Oncogenicity of the Simian Adenoviruses

Abstract

Five of 17 adenoviruses of rhesus or cynomolgus monkey origin induced tumors in newborn hamsters. The tumors appeared between 42 and 280 days after subcutaneous inoculation and had the general characteristics of lymphomas. The tumors were specific by cross-complement fixation tests. An adenovirus recovered from Cercopithecus monkeys appeared to be highly oncogenic; all 23 inoculated hamsters developed tumors within 30 to 40 days.

The Oncogenicity of Human Adenoviruses in Hamsters

“…Human adenovirus types 18, 7, 31, and 3 have also been reported to induce undifferentiated tumors, lymphomas, and lymphosarcomas in newborn hamsters (16)(17)(18)(19). Green et al ( ademviruses tested were also omogenic in newborn hamsters, some of them highly once genic (20). The tumors induced were undifferentiated with some characteristics of lymphomas of the reticulum d l type.…”

Pathogenesis of oncogenic simian adenoviruses. IV. The histopathology and ultrastructure of intraperitoneal neoplasms induced by SV20

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The histopathology and ultrastructure of S V2O-induced intraperitoneal ( I P ) neoplasms is described and compared to neoplasms induced by this virus administered bySeveral simian adenoviruses are oncogenic for the hamster (Hull et al, 1965; Rapoza et al, 1967;Slifkin et al, 1968; Merkow et al, 1968a, b). The ability of simian adenovirus 20 (SV20) to initiate neoplasms capable of metastasizing appears to vary according to the route of inoculation.

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Transformation of Rodent Cells by Simian Adenovirus SA-7

“…Simian adenovirus SA-7 is highly oncogenic in hamsters ( 1 ) and transforms mouse, hamster, and rat cells in vitro (2)(3)(4). When assayed in primary hamster embryo cell cultures, SA-7 transforms the cells more efficiently [has a lower plaque-forming unit (PFU) to focus-forming unit (FFU) ratio] than human adenovirus type 12 (4).…”