1989
DOI: 10.1038/bjc.1989.378
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Oncogenic transformation of murine C3H 10T1/2 cells resulting from DNA double-strand breaks induced by a restriction endonuclease

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Cited by 35 publications
(13 citation statements)
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References 15 publications
(19 reference statements)
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“…Alteration of cell morphology and growth pattern in the M. fermentans-infected cultures was noted after passage 6. Similar changes were also found in M. penetrans-infected cultures, but only after passage [15][16]. In comparison, none of the mycoplasma-free control cultures passed in parallel showed morphological transformation.…”
Section: Resultssupporting
confidence: 57%
See 1 more Smart Citation
“…Alteration of cell morphology and growth pattern in the M. fermentans-infected cultures was noted after passage 6. Similar changes were also found in M. penetrans-infected cultures, but only after passage [15][16]. In comparison, none of the mycoplasma-free control cultures passed in parallel showed morphological transformation.…”
Section: Resultssupporting
confidence: 57%
“…Since the question of whether mycoplasmas can induce malignant transformation of mammalian cells may have great significance in general biology, tumor biology, as well as direct clinical implications, we have examined mycoplasmal transforming effects in the murine embryonic C3H/10T½/2 (C3H) cell system, pne of the few standard test systems available for studying potential carcinogenic agents or factors in animals or humans (12)(13)(14)(15). Using this model system with low inherent spontaneous transformation (12), we did not find mycoplasmas induced acute mammalian cell transformation described in the earlier studies.…”
mentioning
confidence: 99%
“…When genomic DNA strand breaks have been generated by the introduction of restriction endonucleases into cells, a strikingly increased frequency of chromosomal aberrations has been observed in cells reaching mitosis (6,7). In addition, restriction enzymeinduced strand breaks have been found to increase neoplastic transformation (5,8,68). Finally, unrepaired or irreparable DNA strand breaks may trigger cell death.…”
Section: Discussionmentioning
confidence: 99%
“…DNA double-strand breaks can cause chromosomal rearrangements (1), which can lead to cell killing (13), mutagenesis (25), and cell transformation (5). To understand how DNA double-strand breaks lead to genetic rearrangements, it is important to understand the mechanisms of DNA double-strand-break rejoining and how these processes are carried out at the DNA and chromosomal levels.…”
mentioning
confidence: 99%