Once weekly total and subtotal skin electron beam therapy for Kaposi's sarcoma

Nisce, Lourdes Z.; Safai, Bijan; Poussin-Rosillo, Hipolito

doi:10.1016/0360-3016(79)90385-7

Cited by 7 publications

(8 citation statements)

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“…The choice of radiotherapy is based on the site, extent, thickness and depth of the lesions. This modality is of proven effectiveness, tolerability and durability, even in heavily pretreated patients [28][29][30]. Our own experience confirms these findings.…”

Section: Discussionsupporting

confidence: 80%

Classical Kaposi’s Sarcoma in Caucasians in Africa – Experience at the Johannesburg Hospital (1978–1992)

Stein¹,

Kantor²,

Spencer³

et al. 1994

Dermatology

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The data are scant concerning classical Kaposi’s sarcoma (CKS) among the Caucasian population of Africa. A description of the clinical features of 15 such patients, treated and followed up at the Johannesburg General Hospital over a 14-year period (1978–1992) is presented. All patients were negative for the human immunodeficiency virus. After a mean follow-up of 50 months (range: 7–168 months), 2 patients are alive with absent or minimal disease; 1 patient is alive with stable disease and 1 has active disease involving his extremities. Three patients were lost to follow-up but had minimal or no disease when last seen. Five patients died of unrelated causes but also had minimal or no disease at their last visit. One patient died of sepsis related to active KS. Only two patients died of progressive KS. No alterations in humoral or cellular immunity were demonstrated in 2 patients with persistent disease. Four (27%) patients developed lymphoproliferative disorders including non-Hodgkin’s lymphoma, Walden-ström’s macroglobulinemia, Hodgkin’s disease and Castleman’s disease (angio-follicular lymph node hyperplasia) preceding or following the diagnosis of CKS. These data confirm the indolent nature and good outcome of the classical form of Kaposi’s sarcoma among Caucasians in the southern African region. The marked association between CKS and lymphoproliferative disorders warrants a long-term awareness and continued monitoring for these complications.

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Section: Discussionsupporting

confidence: 80%

Classical Kaposi’s Sarcoma in Caucasians in Africa – Experience at the Johannesburg Hospital (1978–1992)

Stein¹,

Kantor²,

Spencer³

et al. 1994

Dermatology

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“…Early, vascular KS lesions appear to be treated more effectively with radiation therapy than lesions that are older and indurated. 86 Disseminated KS is treated with chemotherapy; doxorubicin, bleomycin, and vincristine, with a total response rate of 88%, seems to have the best efficacy with the least toxicity. 84,87 Alpha-interferon has also had varied success (20 to 50%) but is not as efficacious in patients with CD4 counts of less than 600.…”

Section: Neoplasms Kaposi's Sarcomamentioning

confidence: 99%

Urologic Problems in Patients with Acquired Immunodeficiency Syndrome

Staiman

Lowe

2004

The Scientific World JOURNAL

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“…Bu modaliteler arasında en sık kullanılan, en etkin kontrol sağlayan güvenilir tedavi şekli RT' dir [5,7,[11][12][13][14]. KS'nin yaygın yüzeyel cilt lezyonları oldukça radyoduyarlı olduğundan tam cevap oranları yüksektir [5,15].…”

Section: Bulgularunclassified

“…KS tedavisi; lokal eksizyon, kriyoterapi, kemoterapi, immünoterapi ve radyoterapi gibi farklı modaliteler ile olabilmektedir [10,11]. Bu modaliteler arasında en sık kullanılan, en etkin kontrol sağlayan güvenilir tedavi şekli RT' dir [5,7,[11][12][13][14]. KS'nin yaygın yüzeyel cilt lezyonları oldukça radyoduyarlı olduğundan tam cevap oranları yüksektir [5,15].…”

