Oncogenic Wnt3a is a promising sensitive biomarker for monitoring hepatocarcinogenesis

Yao, Min; Wang, Jianjun; Chen, Xiyu; Sai, Wen-Li; Yang, Jie; Wang, Defeng; Wang, Li; Yao, Dengfu

doi:10.1016/j.hbpd.2022.11.004

Search citation statements

Order By: Relevance

Paper Sections

Select...

Wnt3a Signalling2

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite1

Independent0

Authors

Journals

Cited by 1 publication

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Abnormal activation of Wnt3a in hepatocarcinogenesis[ 49 , 53 , 56 , 57 , 61 ]. The Wnt/β-catenin signalling pathway contains 19 mammalian Wnt proteins.…”

Section: Wnt3a Signallingmentioning

confidence: 99%

See 1 more Smart Citation

Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

Yao,

Fang,

Xie

et al. 2024

World J Gastrointest Oncol

Self Cite

View full text Add to dashboard Cite

The prevention and early diagnosis of liver cancer remains a global medical challenge. During the malignant transformation of hepatocytes, a variety of oncogenic cellular signalling molecules, such as novel high mobility group-Box 3, angiopoietin-2, Golgi protein 73, glypican-3, Wnt3a (a signalling molecule in the Wnt/β-catenin pathway), and secretory clusterin, can be expressed and secreted into the blood. These signalling molecules are derived from different signalling pathways and may not only participate in the malignant transformation of hepatocytes but also become early diagnostic indicators of hepatocarcinogenesis or specific targeted molecules for hepatocellular carcinoma therapy. This article reviews recent progress in the study of several signalling molecules as sensitive biomarkers for monitoring hepatocarcinogenesis.

show abstract

“… Abnormal activation of Wnt3a in hepatocarcinogenesis[ 49 , 53 , 56 , 57 , 61 ]. The Wnt/β-catenin signalling pathway contains 19 mammalian Wnt proteins.…”

Section: Wnt3a Signallingmentioning

confidence: 99%

“…A dynamic model of rat hepatocarcinogenesis was successfully established to investigate the alteration of Wnt3a and its monitoring value in early HCC[ 61 ]. Based on liver pathological examination with HE staining, the rats were divided into the NC, HD, PC and HCC groups.…”

Section: Wnt3a Signallingmentioning

confidence: 99%