Oncogenic human papilloma virus and cervical pre-cancerous lesions in brothel-based sex workers in India

Sarkar, Kamalesh; Bhattacharya, Swati; Bhattacharyya, Souvik; Chatterjee, S.; Mallick, Aiyel Haque; Chakraborti, Sekhar; Chatterjee, Debashree; Bal, Baishali

doi:10.1016/j.jiph.2008.09.001

Cited by 15 publications

(11 citation statements)

References 17 publications

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“…Even in studies among sex workers, a population which is highly exposed to HPV, Kjaer et al and Sarkar et al observed a considerably decreasing trend in HPV prevalence with age in spite of continuous high levels of sexual activity. [17,18] This is probably due to development of acquired immunity to HPV infection following repeated exposure. But, in this study, it was found that the prevalence of HPV 16/18 to be almost constant across different age groups among the controls.…”

Section: Discussionmentioning

confidence: 99%

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Oncogenic HPV among HIV infected female population in West Bengal, India

et al. 2011

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BackgroundPrevalence of both cervical cancer and Human Immunodeficiency Virus (HIV) infection are very high in India. Natural history of Human Papilloma Virus (HPV) infection is known to be altered in HIV positive women and there is an increased possibility of persistence of HPV infections in this population. Therefore, this study was conducted to understand the epidemiology and circulating genotypes of oncogenic HPV among HIV positive and negative female population in West Bengal, India.MethodsIn this hospital-based cross-sectional study, 93 known HIV positive females attending a pre-ART registration clinic and 1106 HIV negative females attending a Reproductive and Child Health Care Clinic were subjected to study. Cervical cell samples collected from the study population were tested for the presence of HPV 16, 18 using specific primers. Roche PCR assay was used to detect other specific HPV genotypes in the cervical cells specimens of HIV positive cases only.ResultsPrevalence of HPV 16, 18 among HIV positive females (32.2%; n = 30) was higher than HIV negative females (9.1%; n = 101). About 53% (23/43) of cases with oncogenic HPV were infected with genotypes other than 16, 18 either as single/multiple infections. HPV 18 and HPV 16 were the predominant genotypes among HIV positive and HIV negative subjects respectively. Oncogenic HPV was not found to be associated with age and duration of sexual exposure. But the presence of HIV was found to a statistically significant predictor oncogenic HPV.ConclusionThe currently available HPV vaccines offer protection only against HPV 16 and 18 and some cross- protection to few associated genotypes. These vaccines are therefore less likely to offer protection against cervical cancer in HIV positive women a high percentage of who were infected with non-16 and non-18 oncogenic HPV genotypes. Additionally, there is a lack of sufficient evidence of immunogenicity in HIV infected individuals. Therefore, prevention of cervical cancer in HIV positive women must be focused towards early detection of oncogenic HPV & cervical cytological abnormality followed by an appropriate treatment.

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Section: Discussionmentioning

confidence: 99%

“…On the other hand, frequent re- infection/reactivation due to multiple sex-partners, increased frequency of sex etc. might have helped in the development of immunity against HPV among sex workers in the study by Sarkar et al [18] which included young unmarried women. An in-depth cohort study from this region is required to understand this.…”

Section: Discussionmentioning

confidence: 99%

Oncogenic HPV among HIV infected female population in West Bengal, India

et al. 2011

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“…Also, both male and female sex workers may be at high risk of HPV infection due to multiple sexual partners and unprotected sexual activities, which can lead to the HPV transmission from person to person. (5)…”

Section: Introductionmentioning

confidence: 99%

Molecular Genotyping of Human Papillomavirus L1 Gene in Low-Risk and High-Risk Populations in Bangkok

Leaungwutiwong

Bamrungsak

Jittmittraphap

et al. 2015

Sexually Transmitted Diseases

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Background Human papillomavirus (HPV) infections in Thailand are a public health concern but information on HPV infection in sex workers and men who have sex with men (MSM) is limited. The aim of this study was to measure the prevalence and genotype distribution of HPV among low- and high-risk, HIV-negative populations. Methods A total of 300 participants were categorized as general women, female sex workers, MSM, and MSM sex workers. HPV infections were identified by the Papanicolaou (Pap) test and nested-PCR. A phylogenetic analysis of partial HPV L1 genes was performed. Results Abnormal cytology was found in 5% of general women, 10% of female sex workers, 24% of MSM and 28% of MSM sex workers. HPV was detected in 9% of general women, 13% of female sex workers and 30% in both MSM and the MSM sex workers. The prevalence of HPV high-risk genotypes was significantly higher in female sex workers and MSM while low-risk genotypes and genital warts were significantly higher in MSM sex workers. Significantly more patients with genital warts and CIN I/AIN I harbored low-risk genotypes while those with CIN II/AIN II harbored high-risk genotypes. Conclusion High- and low-risk HPV genotypes persist in high-risk groups in Bangkok. Some genotypes infecting at-risk populations are not vaccine-preventable. These findings may help to elucidate the prevalence of HPV infections in Thailand and serve as the basis for additional investigations into risk factors for these populations.

