Oncogenic DNA viruses

Hausen, Harald zur

doi:10.1038/sj.onc.1204958

Cited by 111 publications

(80 citation statements)

References 36 publications

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“…HPV types 16,18,31,33,35,39,45,51,52,56,58,59,68,73 and 82 are considered as high risk types while 6,11,40,42,43,44,54,61,70,72,81 and CP6 108 as low risk types (Munoz et al, 2003). Among high risk HPV types, HPV 16 and 18 are considered to be carcinogenic agents and are strongly implicated with the development of cervical cancer (IARC Monographs Working Group, 1995;zur Hausen, 2001).…”

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confidence: 99%

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

et al. 2006

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Telomerase is a ribonucleoprotein comprising an RNA template, the telomerase-associated protein and its catalytic subunit, human telomerase reverse transcriptase (hTERT). Telomerase activation is a critical step in cellular immortalisation and development of cancer. Enhanced telomerase activity has been demonstrated in cervical cancer. In the present study telomerase activity and hTERT mRNA expression were evaluated and correlated with the presence of human papillomavirus (HPV) infection and cytological changes in the cervical lesions. Telomerase activity was assayed by telomeric repeat amplification protocol, hTERT mRNA expression by reverse transcriptase polymerase chain reaction and presence of high risk HPV (HR-HPV) infection by polymerase chain reaction. Out of 154 cervical samples of different cytology, 90 (58.44%) were positive for HR-HPV types 16/18, while among 55 normal cervical scrapes, 10 (18.18%) were HPV DNA positive. All 59 invasive cancer samples showed a very high telomerase activity. Among dysplasia, seven (63.6%) mild dysplasia, 18 (100%) of moderate, 20 (100%) of severe dysplasia and 6 (100%) carcinoma in situ (CIS) samples were positive with mild to moderate to high to very high telomerase activity respectively. Seven (12.7%) samples of apparently normal cervical scrapes were weakly positive for telomerase activity. We observed a good correlation (Po0.001) between telomerase activity and HR-HPV 16/18 positivity with a sensitivity of 88.1% for HPV and 100% for telomerase activity. It is suggested that telomerase activity may be used as an adjunct to cytology and HPV DNA testing in triaging women with cervical lesions.

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confidence: 99%

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

et al. 2006

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“…To solve this problem, we should acknowledge that the classical Koch's postulates are not applicable to ubiquitous viruses that produce a persistent/latent infection. New rules should be considered for these viruses in order to establish their oncogenic role in humans (zur Hausen, 1994Hausen, , 2001Barbanti-Brodano et al, 1998): (i) presence and persistence of the virus or its nucleic acid in tumor cells; (ii) cell immortalization or neoplastic transformation after transfection of the viral genome or its subgenomic fragments; (iii) demonstration that the malignant phenotype of the primary tumor and the modifications induced by transfection of cultured cells depend on specific functions expressed by the viral genome; (iv) epidemiological and clinical evidence that viral infection represents a risk factor for tumor development. This review will show that BKV may fulfill at least the first three criteria and suggest that it may cooperate as a cofactor to the induction or progression of human tumors.…”

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confidence: 99%

Oncogenic transformation by BK virus and association with human tumors

et al. 2003

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BK virus (BKV), a human polyomavirus closely related to JC virus and Simian Virus 40, is ubiquitous in human populations worldwide. After primary infection, BKV establishes a lifelong latent infection in many organs. BKV transforms rodent cells to the neoplastic phenotype and is highly oncogenic in rodents. This review considers the oncogenic potential of BKV in humans and its possible involvement in human tumors. BKV sequences and T antigen (Tag) are detected in several types of human neoplasms, although the viral load is generally low, with less than one copy of the viral genome per cell. The possible causative role of BKV in human oncogenesis rests on the ability of BKV Tag to inactivate the functions of tumor suppressor proteins p53 and pRB family as well as on its ability to induce chromosomal aberrations in human cells. A 'hit and run' mechanism and secretion of paracrine growth factors by BKV Tag-positive cells, recruiting into proliferation neighboring and distant cells, are discussed as possible BKV pathogenic elements in human oncogenesis.

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“…Based on the current understanding, it has been estimated that some 15% of the global cancer burden can be linked to oncogenic tumor viruses [20]. Various in vitro studies have demonstrated that the gene products of CMV are capable of modulating cell cycle progression and apoptosis by regulating the expression of a member of important host genes.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Cytomegalovirus Infection in Patients With Colorectal Cancer by Using PCR Technique

Mehrabani-Khasraghi

Ghane

Ameli

2016

Zahedan J Res Med Sci

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Background: Colorectal cancer is the most common gastrointestinal cancer and the second leading cause of cancer deaths worldwide. Objectives: The purpose of this study is to investigate the prevalence of cytomegalovirus in patients with colorectal carcinomas and polyps in comparison with healthy people. Patients and Methods:In this analytical case-control study, 15 patients with colorectal cancer, 20 patients with colorectal polyps and also 35 patients without malignancy as controls were studied. Biopsy specimens were frozen under sterile conditions at -20ºC. After DNA extraction, analysis of polymerase chain reaction (PCR) to detect CMV DNA in tissue samples was performed. Statistical

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Oncogenic DNA viruses

Cited by 111 publications

References 36 publications

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

Oncogenic transformation by BK virus and association with human tumors

Prevalence of Cytomegalovirus Infection in Patients With Colorectal Cancer by Using PCR Technique

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