Oncogenetic map of human genome

Verma, Ram S.; Triantafillou, Nicholas G.

doi:10.1016/s0165-4608(97)82239-x

Cited by 14 publications

(3 citation statements)

References 4 publications

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“…Individuals with rare fragile sites (11q13, 12q13, 16q22) in PBL have been reported in the literature who had a breakpoint apparently coincident with a fragile site present in their cancer cells [21]. In our study, a relationship possibly existed between the most frequently observed chromosomal breakpoints and fragile sites, oncogenes, and tumor suppressor gene loci described in the literature [9][10][11] (Table 5).…”

Section: Discussionsupporting

confidence: 63%

“…Involvement of the 11p15 has been described in osteosarcoma secondary to irradiation, suggesting that a fragile site is located at this region, and that radiation or chemotherapy (in our series) may induce chromosome breakage at this band [18]. It is also noteworthy that several oncogenes and tumor suppressor genes map to 11p15 [10,11].…”

Section: Discussionsupporting

confidence: 57%

“…A majority of mapped oncogenes are located at these breakpoints and some of them are known to be activated following chromosomal rearrangements. Fragile sites have also been implicated, because they mostly involve the same bands as cancer breakpoints or those near to oncogene and tumor suppressor gene loci [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nonclonal Chromosomal Aberrations Induced by Anti-Tumoral Regimens in Childhood Cancer

Mesa

Sierrasesúmaga

Calasanz

et al. 2000

Cancer Genetics and Cytogenetics

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Cytogenetic studies were performed on 80 pediatric cancer patients to observe the chromosomal damage, both quantitative and qualitative, induced by chemotherapy. Peripheral blood lymphocytes (PBL) (n = 127) were obtained at diagnosis, during treatment, at remission, and at relapse, and chromosome analysis performed utilizing Gbanding standard procedures. The results show a significant increase in the number of altered karyotypes (P = 0.03) in the samples during treatment, returning to values that were similar to those at diagnosis at 2-year remission. Most of the chromosomal aberrations (CA) detected during the chemotherapy regimens were nonclonal, unbalanced (75%), and involved chromosomes 1, 3, 5, 6, 11, 12, 16, and 17 most frequently. There was also a marked increase of CA in samples at relapse with very similar features (type and distribution) to those detected during treatment. There was a good correlation between the chromosomal breakpoints in our series and fragile sites (58%), oncogene (75%), and tumor suppressor gene (33%) loci described in the literature. The results obtained suggest that cytostatic drugs induce a transient increase in chromosome fragility occurring at several cancer-associated breakpoints.

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