Oncofertility

Abstract

Adolescents and young adults ages 15 to 39 who are diagnosed with cancer (AYA survivors) undergo a range of therapies for cancer cure, but subsequently may be at risk of treatment-related infertility and, for female AYA survivors, adverse pregnancy outcomes. Future fertility is important to AYA survivors. Meeting their fertility goals requires awareness of this importance, knowledge of cancer treatment-related fertility risks, appropriate fertility counseling on these risks, and access to fertility care. Epidemiologic and dissemination and implementation research are needed to estimate more precise risks of traditional and novel cancer therapies on fertility and pregnancy outcomes and improve the delivery of fertility care.

Verteporfin Is a Promising Anti-Tumor Agent for Cervical Carcinoma by Targeting Endoplasmic Reticulum Stress Pathway

“…However, cervical carcinoma is still the second most common cancer and the most frequent cancer inducing the death of female in 42 middle-and low-income countries (17). A great deal of attention has been paid to the fertility problems of cancer patients at child-bearing age (18), including cervical carcinoma. Although platinum-based chemotherapy strategy, like cisplatin, can alleviate the condition of cervical cancer, it still causes significant side effects (19) and accompanies with obvious reproductive toxicity and genotoxicity, such as a significant decrease and maturation arrest in germ cells (20), oocyte apoptosis in human ovary (21), amenorrhea or azoospermia (22).…”

Fertility-Sparing Methods in Adolescents Affected by Endometrial Cancer: A Comprehensive Review

“…Transplantation of frozen-thawed ovarian cortical tissue was demonstrated to provide recovery of ovarian functions and to restore spontaneous fertility. Successful hormonal stimulation with gonadotropins and in vitro fertilization have been reported in women who underwent retransplantation of ovarian tissue (so far, more than 200 live births worldwide) [ 27 , 86 , 87 , 91 , 92 ]. Initial reports on pregnancies resulting from transplanting ovarian tissue that was sampled and frozen in prepubertal years have also begun to appear [ 93 ].…”

“…Regardless of their affliction, prognosis, and treatment, many AYAs diagnosed with cancer express a desire to have children in the future [ 25 , 26 ]. These patients rank having children among their top three life goals, along with health and education [ 27 ]. The improvement of treatment and survival of pediatric oncology patients has made the preservation of fertility a central survivorship issue [ 19 ].…”

“…Delivery of medical information before and during medical treatment is an essential duty of physicians. When a patient is incompetent or younger than the legal age, a legal guardian has the responsibility to decide on medical care [ 25 , 27 , 28 ]. Uncertainty occurs about how much adolescents should be involved in their disease management [ 25 ].…”

Besonderheiten und Herausforderungen junger Krebsüberlebender

“…Durch den Verlust der Haare, durch Amputationen und auch Gewichtsschwankungen kann die Entwicklung des Körperbilds, die sexuelle Identität und auch die Sexualität negativ beeinflusst werden [26]. Eine entstandene Infertilität kann angesichts der oft noch nicht begonnenen oder abgeschlossenen Familienplanung besonders belastend für junge Erwachsene mit Krebs sein und sich maßgeblich auf das psychische Befinden und die Partnerschaft auswirken [13]. Generell können die sozialen Beziehungen der AYA mit Krebs durch Prioritätenverschiebung, kommunikative Barrieren und dem Wunsch, andere nicht zu belasten, bei gleichzeitigem Gefühl, nicht verstandenzuwerden,negativ beeinflusst werden [26].…”