Once-weekly dose of 8400 IU vitamin D3 compared with placebo: effects on neuromuscular function and tolerability in older adults with vitamin D insufficiency

Lips, Paul; Binkley, Neil; Pfeifer, Michael; Recker, Robert R.; Samanta, Suvajit; Cohn, Dosinda; Chandler, Julie; Rosenberg, Elizabeth; Papanicolaou, Dimitris A.

doi:10.3945/ajcn.2009.28113

Cited by 109 publications

(134 citation statements)

References 34 publications

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“…In a randomized controlled trial using weekly doses of 8400 IU of vitamin D 3 , incidences of hypercalcemia and hypercalciuria were reported to be insignificant comparing with placebo group, with no kidney stone formation. (17) Clinical trials in LTC settings adopting standard 800-1000 IU of vitamin D 2 reported to have no adverse outcomes. (18) In a recent publication summarizing clinical practice guidelines updated by American Geriatrics Society and British Geriatrics Society on fall prevention, it was strongly recommended that daily vitamin D supplementation of 800 IU shall be considered in LTC residents who are known to be vitamin D deficient, having gait or balance problems, and who are at risk for falls.…”

Section: Introductionmentioning

confidence: 99%

Association Between Vitamin D Dosing Regimen and Fall Prevention in Long-term Care Seniors

Chua¹,

Wong

2011

Can Geri J

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IntroductionThe effectiveness of vitamin D in reducing falls among longterm care (LTC) seniors remains nonconclusive. We reviewed how vitamin D dosing regimen could affect rate of fall and number of fallers among LTC seniors.MethodsWe conducted a systematic literature review. Studies were selected by two independent reviewers based on study characteristics (age 75 or older), quality assessment (primary analysis randomized controlled trials), and outcome (rate of fall and number of fallers). Analyses of all trials following trials using daily standard dosage (800–1000 IU) only were performed to compare daily standard dosage with intermittent supratherapeutic dosage in fall prevention.ResultsSeventy-nine studies were identified, with 28 selected by reviewers (kappa 0.98), and four RCT were conducted in LTC. Daily standard dosage provides greater reduction in rate of fall by 16%, which was statistically significant. However, reduction in number of fallers remained statistically insignificant even taking dosing regimen into account.ConclusionsDaily standard dosage of vitamin D has greater benefits in reducing fall rate than that of intermittent supratherapeutic doses, but not in number of fallers. This could imply that vitamin D is useful in preventing fall recurrence rather than first fall. Prospective studies randomizing LTC seniors to different dosing regimens are warranted.

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Section: Introductionmentioning

confidence: 99%

Association Between Vitamin D Dosing Regimen and Fall Prevention in Long-term Care Seniors

Chua¹,

Wong

2011

Can Geri J

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“…For example, in individuals with vitamin D deficiency and increased postural sway, treatment with 8,400 IU of vitamin D3 once a week reduced the sway [80]. Evidence from other randomized clinical trials supports that vitamin D supplements improve muscle strength and overall function of the elderly and reduce the risk of falls in the elderly.…”

Section: Persons With Mcdd Have Higher Incidence Of Falls and Fracturesmentioning

confidence: 98%

“…The frequency of falls in the elderly and disabled can be reduced by correcting vitamin D deficiency [80]. Comorbidities, including the consumption of certain medications (e.g., psychotropic drugs), visual and hearing impairment, axial orthopedic disabilities, peripheral nerve dysfunction, balance issues, and muscle weakness, increase fall risks [87].…”

Section: Falls Can Be Reduced With the Correction Of Vitamin D Deficimentioning

confidence: 99%

“…Improving vitamin D status is an important modifiable risk factor for reducing falls and fractures [80], particularly in those with MCDD. Because of the relatively shorter half-life of vitamin D2, vitamin D3 is preferred and should be administered no less frequently than once monthly [8,19].…”

Section: Correcting Vitamin D Deficiencymentioning

confidence: 99%

“…Muscle weakness and sarcopenia have an inverse correlation with serum 25(OH)D levels [80]. There are abundant vitamin D receptors (VDR) in muscle cells that increase with physical activity [121].…”

Section: Common Disorders That Are Aggravated By Vitamin Deficiencymentioning

confidence: 99%

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Vitamin D Adequacy and Improvements of Comorbidities in Persons with Intellectual Developmental Disabilities

