Oncogenic Signaling in Gastric Carcinoma

Santos-Silva, Filipe

doi:10.5772/21729

Cited by 2 publications

(1 citation statement)

References 161 publications

(150 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several recent studies suggest that apoptosis and cell cycle arrest may have important roles in the therapeutic effects of continuous low-energy 125 I irradiation (14,15,18). In addition, the VEGF and NF-κB signaling pathway may be involved in the gastric cancer oncogenic signaling pathway (19). However, comprehensive knowledge on this topic, particularly at the molecular level, is still lacking.…”

Section: Discussionmentioning

confidence: 99%

Effect of brachytherapy on NF-κB and VEGF in gastric carcinoma xenografts

Zhang

Jin

et al. 2014

Oncology Reports

View full text Add to dashboard Cite

Iodine-125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. However, the radiobiological mechanism underlying brachytherapy remains unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on the cell cycle distribution, apoptosis, expression of NF-κB and VEGF and tumor growth in a human gastric cancer xenograft model. To create an animal model of gastric cancer, SGC-7901 cells were surgically implanted into mice. The 60 mice bearing SGC-7901 gastric cancer xenografts were randomly separated into 2 groups. Sham seeds (0 mCi) were implanted into the control group (n=30); 125I seeds (0.6 mCi) were implanted into the treatment group (n=30). At 28 days after irradiation, apoptosis was detected by flow cytometry. fluorescence micrograph detected intense VEGF and NF-κB immunofluorescence in the tumor samples, and changes in NF-κB and VEGF mRNA and protein expression were assessed by real-time PCR and western blot analysis, respectively. The tumor volume and weight were measured 0-28 days after 125I seed implantation. 125I seed irradiation induced significant apoptosis and G2/M phase arrest. Reduction in the intensities of VEGF and NF-κB immunofluorescence in tumor vessels was observed after treatment. NF-κB and VEGF mRNA and protein expression levels were substantially lower in the implantation treatment group than in the control group. Consequently, 125I seed implantation inhibited cancer growth and reduced cancer volume. The present study revealed that 125I seed irradiation significantly induced apoptosis and cell cycle arrest in the human gastric cancer xenografts. 125I-induced changes in NF-κB and VEGF expression are suggested as potential mechanisms underlying effective brachytherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of brachytherapy on NF-κB and VEGF in gastric carcinoma xenografts

Zhang

Jin

et al. 2014

Oncology Reports

View full text Add to dashboard Cite

show abstract

Gastric Cancer: Molecular Pathology State

Altieri¹,

Arcari²,

Rippa³

2013

Current Topics in Gastritis - 2012

View full text Add to dashboard Cite

Despite the progressive decrease observed in the past fifty years, gastric cancer GC is the fourth of the world rankings incidence of various types of cancer and is the second as a cause of cancer-related death. There is distinct geographical variation in gastric cancer incidence with the highest rates reported from Japan, Korea and Eastern Asia. Other high incidence areas are Eastern Europe and parts of Latin America, while Western Europe, Africa, Australia and the US generally have low incidence rates. In the last decade there has been a downward trend in the incidence and mortality from this cancer. The reasons are to be found in the improvement of food both as regards its preservation procedures and the variability in the diet and for the decrease of infection by Helicobacter pylori H. pylori . H. pylori infection is strongly associated with risk for stomach cancer. Likely, this association is supported by the strong link between this bacterium infections and precancerous lesions, including chronic atrophic gastritis and dysplasia. The development of gastric cancer is characterized by multistage process in which several alterations of genetic and epigenetic nature accumulate. These alterations are mainly related to abnormalities of growth factors and receptors, DNA mismatch repair genes, angiogenic factors, transcription factors, adaptor proteins, cell cycle regulators, and many other macromolecular cell components. All these abnormalities identify from one side the molecular and biological aspect of gastric cancer cells and from the other might suggest possible strategies for therapeutic intervention.The most important epigenetic alterations are confined within the chromatin structure like chromatin remodeling, DNA methylation and histone modification. These molecular alterations are generally common in gastric cancer, independently from its classification gastric or intestinal . Also genetic polymorphism represents a possible endogenous cause of cancer risk. However, it must be considered that genetic polymorphisms might influence the efficacy of gastric cancer therapy and the toxicity of anticancer drugs. Although the worldwide decline in incidence and recent diagnostic and therapeutic advances provided excellent survival for

show abstract

Oncogenic Signaling in Gastric Carcinoma

Cited by 2 publications

References 161 publications

Effect of brachytherapy on NF-κB and VEGF in gastric carcinoma xenografts

Effect of brachytherapy on NF-κB and VEGF in gastric carcinoma xenografts

Gastric Cancer: Molecular Pathology State

Contact Info

Product

Resources

About