Oncogenic human papillomavirus is not helpful for cytology screening of the precursor lesions of anal cancers in Taiwanese men who are infected with human immunodeficiency virus

Cheng, Shu Hsing; Wang, Chi Chao; Chang, Shih Lung; Chu, Fang; Hsueh, Yu Mei

doi:10.1007/s10147-015-0804-9

Cited by 19 publications

(16 citation statements)

References 41 publications

(62 reference statements)

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“…In total, 9 studies reported on the performance of any HR‐HPV test for detecting anal precancers and cancers, including 671 findings of AIN2 or greater and 2154 findings of AIN2 or lower . Overall, the pooled sensitivity and specificity of HR‐HPV for detecting AIN2 or greater was 91.3% (95% CI, 78.9%‐96.7%) and 33.1% (95% CI, 22.2%‐46.3%), respectively (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Genotyping for HPV16/HPV18 has the potential to improve the specificity of HPV testing for anal precancer detection. In total, 5 studies reported on the performance of HPV16/HPV18 genotyping for the detection of anal precancers and cancers, including 510 findings of AIN2 or greater and 1562 findings of AIN2 or less . Overall, the pooled sensitivity and specificity of HPV16/HPV18 for detecting AIN2 or greater was 39.9% (95% CI, 22.4%‐60.5%) and 74.3% (95% CI, 67.3%‐80.1%), respectively.…”

Section: Resultsmentioning

confidence: 99%

“…In total, 5 studies reported on the performance of HPV16/HPV18 genotyping for the detection of anal precancers and cancers, including 510 findings of AIN2 or greater and 1562 findings of AIN2 or less. 67,71,72,82,83 Overall, the pooled sensitivity and specificity of HPV16/ HPV18 for detecting AIN2 or greater was 39.9% (95% CI, 22.4%-60.5%) and 74.3% (95% CI, 67.3%-80.1%), respectively. Among the 4 studies that were restricted to HIV-positive MSM, the pooled sensitivity and specificity was 41.3% (95% CI, 22.2%-63.3%) and 68.5% (95% CI, 63.5%-73.0%), respectively.…”

Section: Performance Of Hpv Testing For the Detection Of Anal Precancersmentioning

confidence: 98%

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Strategies for screening and early detection of anal cancers: A narrative and systematic review and meta‐analysis of cytology, HPV testing, and other biomarkers

Clarke

Wentzensen

2018

Cancer Cytopathology

110

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Anal cancer incidence and mortality have been increasing over the past decade. Although the incidence in the general population remains low, it is much higher in certain subgroups, including those living with human immunodeficiency virus and men who have sex with men. Approximately 90% of anal squamous cell cancers are caused by infection with carcinogenic human papillomavirus (HPV). Given the common etiology between anal and cervical carcinogenesis, screening for anal cancer has been proposed in certain high-risk populations using strategies adapted from cervical cancer prevention. In this review, the authors discuss important differences in anal and cervical cancer regarding the populations at risk, disease natural history, and clinical procedures and outcomes that need to be considered when evaluating strategies for anal cancer screening. They also performed a systematic review and meta-analysis of the performance of anal cytology, anal HPV testing, and various biomarkers for the detection of anal precancers and cancers. The implications of these performance estimates are summarized in the context of risk-based screening and management of anal precancers, and important research gaps are highlighted that need to be addressed to fully understand the benefits and harms of anal cancer screening. Cancer Cytopathol 2018. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Performance Of Hpv Testing For the Detection Of Anal Precancersmentioning

confidence: 98%

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Strategies for screening and early detection of anal cancers: A narrative and systematic review and meta‐analysis of cytology, HPV testing, and other biomarkers

Clarke

Wentzensen

2018

Cancer Cytopathology

110

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“…Previous studies in Taiwan showed that genital HPV was detected in 45.3% of 305 HIV-infected men 13 and that 90% of 196 HIV-infected men had anal HPV, 81% of whom had oncogenic anal HPVs. 14 In another study, the authors demonstrated that 77% of 130 HIV-infected homosexual men had anal HPV infection. 15 In Japan, 75% of HIV-infected MSM were shown to harbour anal oncogenic HPVs.…”

