Oncogenic Pathways Provide Clue to the Etiology of Human Mesial Temporal Lobe Epilepsy

Goldman, Alica M.

doi:10.1001/jamaneurol.2023.0465

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…It is estimated that there are about 70 million epilepsy patients worldwide, and the prevalence rate in China is 4.6‰~7.0‰, with an annual growth of (28.8~35.0)/100,000 (2,3). The etiology of epilepsy has been reported to be related to cortical developmental disorders, central nervous system infections, tumors, trauma, cerebrovascular diseases, neurodegeneration, and genetic metabolic diseases (1,(4)(5)(6)(7). Several brain regions are involved in seizures including, thalamus, hippocampus, amygdala, insula, and anterior cingulate gyrus.…”

Section: Introductionmentioning

confidence: 99%

Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis

Ma,

Cheng,

Hou

et al. 2024

Front. Neurol.

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ObjectiveTo investigate the serum biomarkers in patients with drug-resistant epilepsy (DRE).MethodsA total of 9 DRE patients and 9 controls were enrolled. Serum from DRE patients was prospectively collected and analyzed for potential serum biomarkers using TMT18-labeled proteomics. After fine quality control, bioinformatics analysis was conducted to find differentially expressed proteins. Pathway enrichment analysis identified some biological features shared by differential proteins. Protein–protein interaction (PPI) network analysis was further performed to discover the core proteins.ResultsA total of 117 serum differential proteins were found in our study, of which 44 were revised upwards and 73 downwards. The up-regulated proteins mainly include UGGT2, PDIA4, SEMG1, KIAA1191, CCT7 etc. and the down-regulated proteins mainly include ROR1, NIF3L1, ITIH4, CFP, COL11A2 etc. Pathway enrichment analysis identified that the upregulated proteins were mainly enriched in processes such as immune response, extracellular exosome, serine-type endopeptidase activity and complement and coagulation cascades, and the down-regulated proteins were enriched in signal transduction, extracellular exosome, zinc/calcium ion binding and metabolic pathways. PPI network analysis revealed that the core proteins nodes include PRDX6, CAT, PRDX2, SOD1, PARK7, GSR, TXN, ANXA1, HINT1, and S100A8 etc.ConclusionThe discovery of these differential proteins enriched our understanding of serum biomarkers in patients with DRE and potentially provides guidance for future targeted therapy.

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