Section: çAlışmaya Dicle üNiversitesi Hastanesi Radyasyonunclassified

Kaposi sarkomu nedeniyle radyoterapi uygulanan 14 hastanın değerlendirilmesi

et al. 2015

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Objective: In our study, we evaluated the clinical characteristics and outcomes of treatment in patients with Kaposi's sarcoma (KS). Methods:The patients undergoing radiotherapy (RT) because of the KS between the years 2005-2012 in Radiation Oncology Department of Dicle University Hospital were included. All patients underwent RT with different dose-fractionation schemes to increase quality of life and to palliate the symptoms. Patients with lesions in multiple regions underwent RT in the same or different dates. Responses to radiotherapy were recorded as complete or partial response.Results: Fourteen patients received radiotherapy because of f KS were evaluated retrospectively. Twenty two different regions of 14 patients underwent RT . Only one patient (4.5%) was performed RT to glans penis as a third region while performed to the two regions in six patients (27.3%). At irradiations, 6 MV and 10 MV photon energies with 6 MeV, 9 MeV and 12 MeV electron energy were used. Water phantom or bolus material was used to obtain a homogeneous dose distribution in the photon irradiation. RT dose administered to a total of 22 different regional was median 800 cGy (Range: 800-3000 cGy). Median number of RT fractions was 1 (Range: 1-10).When treatment response were evaluated stable disease was present in the 4 (18.1%) regions. Partial response was achieved in eight (36.4%) regions, complete response in 10 (45.5%). RT-related common lymphedema in the feet and legs was observed in the four (57.3%) regions in the acute period. Complication of pain was present in two (28.7%) regions. Conclusion:RT is an appropriate and effective treatment regimen in the palliative treatment of KS lesions. Excellent response rates of skin lesions may be obtained by RT. Lesions and symptoms such as itching may be lost after RT. Side effects such as edema and pain may be relieved by supportive treatment. Bulgular: KS nedeniyle radyoterapi uygulanan 14 hasta retrospektif olarak değerlendirildi. On dört hastanın toplam 22 farklı bölgesine RT uygulandı. Altı hastada (%27,3) iki ayrı bölge ışınlanırken, yalnız bir hastada (%4,5) üçüncü bölge olarak glans penisteki lezyona RT uygulandı. Işınla-malarda 6 MV ve 10 MV foton enerjileri ile 6 MeV, 9 MeV ve 12 MeV elektron enerjileri kullanıldı. Foton ışınlamala-rında homojen doz dağılımı elde etmek için su fantomu veya bolus materyali kullanıldı. Uygulanan RT dozu toplam 22 farklı bölge için medyan 800 cGy (800-3000 cGy) idi. RT fraksiyon sayısı medyan 1'di (1-10). Tedavi yanıt-ları değerlendirildiğinde 4 (%18,1) bölgede stabil hastalık mevcuttu. Sekiz (%36,4) tedavi bölgesinde kısmi cevap sağlanırken, 10 (%45,5) bölgede de tam cevap elde edildi. Dört (%57,3) tedavi bölgesinde RT' ye bağlı ayaklarda ve bacaklarda akut dönemde yaygın lenfödem gözlendi. İki (%28,7) bölgede ise ağrı komplikasyonu mevcuttu.Sonuç: RT, KS lezyonlarının palyatif tedavisinde uygun ve etkili bir tedavi rejimidir. RT ile cilt lezyonlarında mü-kemmel cevap oranları elde edilebilir. RT sonrası lezyonlar ve kaşıntı gibi şikayetle...

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Once weekly total and subtotal skin electron beam therapy for Kaposi's sarcoma

Cited by 7 publications

References 0 publications

Classical Kaposi’s Sarcoma in Caucasians in Africa – Experience at the Johannesburg Hospital (1978–1992)

Classical Kaposi’s Sarcoma in Caucasians in Africa – Experience at the Johannesburg Hospital (1978–1992)

Urologic Problems in Patients with Acquired Immunodeficiency Syndrome

Kaposi sarkomu nedeniyle radyoterapi uygulanan 14 hastanın değerlendirilmesi

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