Oncogenic BRCA1,2 Mutations in the Human Lineage—A By-Product of Sexual Selection?
Tatyana V. Korneenko,
Nikolay B. Pestov
Abstract:In this review, we discuss the long-known problem of tissue-specific carcinogenesis in BRCA1 and BRCA2 mutation carriers: while the genes are expressed ubiquitously, increased cancer risk is observed mostly in the breast and ovaries, and to a much lesser extent, in some other tissues such as the prostate or pancreas. We reevaluate hypotheses on the evolutionary origin of these mutations in humans. Also, we align together the reports that at least some great apes have much lower risks of epithelial cancers in g… Show more
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