Oncogenic Potential and Clinical Implications of Giant Endometrial Polyps: A Case Report and Literature Review

Staalduinen, Brittany van; Stahler, Andrew; Abied, Catherine; Shats, Rita; Lakhi, Nisha

doi:10.1155/2018/8753463

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…Giant endometrial polyps, as seen in the present case study, are exceedingly rare variants of classical polyps. According to the pertinent world literature, there are <15 cases of giant endometrial polyps which have been reported so far[56891011121920212223] and a very small number have been documented from India. [2021] On reviewing the handful of cases mentioned till date, various clinicopathological features of this rare entity draws the attention.…”

Section: Discussionmentioning

confidence: 99%

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Giant endometrial polyp: An enigma in a postmenopausal woman

Sharma

2018

J Mid-life Health

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Giant polyp is an unusual female genital tract pathology, commonly arising from the cervix than the endometrium. It is a great masquerader of cervical or endometrial malignancy and can lead to a diagnostic dilemma and unnecessary aggressive interventions. Experience in one such case of an extremely rare protruding giant endometrial polyp in a 58-year-old postmenopausal female is being described herewith so as to create awareness among the dealing clinicians. The approach to such a case, differential diagnosis, and review of the literature is also presented.

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Section: Discussionmentioning

confidence: 99%

“…The most common presenting symptom is vaginal bleeding and only a few of them presented with an introital mass. [569212223] The polyp size varied from 4.5–12 cm in its greatest dimension. Maximum of the cases developed with the use of selective estrogen receptor modulators such as tamoxifen or raloxifene or a phytoestrogen (thyme).…”

Section: Discussionmentioning

confidence: 99%

Giant endometrial polyp: An enigma in a postmenopausal woman

Sharma

2018

J Mid-life Health

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Advanced uterine adenosarcoma with sarcomatous overgrowth in a young woman

et al. 2019

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Rationale: Uterine adenosarcoma (UA) with sarcomatous overgrowth (ASSO) is a rare and aggressive disease. Herein, wereported the case of a young patient with advanced uterine ASSO. Patients concerns: A 29-year-old woman with the diagnoses of endometrial polyp and adenomyosis underwent hysteroscopic endometrial polypectomy for the giant endometrial polyp. Postoperative regular ultrasound scan indicated thickened endometriumand an ill-defined mass with continuous enlargement in the myometrium of the posterior wall of the uterus, which was considered as an adenomyoma. Two years after hysteroscopy, she was re-admitted due to lower abdominal distension and large pelvic mass. At that time, she had taken oral short-acting contraceptives for 2.5 years. Diagnoses: Magnetic resonance imaging (MRI) of the pelvis revealed an irregular mass with the size of 12∗56∗107 mm3 in the right annex area, without distinct border with the rectum, moreover, an uneven intrauterine echo that has no obvious boundary with uterine wall. Right ovarian cancer and adenomyoma were initially considered. Interventions: The patient received transperitoneal retroperitoneal pelvic combined with total viscera resection, including uterus, bilateral appendages and rectum, omentectomy, appendectomy, lymphadenectomy, and ileostomy. Postoperative pathology confirmed ASSO in the uterine cavity and muscular layer, the whole cervical duct and the right adnexal. She underwent 2 systemic chemotherapy sessions after the surgery. The chemotherapy regimen was ifosfamide 2.5 g day 1 to 3, with liposomal doxorubicin 40 mg day 1. Outcomes: The final diagnosis was uterine ASSO, International Federation of Gynecology and Obstetrics stage IVa. The patient has been following-up so far, with no progression. Lessons: Review of the case indicated that history of long-term oral short-acting contraceptives and giant endometrial polyps may be the high-risk factors for UA. For patients with high-risk factors, the follow-up ultrasound scan should be more frequently conducted. Moreover, 3D-ultrasound, MRI and outpatient hysteroscopy are recommended for routine screening. Placement of levonorgestrel-releasing intra-uterine system after hysteroscopy may be an effective intervention for patients with a high risk of giant polyps. Cluster of Differentiation 10, Estrogen receptor, Progesterone receptor, and nuclear antigen may be predictors for prognosis and selection of individualized treatment program.

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Fifteen‐Centimeter Giant Tamoxifen‐Associated Endometrial Polyp Presenting With Constipation: A Case Report and Review of the Literature

Apornvirat,

Suwannarurk

2024

Case Reports in Obstetrics and Gynecology

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Endometrial polyps are benign disorganized growth of endometrial glands and stroma in the uterine cavity. They are associated with subfertility, abnormal uterine bleeding, and tamoxifen use. While most polyps are smaller than 2 cm in size, rare giant polyps can cause concerns over malignancy. We report a case of a 15 cm giant endometrial polyp in a 58‐year‐old woman with a history of tamoxifen use who presented with an uncommon complaint of constipation. Additionally, a literature review of giant endometrial polyp cases is presented. This case represents the largest reported endometrial polyp to date.

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Oncogenic Potential and Clinical Implications of Giant Endometrial Polyps: A Case Report and Literature Review

Cited by 5 publications

References 12 publications

Giant endometrial polyp: An enigma in a postmenopausal woman

Giant endometrial polyp: An enigma in a postmenopausal woman

Advanced uterine adenosarcoma with sarcomatous overgrowth in a young woman

Fifteen‐Centimeter Giant Tamoxifen‐Associated Endometrial Polyp Presenting With Constipation: A Case Report and Review of the Literature

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