Oncogenic <scp>LINC00857</scp> recruits <scp>TFAP2C</scp> to elevate <scp>FAT1</scp> expression in gastric cancer

Zhang, Wenqin; Ji, Kaiyue; Min, Congcong; Zhang, Cuiping; Yang, Lin; Zhang, Qi; Tian, Zibin; Zhang, Mengyuan; Wang, Xinyu; Li, Xiaoyu

doi:10.1111/cas.15394

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…4A ). It is worth noting that, among them, linc00857 has been shown to be an oncogenic lncRNA in various cancers [ 16 , 17 ], while GPX4 is one of the essential enzymes involved in ferroptosis. We therefore focused on these two FOXP3 downstream members.…”

Section: Resultsmentioning

confidence: 99%

FOXP3 promote the progression of glioblastoma via inhibiting ferroptosis mediated by linc00857/miR-1290/GPX4 axis

Cao,

He,

Lan

et al. 2024

Cell Death Dis

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The oncogenic properties of members belonging to the forkhead box (FOX) family have been extensively documented in different types of cancers. In this study, our objective was to investigate the impact of FOXP3 on glioblastoma multiforme (GBM) cells. By conducting a screen using a small hairpin RNA (shRNA) library, we discovered a significant association between FOXP3 and ferroptosis in GBM cells. Furthermore, we observed elevated levels of FOXP3 in both GBM tissues and cell lines, which correlated with a poorer prognosis. FOXP3 was found to promote the proliferation of GBM cells by inhibiting cell ferroptosis in vitro and in vivo. Mechanistically, FOXP3 not only directly upregulated the transcription of GPX4, but also attenuated the degradation of GPX4 mRNA through the linc00857/miR-1290 axis, thereby suppressing ferroptosis and promoting proliferation. Additionally, the FOXP3 inhibitor epirubicin exhibited the ability to impede proliferation and induce ferroptosis in GBM cells both in vitro and in vivo. In summary, our study provided evidences that FOXP3 facilitates the progression of glioblastoma by inhibiting ferroptosis via the linc00857/miR-1290/GPX4 axis, highlighting FOXP3 as a potential therapeutic target for GBM.

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Section: Resultsmentioning

confidence: 99%

FOXP3 promote the progression of glioblastoma via inhibiting ferroptosis mediated by linc00857/miR-1290/GPX4 axis

Cao,

He,

Lan

et al. 2024

Cell Death Dis

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“…FAT1, a sizable transmembrane protein, plays a significant role in diverse biological processes, encompassing cell adhesion, migration, and proliferation (28,29). Extensive research has unveiled frequent upregulation of FAT1 in numerous cancer types, including lung cancer, suggesting its potential as a pivotal contributor to tumorigenesis (30,31). Consequently, FAT1 emerges as a promising candidate for both therapeutic intervention and prognostic assessment in cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Pan-cancer analysis predict that FAT1 is a therapeutic target and immunotherapy biomarker for multiple cancer types including non-small cell lung cancer

Ding,

Huang,

et al. 2024

Front. Immunol.

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FAT1, a substantial transmembrane protein, plays a pivotal role in cellular adhesion and cell signaling. Numerous studies have documented frequent alterations in FAT1 across various cancer types, with its aberrant expression being linked to unfavorable survival rates and tumor progression. In the present investigation, we employed bioinformatic analyses, as well as in vitro and in vivo experiments to elucidate the functional significance of FAT1 in pan-cancer, with a primary focus on lung cancer. Our findings unveiled FAT1 overexpression in diverse cancer types, including lung cancer, concomitant with its association with an unfavorable prognosis. Furthermore, FAT1 is intricately involved in immune-related pathways and demonstrates a strong correlation with the expression of immune checkpoint genes. The suppression of FAT1 in lung cancer cells results in reduced cell proliferation, migration, and invasion. These collective findings suggest that FAT1 has potential utility both as a biomarker and as a therapeutic target for lung cancer.

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“…TFAP2C collaborating with LINC00857, boosts FAT atypical cadherin 1 (FAT1) expression (highly expressed in gastric cancer)to drive tumorigenesis and EMT [ 42 ].…”

Section: The Functions Of Tfap2 In Different Aspects Of Tumor Biologymentioning

confidence: 99%

Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

et al. 2023

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The transcription factor family activator protein 2 (TFAP2) is vital for regulating both embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E. The importance of TFAP2 in tumor biology is becoming more widely recognized. While TFAP2D is not well studied, here, we mainly focus on the other four TFAP2 members. As a transcription factor, TFAP2 regulates the downstream targets directly by binding to their regulatory region. In addition, the regulation of downstream targets by epigenetic modification, posttranslational regulation, and interaction with noncoding RNA have also been identified. According to the pathways in which the downstream targets are involved in, the regulatory effects of TFAP2 on tumorigenesis are generally summarized as follows: stemness and EMT, interaction between TFAP2 and tumor microenvironment, cell cycle and DNA damage repair, ER- and ERBB2-related signaling pathway, ferroptosis and therapeutic response. Moreover, the factors that affect TFAP2 expression in oncogenesis are also summarized. Here, we review and discuss the most recent studies on TFAP2 and its effects on carcinogenesis and regulatory mechanisms.

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Oncogenic LINC00857 recruits TFAP2C to elevate FAT1 expression in gastric cancer

Cited by 7 publications

References 24 publications

FOXP3 promote the progression of glioblastoma via inhibiting ferroptosis mediated by linc00857/miR-1290/GPX4 axis

FOXP3 promote the progression of glioblastoma via inhibiting ferroptosis mediated by linc00857/miR-1290/GPX4 axis

Pan-cancer analysis predict that FAT1 is a therapeutic target and immunotherapy biomarker for multiple cancer types including non-small cell lung cancer

Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

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