Oncocytic adrenocortical neoplasms—a clinicopathologic study of 13 new cases emphasizing the importance of their recognition

Wong, Daniel; Spagnolo, Dominic V.; Bisceglia, Michele; Havlat, Marek; McCallum, Dugald; Platten, Michael

doi:10.1016/j.humpath.2010.08.010

Cited by 122 publications

(160 citation statements)

References 22 publications

(39 reference statements)

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“…Concerning the importance of histological variant in ACC clinical outcome, we have confirmed the results of a retrospective survival analysis provided by Wong et al [26], in which was shown a better prognosis for malignant adrenocortical neoplasm showing predominant oncocytic features in comparison with those of classical type. The prognostic value of miR-210 has already been demonstrated in breast [33], pancreatic [34], head and neck carcinomas [35], pediatric osteosarcoma [36], and glioblastoma [37].…”

Section: Differential Expression Of Mirnas Investigated In Adenoma Vssupporting

confidence: 88%

“…As expected, we found a strong reciprocal correlation among miR-483-3p and miR-483-5p (r= 0.7380, p=<0.0001). Moreover, we found a significantly lower expression in the oncocytic variant of adrenocortical carcinoma, whose meaning remains to be defined, but supports a different and specific phenotype also at the molecular level for this special type [10,26]. Interestingly, high miR-493-3p levels were also a feature of low proliferating tumors.…”

Section: Differential Expression Of Mirnas Investigated In Adenoma Vssupporting

confidence: 66%

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MicroRNA expression patterns in adrenocortical carcinoma variants and clinical pathologic correlations

et al. 2014

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Section: Differential Expression Of Mirnas Investigated In Adenoma Vssupporting

confidence: 88%

Section: Differential Expression Of Mirnas Investigated In Adenoma Vssupporting

confidence: 66%

MicroRNA expression patterns in adrenocortical carcinoma variants and clinical pathologic correlations

et al. 2014

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“…Most of them are incidentally detected [13][14][15][16][17][18] , since only 17% are functional adrenal masses [19] . Their occurrence in all ages has been described, without a precise age distribution (mean age at diagnosis 47 years, range 27-72 years), and have been observed to occur more frequently in females (2.5: 1) and in the left gland (3.5: 1).…”

Section: Incidencementioning

confidence: 99%

Adrenal Oncocytic Neoplasm: A Systematic Review

Mearini¹,

Sordo

Costantini³

et al. 2012

Urol Int

151

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Introduction: Oncocytic neoplasms as tumors arising in the adrenal glands are rare, usually considered as nonfunctional and benign. In the current literature, there are extremely limited reports of adrenal oncocytic neoplasms; as to date, only 147 cases have been described. The rarity of the event prompted this study which reviews and presents the incidence, histology, diagnosis and therapy of adrenal oncocytic neoplasms. Materials and Methods: A review by systematic literature search was done using the MEDLINE®/Cochrane libraries from 1950 to date using the medical subject headings ‘oncocytoma', ‘adrenal gland', ‘adrenal oncocytoma', ‘adrenal oncocytic neoplasm' and ‘adrenal oncocytic carcinoma'. Results: Adrenal oncocytic neoplasm is a rare disease, usually incidentally detected because only 17% are functional adrenal masses. The typical oncocyte displays abundant granular eosinophilic cytoplasm, due to the accumulation of mitochondria. Computed tomography and magnetic resonance imaging are not able to identify or differentiate benign and malignant oncocytic neoplasms. The mainstay of therapy is adrenalectomy, recently performed by laparoscopy. The prognosis is good for benign tumors, while adrenocortical oncocytic carcinoma has a poor survival rate of only 5 years. Conclusions: Adrenal oncocytic neoplasm, a rare and mostly benign tumor, usually presents as an incidental, large adrenal mass; surgery is the mainstay of therapy, by means of laparoscopy which is now the most diffuse approach to adrenalectomy.

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“…Therefore, the cutoff values validated for conventional adrenocortical carcinoma may lead to an overdiagnosis of malignancy in this special group. Modified scoring systems which separately analyze "major" (mitotic index, atypical mitoses, and venous invasion) and "minor" (necrosis, capsular and sinusoidal invasion, size >10 cm, and weight >200 g) criteria have therefore been proposed to define three groups of tumors (benign, borderline, and malignant) that possess distinct clinical behavior [52].…”

Section: Oncocytic Tumorsmentioning

confidence: 99%

The Weiss Score and Beyond—Histopathology for Adrenocortical Carcinoma

et al. 2011

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The pathological diagnosis of adrenocortical carcinoma (ACC) is still challenging for its rarity and the presence of special variants (pediatric, oncocytic, myxoid, and sarcomatoid). It is based on the recognition at light microscopy of at least three among nine morphological parameters, according to the Weiss scoring system, which has been introduced 27 years ago and nowadays is the most widely employed. Nevertheless, the diagnostic performance of this system is very high but does not reach a sensitivity and specificity of 100%, its diagnostic applicability is potentially low among non-expert pathologists, and a group of borderline cases with only one or two criteria exist of uncertain behavior. Moreover, it is scarcely reproducible in the ACC morphological variants. In fact, specifically for the pure oncocytic neoplasms that seem to have a better prognosis in comparison to the conventional ACCs, a modified system (the Lin-Weiss-Bisceglia) has been proposed. With the aim to simplify the ACC diagnosis, 2 years ago, the "reticulin" diagnostic algorithm has been proposed, based on the observation that the tumoral reticulin framework (highlighted by reticulin silver-based histochemical staining) is consistently disrupted in malignant cases but only in a small subset of benign cases. Following this algorithm, in the presence of reticulin alterations, malignancy is further defined through the identification of at least one of the following parameters: necrosis, high mitotic rate, and venous invasion. As a complement to the morphological approach, some immunohistochemical markers (such as steroidogenic factor 1) have been proposed as diagnostic and prognostic adjuncts but still lack wide clinical validation.

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Oncocytic adrenocortical neoplasms—a clinicopathologic study of 13 new cases emphasizing the importance of their recognition

Cited by 122 publications

References 22 publications

MicroRNA expression patterns in adrenocortical carcinoma variants and clinical pathologic correlations

MicroRNA expression patterns in adrenocortical carcinoma variants and clinical pathologic correlations

Adrenal Oncocytic Neoplasm: A Systematic Review

The Weiss Score and Beyond—Histopathology for Adrenocortical Carcinoma

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