were tracheotomy dependent, and 4 patients (7%) were feedingtube dependent. Conclusions: In patients with advanced laryngeal cancer, TLM with or without radiotherapy is a valid treatment strategy for organ preservation. Furthermore, low morbidity and mortality and excellent oncologic and functional outcomes make TLM an attractive therapeutic option.

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“…15 Transoral resection with the CO 2 laser has a limited role in the management of T 2 glottic cancer. 16 It is only appropriate for lesions that are superficially infiltrative and do not involve the anterior commissure. A typical example is a glottic cancer extending posteriorly and superiorly onto the mucosa of the arytenoid.…”

Section: T 2 Glottic Cancermentioning

confidence: 99%

Treatment Decision in the Management of Laryngeal Cancer: An Overview

Pradhan¹,

Kannan²

2010

An International Journal of Otorhinolaryngology Clinics

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A spectrum of treatment plans and surgical procedures are available for management of laryngeal cancer. Transoral laser resection has proved an effective, minimally invasive and functionally satisfactory procedure for management of suitable T1 and T2 glottic cancers, and stage I-III supraglottic cancers. Introduction of chemoradiotherapy has also made great impact on the laryngeal preservation. The treatment of laryngeal cancer should be individualized according to the size and extent of the tumor, the age and physical condition of the patient, and the skill and experience of the surgeon with various treatment modalities and surgical procedures.

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Oncologic outcome of CO2 laser surgery for glottic carcinoma

Cited by 5 publications

References 8 publications

Microcirugía transoral con láser para el cáncer glótico temprano en un hospital de tercer nivel en Ciudad de México

Microcirugía transoral con láser para el cáncer glótico temprano en un hospital de tercer nivel en Ciudad de México

Transoral Laser Microsurgery for Advanced Laryngeal Cancer

Treatment Decision in the Management of Laryngeal Cancer: An Overview

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