“Oncofertility” procedures in children and adolescents

Tarasiewicz, Marta; Martynowicz, Iwo; Knapp, Paweł; Sieczyński, Piotr

doi:10.5114/pedm.2019.87710

Cited by 8 publications

(5 citation statements)

References 50 publications

(56 reference statements)

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“…Systemic symptoms caused by the disease have an impact on the reproductive potential in several ways, highlighting severe malnutrition and fever (especially in Hodgkin's lymphoma), which promote alterations in spermatogenesis and changes in sperm motility, morphology and concentration, respectively [16,17].…”

Section: Effects Of Cancer On Fertilitymentioning

confidence: 99%

Oncofertility in pediatric patients: current perspectives

Marques¹,

Oura

Dionísio³

et al. 2022

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Cancer treatments may affect fertility in different ways. Oncofertility, i.e. the study of interactions between cancer, anti-cancer therapy, fertility, and reproductive health, is an emerging field that addresses cancer patients' concerns regarding their future reproductive ability. As the number of cancer survivors increases, fertility preservation is becoming an important quality of life issue for many survivors of childhood cancer. There is a wide array of fertility preservation options according to gender and pubertal status, and shared decisions must take place at the time of diagnosis. Even though there might be several barriers that can negatively affect this process, the presence of a dedicated fertility preservation team may help overcome them. In this article, the authors aim to characterize what oncofertility is, the effects of cancer and its treatments on the fertility potential of pediatric patients and also on their mental health. Another goal is to expose the different fertility preservation therapeutic options and potential barriers.

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Section: Effects Of Cancer On Fertilitymentioning

confidence: 99%

Oncofertility in pediatric patients: current perspectives

Marques¹,

Oura

Dionísio³

et al. 2022

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“…Other emerging opportunities, including ovarian cortex freezing and freezing of testicular tissue, are mainly indicated in prepubertal or adolescent subjects, when the incidence of melanoma is very rare [39,40]. For details on these latter techniques, readers can consult a recent comprehensive review [41].…”

Section: Fertility Preservationmentioning

confidence: 99%

Fertility preservation for patients with melanoma

et al. 2022

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The advent of immunotherapy and targeted therapy has outstandingly improved the prognosis in subjects with melanoma. Their use is now advocated also in earlier stages as an adjuvant therapy, and some neoadjuvant clinical trials are ongoing. Consequently, survivors free of disease are increasing, as well as those exposed to these new agents. Parenthood in survivors is, therefore, receiving growing interest. Evidence on the effects of immunotherapy and targeted therapy on future fertility is limited, but not entirely reassuring, in particular for immunotherapy. The necessity of delaying pregnancy seeking up to the end of treatments and follow-up (iatrogenic aging) is an additional albeit neglected source of concern, in particular for women in their late 30s. Subjects with melanoma should be informed on the multifaceted issue of future fertility at the time of cancer diagnosis. Available options of fertility preservations, including sperm and oocytes storage, should also be discussed, especially considering that at the age 0-39, melanoma represents the second most frequent neoplasia. In the decision-making process, most attention should be given to sex, age, and exposure to immunotherapy.

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“…On the other hand, in pre-pubertal girls, oncological treatments can lead to a subsequent absence of the menarche. To improve the lives of these patients, it is necessary to use cryopreservation techniques to preserve their fertility [ 5 ].…”

Section: The Challenge Of Female Fertility Preservationmentioning

confidence: 99%

Oocyte Biobanks: Old Assumptions and New Challenges

Tozzo

2021

BioTech

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The preservation of fertility is a clinical issue that has been emerging considerably in recent decades, as the number of patients of childbearing age who risk becoming infertile for many reasons is increasing. The cryopreservation technique of oocytes has been developed for many years and nowadays constitutes a method of safe storage with impressive efficacy and high rates of successful thawing. The storage and use for research of oocytes taken for medical or non-medical can be carried out by both public and private structures, through egg sharing, voluntary egg donation and so-called “social freezing” for autologous use. This paper focuses on the oocyte bank as an emerging cryopreservation facility, in which a collaboration between public and private and the creation of a network of these biobanks can be useful in enhancing both their implementation and their functions. Good oocyte biobank practice would require that they be collected, stored, and used according to appropriate bioethical and bio-law criteria, collected and stored according to procedures that guarantee the best preservation of their structural components and a high level of safety, connected with appropriate procedures to protect the rights and privacy of the parties involved and associated with the results of the bio-molecular investigations that will be carried out gradually.

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“Oncofertility” procedures in children and adolescents

Cited by 8 publications

References 50 publications

Oncofertility in pediatric patients: current perspectives

Oncofertility in pediatric patients: current perspectives

Fertility preservation for patients with melanoma

Oocyte Biobanks: Old Assumptions and New Challenges

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