Oncocytoma of the lacrimal caruncle and its relevancy to dermatopathology

Jones, Eric T.; Lozeau, Daniel; Lee, Jason B.

doi:10.1111/cup.12647

Cited by 6 publications

(5 citation statements)

References 5 publications

(9 reference statements)

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“…(1,6,7) O crescimento descontrolado dessas células pode caracterizar um oncocitoma, o qual pode ser encontrado em vários órgãos, bem como nos anexos oculares, nos quais geralmente acomete a carúncula, podendo, porém, ocorrer em pálpebras, conjuntiva, saco lacrimal e glândula lacrimal. (2,5) Oncocitomas localizados em carúncula já foram descritos nas últimas décadas, (2,4,5,(7)(8)(9)(10) porém continuam sendo raros de serem encontrados na prática clínica diária, visto que representam menos de 1% de todas as amostras patológicas relacionadas a anexos oculares. (5) Entretanto, são mais prevalentes em pacientes idosos e do sexo feminino, assim como o caso descrito no presente trabalho, devendo ser sempre considerado um diagnóstico diferencial em pacientes com essas características.…”

Section: Discussionunclassified

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Oncocitoma em carúncula: relato de caso

Hirt¹,

Worma²,

Rastelli³

et al. 2021

Revista Brasileira De Oftalmologia

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Section: Discussionunclassified

“…(3) Clinicamente, é frequentemente confundido com hemangiomas, nevos e cistos. (7) Neste relato de caso, são abordadas informações como sintomas, diagnóstico e tratamento. A coleta e a avaliação de informações protegidas de saúde do paciente neste estudo aderiram aos princípios da Declaração de Helsinque.…”

Section: Introductionunclassified

Oncocitoma em carúncula: relato de caso

Hirt¹,

Worma²,

Rastelli³

et al. 2021

Revista Brasileira De Oftalmologia

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“…This report builds on a table initially provided by Say et al 1 and includes all new cases reported within the past 11 years (Table 1). Thirty-seven cases 3,7–34 were obtained for inclusion through a PubMed literature search with the following key words: ocular oncocytoma, lacrimal oncocytoma, oncocytoma caruncle, oncocytoma eyelid, orbital oncocytoma, and eye oncocytoma.…”

Section: Discussionmentioning

confidence: 99%

Unusual Case of a Caruncular Oncocytoma

Vaidya

Simpson

Phillips

et al. 2021

The American Journal of Dermatopathology

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Oncocytomas are benign neoplasms that are most often found in the salivary glands and kidneys. Ocular oncocytoma typically present as an asymptomatic dark blue papule on the lacrimal caruncle. Histologically, the tumor is composed of oncocytes, cells notable for eosinophilic cytoplasmic granules representing large quantities of dysfunctional mitochondria. The neoplastic proliferation may be partially or totally encapsulated and may be surrounded by myoepithelial cells. Discussed is the pathophysiology and histopathology of an ocular oncocytoma from the right lacrimal caruncle of a 68-year-old man. The patient complained of a foreign body sensation and tearing associated with a purpuric 1 • 1-mm papule of the right caruncle that had been present for 6 months. An excisional biopsy showed an oxyntic neoplasm with small cystic glandular spaces associated with goblet cells and mucin, confirmed by mucicarmine stain. Given the rarity of ocular oncocytomas and presence of mucin, exclusion of an endocrine mucin-producing sweat gland carcinoma was necessary. Peripheral myoepithelial cells noted on p63 immunostaining are seen in both endocrine mucinproducing sweat gland carcinoma and oncocytomas. However, endocrine mucin-producing sweat gland carcinoma is excluded by the presence of goblet cells, the uniform oxyphilic cytoplasm of the epithelial cells, and the negative immunohistochemical staining for neuron-specific enolase, chromogranin, synaptophysin, estrogen receptor, and progesterone receptor. Complete surgical excision is the treatment of choice for oncocytomas. This case highlights the clinical and histopathological presentation of ocular oncocytomas and raises awareness of this rare entity for both the practicing dermatologist and dermatopathologist.

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“…Paraffin sections stained positive by immunohistochemistry for mES13, a mitochondrial antibody. Additional cutaneous tumors reported to show oncocytic change include cutaneous oncocytomas, periocular oncocytoma, lacrimal caruncle oncocytoma, melanocytic nevi, an eccrine acrospiroma of the eyelid and a porocarcinoma . The oncocytic change in these neoplasms usually occurs focally, and is only rarely present throughout the entire lesion.…”

Section: Discussionmentioning

confidence: 99%

“…However, a few cutaneous neoplasms with oncocytic change have been reported in the literature, most of which have been benign tumors. These reports include cases of cutaneous oncocytoma, periocular oncocytoma, oncocytoma of the lacrimal caruncle, melanocytic nevi, eccrine acrospiroma and a porocarcinoma . Herein, we report the case of a 70‐year‐old male patient with an oncocytic hidradenoma which occurred on the left scalp, and clinically was thought to be a basal cell carcinoma (BCC).…”

Section: Introductionmentioning

confidence: 99%

A rare case of cutaneous oncocytic hidradenoma

Reddy

Chong

2017

J Cutan Pathol

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Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Oncocytomas, or tumors composed primarily of oncocytes, are typically found in the kidneys. Other common sites include the salivary, thyroid, and parathyroid glands. Oncocytic metaplasia has only been rarely reported in various cutaneous neoplasms. We report a case of an elderly male presenting with a 5 mm erythematous papule on his left scalp, who underwent a shave biopsy showing a nodular, dermal-based adnexal tumor with prominent ductal differentiation, composed of multiple small, well-formed lumina surrounded by enlarged and bland-appearing epithelioid cells. Cytokeratin 7 (CK7), epithelial membrane antigen (EMA) and monoclonal carcinoembryonic antigen (mCEA) immunohistochemical stains were positive, consistent with adnexal differentiation. Phosphotungstic acid-hematoxylin (PTAH) and Luxol fast blue (LFB) stains highlighted the cytoplasmic granules, consistent with mitochondria. The overall findings were consistent with an oncocytic nodular hidradenoma. Oncocytic hidradenoma is a very rare entity, with only 1 previously reported case in the literature.

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Oncocytoma of the lacrimal caruncle and its relevancy to dermatopathology

Cited by 6 publications

References 5 publications

Oncocitoma em carúncula: relato de caso

Oncocitoma em carúncula: relato de caso

Unusual Case of a Caruncular Oncocytoma

A rare case of cutaneous oncocytic hidradenoma

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