“…Distant disease is less frequent (20%-40%), but metastases to the bone, lung, liver, lymph-nodes and skin have been described [3, 4, 5, 6, 7]. The 10-year overall survival (OS) rate ranges from 30% to 65% [5, 7, 8, 9, 10, 11, 12]. Radical surgery is the only hope for cure as no chemotherapy has been demonstrated to be effective against a chordoma, and radiotherapy is only marginally effective [5, 7, 9, 13, 14, 15].…”