Section: Introductionmentioning

confidence: 98%

Multiple types of human papillomavirus infection and anal precancerous lesions in HIV-infected men in Taiwan: a cross-sectional study

et al. 2018

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ObjectivesThis study aimed to assess the relationship between infection with multiple human papillomavirus (HPV) types and abnormal anal cytology in HIV-infected men.DesignAn observational, cross-sectional study.SettingA regional referral hospital in Taiwan.ParticipantsIn total, 714 HIV-infected men were enrolled between March 2011 and June 2016. Thin preparation anal Pap smears were interpreted according to the 2001 Bethesda System. Thirty-seven types of HPV were detected by reverse line blotting, including 13 oncogenic types and 24 non-oncogenic types.Outcome measuresThe relationship between anal HPV infection and abnormal anal cytology in people of Asian ethnicity and the coverage efficacy in HPV-vaccinated HIV-infected men.ResultsOn anal cytology, 175 (24.5%) subjects had atypical squamous cells of undetermined significance (ASCUS) or higher grades of dysplasia, including 87 (49.7%) with ASCUS, 73 (41.7%) with low-grade squamous intraepithelial lesions (LSILs) and 15 (8.6%) with high-grade squamous intraepithelial lesions (HSILs). A higher proportion of subjects with those without LSIL/HSIL (93.1% vs 67.3%, P<0.0001) had multiple HPV types. The odds of having LSIL/HSIL increased with an increasing number of HPV types: the ORs ranged from 1 for no HPV types to 6.96 (95% CI 2.38 to 20.37) for more than five types (Ptrend <0.0001). Multivariate logistic regression analysis showed a significant association between LSIL/HSIL and the number of HPV genotypes present (OR 1.20; 95% CI 1.02 to 1.42, P<0.05). HPV types covered by the nonavalent HPV vaccine (types 6/11/16/18/31/33/45/52/58) were detected in 70.1% of the patients in this study.ConclusionsThe odds of having anal LSIL/HSIL are approximately seventimes greater in HIV-infected men with than withoutsix or more types of HPV. Multiple HPV types in HIV-infected patients deserves aggressive follow-up, and HPV vaccination programme require scaling up.

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“…Previous studies in western countries have shown that the rate of anal HPV infection in men who had HIV is in the range of 46-92% [11,13,14]. A study conducted in southern Taiwan showed that 77% of 130 MEM were infected with HIV and had anal HPV infections [15], whereas in northern Taiwan, 90.8% of men who had HIV had also tested positive for anal HPV [16].…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection

Wang

Chang

Chu

et al. 2019

J Infect Dev Ctries

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Introduction: Anal cancer screening has not been adopted by Taiwanese care providers. The study aim was to explore the differences of anal cytology and HPV detection among men with and without HIV. Methodology: In this case-control study, men with HIV who attended one of the outpatient clinics of Taoyuan General Hospital were enrolled as cases. Men who had experienced condomless sex and tested HIV negative were enrolled as controls. Anal swabs were collected for thin-preparation anal cytology and HPV genotyping. Results: A total of 288 men who had tested positive for HIV and 208 who had tested HIV negative were enrolled; 75% of subjects with HIV and 30.3% of those without HIV had tested positive for various types of HPV (P < 0.001). Anal cell dysplasia, including atypical squamous cells with undetermined significance (ASCUS), low-grade squamous intraepithelial lesions (LSILs), high-grade squamous intraepithelial lesions (HSILs), or atypical squamous cells cannot exclude HSIL (ASC-H), were noted in 20.8% of men with HIV and 4.8% of those without HIV (P < 0.001). In multivariate analysis, HIV serostatus, history of sexually transmitted infections, having male sexual partners, and practice of anal sex were correlated significantly with detection of any type of HPV. Additionally, both oncogenic and non-oncogenic HPV types were significantly associated with anal cytology dysplasia. Conclusions: We strongly suggest that there should be awareness of anal HPV infection and related anal cellular dysplasia in at-risk populations.

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Oncogenic human papillomavirus is not helpful for cytology screening of the precursor lesions of anal cancers in Taiwanese men who are infected with human immunodeficiency virus

Abstract: Anal cytology yielding atypical squamous cells of undetermined significance or higher grades could detect two-thirds of high-grade anal intraepithelial neoplasias in HIV-infected men and should be promoted for anal cancer prevention.

Cited by 19 publications

References 41 publications

Strategies for screening and early detection of anal cancers: A narrative and systematic review and meta‐analysis of cytology, HPV testing, and other biomarkers

Strategies for screening and early detection of anal cancers: A narrative and systematic review and meta‐analysis of cytology, HPV testing, and other biomarkers

Multiple types of human papillomavirus infection and anal precancerous lesions in HIV-infected men in Taiwan: a cross-sectional study

Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection

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