Wimalawansa¹

2016

J Child Dev Disord

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The prevalence of vitamin D deficiency is alarmingly high among people with developmental disabilities. In addition to enhancing mineral metabolism, vitamin D affects neuro-modulation, muscle coordination, immunity, infections and autoimmune disorders. Peer-reviewed papers from PubMed, Medline, and other research databases were searched using key words to collate relevant evidence in preparation of this evidence-based review. Per the guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), general interpretations of results are included taking into consideration the risk-benefits, broader evidence, and implications for practicing clinicians. Many clinicians consider the minimum level of serum 25-hydroxy vitamin D [25(OH)D] required for optimal health in the normal population to be 30 ng/mL (75 nmol/L), whereas a lesser number consider the level to be 20 ng/mL. However, evolving data suggest that for vulnerable populations, such as those with autoimmune disease, cancer, cardiovascular diseases, metabolic syndrome, and persons with developmental and intellectual disabilities, 40 ng/mL (100 nmol/L) might be considered the minimum level. To reach this level, most people requires adequate sun exposure and/or a daily oral supplementation of between 1,000 and 5,000 International Units of vitamin D. This review explores vitamin D requirements for the musculoskeletal and non-skeletal systems and its adequacy in relationship to common disorders affecting persons with intellectual disabilities.

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Screening for Vitamin D Deficiency in Adults

Kahwati

LeBlanc

Weber

et al. 2021

JAMA

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IMPORTANCE Low serum vitamin D levels have been associated with adverse clinical outcomes; identifying and treating deficiency may improve outcomes.OBJECTIVE To review the evidence about screening for vitamin D deficiency in adults.DATA SOURCES PubMed, EMBASE, the Cochrane Library, and trial registries through March 12, 2020; bibliographies from retrieved articles, outside experts, and surveillance of the literature through November 30, 2020.STUDY SELECTION Fair-or good-quality, English-language randomized clinical trials (RCTs) of screening with serum 25-hydroxyvitamin D (25[OH]D) compared with no screening, or treatment with vitamin D (with or without calcium) compared with placebo or no treatment conducted in nonpregnant adults; nonrandomized controlled intervention studies for harms only. Treatment was limited to studies enrolling or analyzing participants with low serum vitamin D levels.DATA EXTRACTION AND SYNTHESIS Two reviewers assessed titles/abstracts and full-text articles, extracted data, and assessed study quality; when at least 3 similar studies were available, meta-analyses were conducted.MAIN OUTCOMES AND MEASURES Mortality, incident fractures, falls, diabetes, cardiovascular events, cancer, depression, physical functioning, and infection.RESULTS Forty-six studies (N = 16 205) (77 publications) were included. No studies directly evaluated the health benefits or harms of screening. Among community-dwelling populations, treatment was not significantly associated with mortality (pooled absolute risk difference [ARD], 0.3% [95% CI, −0.6% to 1.1%]; 8 RCTs, n = 2006), any fractures (pooled ARD, −0.3% [95% CI, −2.1% to 1.6%]; 6 RCTs, n = 2186), incidence of diabetes (pooled ARD, 0.1% [95% CI, −1.3% to 1.6%]; 5 RCTs, n = 3356), incidence of cardiovascular disease (2 RCTs; hazard ratio, 1.00 [95% CI, 0.74 to 1.35] and 1.09 [95% CI, 0.68 to 1.76]), incidence of cancer (2 RCTs; hazard ratio, 0.97 [95% CI, 0.68 to 1.39] and 1.01 [95% CI, 0.65 to 1.58], or depression (3 RCTs, various measures reported). The pooled ARD for incidence of participants with 1 or more falls was −4.3% (95% CI, −11.6% to 2.9%; 6 RCTs). The evidence was mixed for the effect of treatment on physical functioning (2 RCTs) and limited for the effect on infection (1 RCT). The incidence of adverse events and kidney stones was similar between treatment and control groups. CONCLUSIONS AND RELEVANCENo studies evaluated the direct benefits or harms of screening for vitamin D deficiency. Among asymptomatic, community-dwelling populations with low vitamin D levels, the evidence suggests that treatment with vitamin D has no effect on mortality or the incidence of fractures, falls, depression, diabetes, cardiovascular disease, cancer, or adverse events. The evidence is inconclusive about the effect of treatment on physical functioning and infection.

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Once-weekly dose of 8400 IU vitamin D3 compared with placebo: effects on neuromuscular function and tolerability in older adults with vitamin D insufficiency

Cited by 109 publications

References 34 publications

Association Between Vitamin D Dosing Regimen and Fall Prevention in Long-term Care Seniors

Association Between Vitamin D Dosing Regimen and Fall Prevention in Long-term Care Seniors

Vitamin D Adequacy and Improvements of Comorbidities in Persons with Intellectual Developmental Disabilities

Screening for Vitamin D Deficiency in Adults

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