Oncologic long-term outcomes of emergency versus elective resection for colorectal cancer

Lavanchy, Joël L.; Vaisnora, Lukas; Haltmeier, Tobias; Zlobec, Inti; Brügger, Lukas; Candinas, Daniel; Schnüriger, Beat

doi:10.1007/s00384-019-03426-8

Cited by 35 publications

(40 citation statements)

References 26 publications

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“…Emergency surgery for localized colon cancer is associated with a greater risk of recurrence and death 7‐10 . This may be related to higher in‐hospital mortality after surgery and to a more advanced cancer stage at the time of diagnosis 11 . Primary delay and the increase in patients seen in the emergency setting may be related.…”

Section: Discussionmentioning

confidence: 99%

Impact of the COVID‐19 pandemic during Spain's state of emergency on the diagnosis of colorectal cancer

Suárez

Mata

Guerra

et al. 2020

Journal of Surgical Oncology

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Introduction: We evaluate the impact of COVID-epidemic in colorectal cancer (CRC) diagnosis during Spain's state of emergency. Methods: We compared newly diagnosed patients with patients diagnosed in the same period of 2019. Results: A new diagnosis of CRC decreased 48% with a higher rate of patients diagnosed in the emergency setting (12.1% vs. 3.6%; p = .048) and a lower rate diagnosed in the screening program (5.2% vs. 33.3%; p = .000). Conclusions: Fewer patients have been diagnosed with CRC, with a higher rate of patients diagnosed in an emergency setting.

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Section: Discussionmentioning

confidence: 99%

Impact of the COVID‐19 pandemic during Spain's state of emergency on the diagnosis of colorectal cancer

Suárez

Mata

Guerra

et al. 2020

Journal of Surgical Oncology

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“…The MSKCC results from two time periods described above illustrate the changes seen with time [38]. In hospital-based series, recurrence rates in the order of 10-20% (/FFR/TTR rates 80-90% after 5 years) have been reported in patients operated about 10-20 years ago [55,138,[140][141][142][143][144]151]. In most studies, some patients received adjuvant therapy, but several hospitals gave no adjuvant therapy [138,140,144,145] (Table 6).…”

Section: Predominantly Colon Cancermentioning

confidence: 93%

Recurrence Risk after Radical Colorectal Cancer Surgery—Less Than before, But How High Is It?

Osterman

Hammarström

Imam

et al. 2020

Cancers

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Adjuvant chemotherapy aims at eradicating tumour cells sometimes present after radical surgery for a colorectal cancer (CRC) and thereby diminish the recurrence rate and prolong time to recurrence (TTR). Remaining tumour cells will lead to recurrent disease that is usually fatal. Adjuvant therapy is administered based upon the estimated recurrence risk, which in turn defines the need for this treatment. This systematic overview aims at describing whether the need has decreased since trials showing that adjuvant chemotherapy provides benefits in colon cancer were performed decades ago. Thanks to other improvements than the administration of adjuvant chemotherapy, such as better staging, improved surgery, the use of radiotherapy and more careful pathology, recurrence risks have decreased. Methodological difficulties including intertrial comparisons decades apart and the present selective use of adjuvant therapy prevent an accurate estimate of the magnitude of the decreased need. Furthermore, most trials do not report recurrence rates or TTR, only disease-free and overall survival (DFS/OS). Fewer colon cancer patients, particularly in stage II but also in stage III, today display a sufficient need for adjuvant treatment considering the burden of treatment, especially when oxaliplatin is added. In rectal cancer, neo-adjuvant treatment will be increasingly used, diminishing the need for adjuvant treatment.

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“…Overall survival and median disease-free survival were not statistically different, 72.4 versus 78.9%, (p ¼ 0.257), again showing that recurrence was based on stage and not the nature of the case. 56 To better understand this negative effect further studies were done to determine prognostic factors that might help direct therapy. Manceau et al studied outcomes of over 2,000 patients treated for obstructive colon cancer.…”

Section: Outcomes For Malignant Obstructing Colon Cancermentioning

confidence: 99%

Malignant Large Bowel Obstruction

Muldoon

2021

Clin Colon Rectal Surg

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Large bowel obstruction is a serious and potentially life-threatening surgical emergency which is associated with high morbidity and mortality rate. The most common etiology is colorectal cancer which accounts for over 60% of all large bowel obstructions. Proper assessment, thoughtful decision-making and prompt treatment is necessary to decrease the high morbidity and mortality which is associated with this entity. Knowledge of the key elements regarding the presentation of a patient with a large bowel obstruction will help the surgeon in formulating an appropriate treatment plan for the patient. Comprehensive knowledge and understanding of the various treatment options available is necessary when caring for these patients. This chapter will review the presentation of patients with malignant large bowel obstruction, discuss the various diagnostic modalities available, as well as discuss treatment options and the various clinical scenarios in which they are most appropriately utilized.

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Oncologic long-term outcomes of emergency versus elective resection for colorectal cancer

Cited by 35 publications

References 26 publications

Impact of the COVID‐19 pandemic during Spain's state of emergency on the diagnosis of colorectal cancer

Impact of the COVID‐19 pandemic during Spain's state of emergency on the diagnosis of colorectal cancer

Recurrence Risk after Radical Colorectal Cancer Surgery—Less Than before, But How High Is It?

Malignant Large Bowel Obstruction

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