Once, twice, or three times daily famciclovir compared with aciclovir for the oral treatment of herpes zoster in immunocompetent adults: a randomized, multicenter, double-blind clinical trial

Shafran, Stephen D.; Tyring, Stephen K.; Ashton, Richard; Decroix, J; Forszpaniak, Chistine; Wade, Alan G; Paulet, C.; Candaele, Daniel

doi:10.1016/s1386-6532(03)00164-1

Cited by 68 publications

(27 citation statements)

References 18 publications

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“…The median time taken for full crusting of the lesions in both the groups was 10 days, According to Shafran et al 8 the median time for full crusting was 10 days in both the groups. Our findings are in agreement with Shafran et al 8 The median time taken for complete healing of the lesions in both the groups was 20days.…”

Section: Figuresupporting

confidence: 93%

“…Hence, we could not compare our observation regarding the efficacy of each drug in reducing the duration of PHN. 8,9 CONCLUSION: Thus in the present study, both Famcyclovir and Valacyclovir have a modest beneficial effect in the treatment of acute herpes zoster if given within 72 hours of onset of rash. Valacyclovir offers significant benefit by providing well tolerated cost effective convenient dosage regime and accelerated rate of resolution of pain compared to Famcylcovir.…”

Section: Figurementioning

confidence: 58%

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A Comparative Study to Evaluate the Efficacy and Safety of Valacyclovir and Famcyclovir in the Management of Herpes Zoster in a Tertiary Care Hospital in Puducherry

Indradevi¹,

Manoharan²,

Oudeacoumar³

et al. 2014

jemds

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Section: Figuresupporting

confidence: 93%

Section: Figurementioning

confidence: 58%

A Comparative Study to Evaluate the Efficacy and Safety of Valacyclovir and Famcyclovir in the Management of Herpes Zoster in a Tertiary Care Hospital in Puducherry

Indradevi¹,

Manoharan²,

Oudeacoumar³

et al. 2014

jemds

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“…Similar efficacy results were found in a larger randomized, multicenter, double-blind study in 559 immunocompetent adults treated for 7 days (treatment initiated within 72 hours of onset of zoster skin lesions) with famciclovir (750 mg once daily, 500 mg twice daily, or 250 mg 3 times daily) or acyclovir (800 mg 5 times daily). 12 Famciclovir, like acyclovir, has also been shown to reduce the duration of postherpetic neuralgia by a median of 2 months. 13 Famciclovir and valacyclovir have similar safety and efficacy in treating herpes zoster.…”

Section: Current Treatments For Herpes Zoster Antiviral Treatmentmentioning

confidence: 99%

Management of herpes zoster and postherpetic neuralgia

Tyring¹

2007

Journal of the American Academy of Dermatology

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“…Shen et al, [7] found the median time taken for full crusting was 11 days in the famciclovir group and 10 days in a cyclovir group. According to Shafran et al, [8] the median time for full crusting was 7 days in both the groups. Our findings are in agreement with Shen et al, The median time taken for complete healing of the lesions in both the groups was 21days.…”

Section: Complicationsmentioning

confidence: 72%

A Comparative Study to Evaluate the Efficacy and Safety of Acyclovir and Famciclovir in the Management of Herpes Zoster

Gopal

Shannoma

Kumar

et al. 2013

JCDR

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Background: Over the years, acyclovir has been the oral antiviral agent approved for the treatment of patients with acute herpes zoster,Its effectiveness in lessening the acute signs and symptoms of herpes zoster has been established but the effects on post herpetic neuralgia are less clear cut. Famciclovir is a new member of guanine nucleoside family of drugs. It is a well absorbed oral form of penciclovir with longer half life. This was a open comparative randomized study carried out to compare the safety and efficacy of famciclovir administered at 250mg thrice daily with acyclovir 800mg five times daily for the treatment of acute uncomplicated herpes zoster in immunocompetent individuals aged above 40 years. AIM:To assess the clinical profile of Herpes zoster, compare the efficacy and safety of acyclovir and famciclovir in the treatment of herpes zoster and to describe the effectiveness of acyclovir and famciclovir preventing post herpetic neuralgia. Methods:A total of 100 newly zoster were randomized in 1:1 ratio into acyclovir and famciclovir groups after inclusion criteria were satisfied.Treatment was initiated within 72 hrs of onset of symptoms and was continued for 7 days and evaluated at the end of each week up to six weeks period for full crusting of the lesions, complete healing of the lesion and loss of acute pain.Results: It was observed that famciclovir was as effective as acyclovir with no significant difference in time taken for full crusting, complete healing of lesions or loss of acute pain. Famciclovir was well tolerated with a better safety profile comparable to that of acyclovir. Constipation, headache, nausea and vomiting were the most commonly reported adverse effects, but constipation was considered to have a possible relationship to treatment. Conclusion:In conclusion, oral famciclovir administered three times daily for 7 days during acute zoster infection is as effective as acyclovir, administered 800mg five times daily.In addition it offers significant benefit by providing a well tolerated, cost effective, convenient dosage regime and accelerated rate of lesion resolution and a reduced duration of PHN.

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Once, twice, or three times daily famciclovir compared with aciclovir for the oral treatment of herpes zoster in immunocompetent adults: a randomized, multicenter, double-blind clinical trial

Cited by 68 publications

References 18 publications

A Comparative Study to Evaluate the Efficacy and Safety of Valacyclovir and Famcyclovir in the Management of Herpes Zoster in a Tertiary Care Hospital in Puducherry

A Comparative Study to Evaluate the Efficacy and Safety of Valacyclovir and Famcyclovir in the Management of Herpes Zoster in a Tertiary Care Hospital in Puducherry

Management of herpes zoster and postherpetic neuralgia

A Comparative Study to Evaluate the Efficacy and Safety of Acyclovir and Famciclovir in the Management of Herpes Zoster

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