Oncocytoma: An uncommon lesion for adrenal gland

Nova, José Luis Muñoz de; García-Sanz, Íñigo; Val, Lourdes del Campo; Valdueza, Jesús Delgado; Martín-Pérez, Elena

doi:10.1016/j.endoen.2015.02.006

Cited by 3 publications

(5 citation statements)

References 10 publications

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“…On CT, usually adrenal oncocytic neoplasms present as round or ovoid, solid, well-defined, and usually encapsulated masses with dimensions around 8 cm [ 3 ]. After contrast administration, they tend to have a progressive and heterogeneous enhancement, and they usually lack a central scar, which is seen on most renal oncocytomas [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Calretinin is used to differentiate cortical lesions from those of the adrenal medulla, like pheochromocytomas [ 4 ]. The Lin-Weiss-Bisceglia Criteria is a morphologic classification proposed to differentiate malignant from benign adrenal oncocytic lesions [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Accurate pathological classification of adrenal oncocytic neoplasms is crucial for the patient's prognosis, and it is based upon the Lin-Weiss-Bisceglia Criteria [ 3 ]. Most adrenal oncocytic lesions are benign and can be assessed conservatively with a radiological follow-up of five years, usually with no signs of recurrence [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…To date, only around 150 cases have been described [ 3 ]. There is no precise age distribution, with a tendency to be more frequent in females and in the left adrenal gland [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Incidental Adrenal Masses: A Case Report of an Adrenal Oncocytoma

Giesteira,

Sousa,

Pinheiro Amorim

2023

Cureus

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A 59-year-old woman underwent an abdominal and pelvic computed tomography (CT) scan to rule out non-obstructive urolithiasis. The patient was asymptomatic, with the exception of occasional bilateral low back pain. A physical examination did not reveal any notable findings. The CT scan revealed the presence of an incidental solid left adrenal lesion, which displaced the body of the pancreas and the left kidney. The lesion measured 7 cm × 6.5 cm and exhibited a rounded morphology with well-defined margins. It showed progressive and heterogeneous contrast uptake. Additionally, magnetic resonance imaging (MRI) was performed, confirming the presence of an adrenal lesion with intense and heterogeneous hypersignal on T2. The lesion also demonstrated heterogeneous and persistent enhancement in a dynamic study. Furthermore, there were some indistinct and non-specific hypointense areas identified on both T1 and T2 sequences. The lesion exhibited moderately restricted diffusion. Although the imaging features were non-specific, there were no indications of invasion or distant metastasis, which made a benign large adrenal mass the most likely diagnosis. Non-functioning pheochromocytoma, lipid-poor adrenal adenoma, as well as metastasis or primary adrenal carcinoma, were considered differential diagnoses. The patient underwent an elective adrenalectomy, during which the identified lesion was completely resected. The patient's postoperative recovery was uneventful, and she was discharged three days after the procedure. Subsequent histopathological evaluation revealed an oncocytic neoplasm of the adrenal cortex - specifically, an oncocytoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…To date, only around 150 cases have been described [ 3 ]. There is no precise age distribution, with a tendency to be more frequent in females and in the left adrenal gland [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incidental Adrenal Masses: A Case Report of an Adrenal Oncocytoma

Giesteira,

Sousa,

Pinheiro Amorim

2023

Cureus

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“…Despite this fact, an adrenal oncocytoma is usually benign. Approximately, 25% of AOs reported in the literature are malignant, but in some recent series, a percentage greater than 60-70% have been found [ 11 ]. Also, AO has been reported to be associated with hormonal hypersecretion in 31.5% of cases, principally as a Cushing's syndrome, virilizing syndrome, or pheochromocytoma-like syndrome [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Oncocytic Tumors: An Uncommon Benign Adrenal Gland Lesions With Features of Malignancy

Elazime¹,

Elazizi²,

Aynaou³

et al. 2023

Cureus

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Oncocytic cell neoplasms are usually found in the thyroid or salivary glands and the kidneys. Adrenal oncocytoma (AO) is an extremely rare localization. It is often non-functional and the suspicion of malignancy is considered when the size of an adrenal incidentaloma is greater than 4 cm. These adrenal oncocytomas, however, are large, round, and encapsulated with a benign presentation and evolution.We report on a 40-year-old male patient. Upon suspicion of a SARS-CoV-2 infection, the general physician instructed a chest CT scan, which, fortuitously, revealed a suspicious left adrenal lesion measuring 62x45mm. A biochemical investigation was negative for either pheochromocytoma or Cushing's syndrome, allowing the recommended surgery to be performed. The anatomopathological analysis showed an uncommon benign adrenal lesion, an adrenal oncocytoma.

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Adrenocortical oncocytoma

Hong

Hao²,

Hu³

et al. 2017

Medicine

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Rationale:Adrenocortical oncocytoma is an extremely rare tumor of the adrenal gland. Its diagnostic criteria and biological behavior has not yet reached a consensus. The purpose of this study is to investigate the clinical characteristics of adrenocortical oncocytoma.Patient concerns:The clinical data from 11 cases of adrenocortical oncocytoma were retrospectively analyzed. Five patients found the tumor incidentally during the healthy examination, and 3 cases found the tumor during the diagnostic work-up for the evaluation of flank pain or hypertension. A female patient manifested virilization, and Cushing's syndrome showed in two patients. The tumor diameter was ranging from 2.0-13.0 cm.Diagnoses:The serum cortisol, plasma aldosterone and catecholamine metabolites were used to evaluate the function of the tumors, and enhanced CT scan was used to confirm the tumor boundary, enhancement, and lymph nodes condition.Interventions:Seven cases underwent laparoscopic adrenal tumor resection, 4 patients underwent open surgery. Pathological report indicated adrenocortical oncocytoma in all cases, three of which were potentially malignant.Outcomes:The patients were followed up for 19-72 months, no local recurrence and distant metastases were detected in 3 cases of malignant potential cases.Lessons:The majority of adrenocortical oncocytoma with or without function are benign, and close follow-up observation is essential.

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Oncocytoma: An uncommon lesion for adrenal gland

Cited by 3 publications

References 10 publications

Incidental Adrenal Masses: A Case Report of an Adrenal Oncocytoma

Incidental Adrenal Masses: A Case Report of an Adrenal Oncocytoma

Oncocytic Tumors: An Uncommon Benign Adrenal Gland Lesions With Features of Malignancy

Adrenocortical oncocytoma

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