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“…Jia [37] 2015 China 309 Gomih-Alakija [38] 2014 Kenya 349 Aho [39] 2014 Guinea 223 Wang [40] 2013 China 288 Patel [41] 2013 Kenya 296 Marek [42] 2013 Hungary 34 Hoang [43] 2013 Vietnam 281 Ersan [11] 2013 Turkey 239 Yin [44] 2013 China 802 Keten [45] 2013 Turkey 137 Li [46] 2012 China 810 Huq [47] 2012 Bangladesh 809 Ghosh [48] 2012 India 45 Couture [49] 2012 Cambodia 220 Brown [50] 2012 Peru 199 Shikova [51] 2011 Bulgaria 106 Montano [52] 2011 Peru 87 Matsushita [53] 2011 Japan 196 Dal Pogetto [54] 2011 Brazil 102 Znazen [55] 2010 Tunisia 188 Smith [56] 2010 Madagascar 90 Luchters [57] 2010 Kenya 776 Rhee [58] 2010 South Korea 2308 Valle`s [59] 2009 Guatemala 297 Miyashita [60] 2009 Philippines 369 del Amo [61] 2009 Spain 549 Sultana [62] 2008 Bangladesh 293 Sarkar [63] 2008 India 229 Hernandez [64] 2008 Vietnam 282 Yun [65] 2008 South Korea 188 Gazi [66] 2008 Turkey 124 Didelot-Rousseau [67] 2006 Burkina Faso 360…”

Section: Study Characteristicsmentioning

confidence: 99%

Prevalence and Genotype Distribution of Genital Human Papillomavirus Infection in Female Sex Workers in the World: A Systematic Review and Meta-Analysis

Farahmand

Moghoofei

Monavari

et al. 2020

Preprint

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Background: Female sex workers (FSWs) are amongst the most susceptible groups to acquire human papillomavirus (HPV) infection and consequently, to develop cervical intraepithelial neoplasia and cervical cancer. This is the first systematic review and meta-analysis to provide estimates of the pooled prevalence of HPV infection and distribution of HPV types among FSWs across the world. Methods: Five computerized databases were searched for relevant studies published since the inception date of databases to September 2019. The pooled HPV prevalence was calculated by the random effect model described by DerSimonian-Laird. Subgroup analysis was performed to identify the probable sources of heterogeneity. The meta-analysis was performed using the “Metaprop” function in the R package Meta. Results: Sixty-six studies involving 22938 FSWs from 34 countries were included in this meta-analysis, and the pooled HPV prevalence was 41.97% (95% confidence interval (CI): 37.99%-46.05%). HPV-16 (10.42%, 95% CI: 8.61%–12.55%), HPV-52 (7.76%, 95% CI: 5.75%–10.39%), and HPV-53 (6.09%, 95% CI: 4.55%–8.12%) were the most common high-risk HPV types identified among FSWs. The polled estimated prevalence of HPV infection among FSWs before and after 2010 were slightly different, 43.64% (95% CI: 36.12%-51.46%) and 41.01% (95% CI: 36.35%-45.83%), respectively. Conclusion: Due to the high prevalence of HPV infection, particularly with high-risk types, FSWs have a great susceptibility to the development of cervical and vaginal cancers. Furthermore, they can transmit their infection to their clients, which may result in a high prevalence of HPV and incidence of HPV-associated malignancies among the general population.

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Oncogenic human papilloma virus and cervical pre-cancerous lesions in brothel-based sex workers in India

Cited by 15 publications

References 17 publications

Oncogenic HPV among HIV infected female population in West Bengal, India

Oncogenic HPV among HIV infected female population in West Bengal, India

Molecular Genotyping of Human Papillomavirus L1 Gene in Low-Risk and High-Risk Populations in Bangkok

Prevalence and Genotype Distribution of Genital Human Papillomavirus Infection in Female Sex Workers in the World: A Systematic Review and Meta-Analysis

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