Oncogenic osteomalacia — Hypophosphataemic spectrum from “benignancy” to “malignancy”

Chiam, Priscilla Pei Sze; Tan, Hong Chang; Bee, Yong Mong; Chandran, Manju

doi:10.1016/j.bone.2012.11.040

Cited by 26 publications

(9 citation statements)

References 40 publications

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“…An increased secretion of fibroblast growth factor-23 (FGF-23) is considered the pathological factor responsible for the disease (2,3). The awareness of the disease has recently increased (4), even though no more than 300 cases have been described so far (5,6).…”

Section: Introductionmentioning

confidence: 99%

Six-year follow-up of a characteristic osteolytic lesion in a patient with tumor-induced osteomalacia

Piemonte

Romagnoli

Cipriani

et al. 2014

European Journal of Endocrinology

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Objective: Tumor-induced osteomalacia is a rare paraneoplastic syndrome characterized by hypophosphatemia and inappropriately normal or low 1,25-dihydroxyvitamin D. Clinical case: Here, we report a 6-year postoperative follow-up of a patient with oncogenic osteomalacia with a distinctive skeletal manifestation. The latter was characterized by an almost linear lytic lesion of a few millimeters with irregular borders, mainly involving the trabecular compartment but extending into cortical shell, located in the middle third of the right fibula. Six years after tumor resection, a sclerotic repair with a complete recovery was observed. Furthermore, we monitored a striking increase in bone mineral density throughout the observation period, reaching a peak of 73% over basal values at lumbar spine after 2 years; at total femur and radius, the peak was 47.5 and 4.6% respectively, after 4 years from tumor resection. Conclusions: We report for the first time that an osteolytic lesion may be part of the skeletal involvement in tumor-induced osteomalacia.

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Section: Introductionmentioning

confidence: 99%

Six-year follow-up of a characteristic osteolytic lesion in a patient with tumor-induced osteomalacia

Piemonte

Romagnoli

Cipriani

et al. 2014

European Journal of Endocrinology

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“…It is important to differentiate our case of malignant presentation PMC 13 – 15 since histologically fusiform cells present invasion, which differentiate them from mesenchymal tumours. In this case, unlike the previous reported osteosarcoma, we had levels of FGF-23 that decreased after surgery, however, they will not be normalised until after treatment with chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Tumour-induced Osteomalacia Secondary to a Sarcoma

Rodríguez-Velver

Zapata-Rivera

Montes-Villarreal

et al. 2016

European Endocrinology

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“…Pathologically, four morphologic patterns of PMTs have been described and widely accepted: primitive-appearing mixed connective tissue, osteoblastoma-like, nonossifying fibroma-like, and ossifying fibroma-like ( 10 , 11 , 17 , 36 , 37 ). It is now believed that the latter three variants may reflect different bone-specific reaction patterns considered within the spectrum of PMT-MCTs ( 38 – 40 ).…”

Section: Discussionmentioning

confidence: 99%

CT and MR imaging features in phosphaturic mesenchymal tumor-mixed connective tissue: A case report

Shi

Deng²,

et al. 2018

Oncol Lett

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Phosphaturic mesenchymal tumor-mixed connective tissue (PMT-MCT) is rare and usually benign and slow-growing. The majority of these tumors is associated with sporadic tumor-induced osteomalacia (TIO) or rickets, affect middle-aged individuals and are located in the extremities. Previous imaging studies often focused on seeking the causative tumors of TIO, not on the radiological features of these tumors, especially magnetic resonance imaging (MRI) features. PMT-MCT remains a largely misdiagnosed, ignored or unknown entity by most radiologists and clinicians. In the present case report, a review of the known literature of PMT-MCT was conducted and the CT and MRI findings from three patient cases were described for diagnosing the small subcutaneous tumor. Typical MRI appearances of PMT-MCT were isointense relative to the muscles on T1-weighted imaging, and markedly hyperintense on T2-weighted imaging containing variably flow voids, with markedly heterogeneous/homogenous enhancement on post contrast T1-weighted fat-suppression imaging. Short time inversion recovery was demonstrated to be the optimal sequence in localizing the tumor.

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Oncogenic osteomalacia — Hypophosphataemic spectrum from “benignancy” to “malignancy”

Cited by 26 publications

References 40 publications

Six-year follow-up of a characteristic osteolytic lesion in a patient with tumor-induced osteomalacia

Six-year follow-up of a characteristic osteolytic lesion in a patient with tumor-induced osteomalacia

Tumour-induced Osteomalacia Secondary to a Sarcoma

CT and MR imaging features in phosphaturic mesenchymal tumor-mixed connective tissue: A case report

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