Once-daily tasimelteon (VEC-162) for jet lag following transmeridian travel: A multicenter, randomized, double-blind, placebo-controlled trial

Polymeropoulos, Christos; Polymeropoulos, Vasilios M.; Czeisler, Emily; Fisher, Michaela; Smieszek, Sandra P.; Xiao, Changfu; Birznieks, Gunther; Polymeropoulos, Mihael H.

doi:10.3389/fneur.2022.901467

Front. Neurol.

2022

DOI: 10.3389/fneur.2022.901467

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Once-daily tasimelteon (VEC-162) for jet lag following transmeridian travel: A multicenter, randomized, double-blind, placebo-controlled trial

Christos Polymeropoulos

Vasilios M. Polymeropoulos

Emily Czeisler

et al.

Abstract: and Polymeropoulos MH ( ) Once-daily tasimelteon (VEC-) for jet lag following transmeridian travel: A multicenter, randomized, double-blind, placebo-controlled trial.

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Current perspective on circadian function of the kidney

Benjamin,

Pollock

2024

American Journal of Physiology-Renal Physiology

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Behavior and function of living systems are synchronized by the 24-hour rotation of the earth that guides physiology according to time of day. However, when behavior becomes misaligned from the light/dark cycle, such as in rotating shift work, jet lag, and even unusual eating patterns, adverse health consequences such as cardiovascular or cardiometabolic disease can arise. The discovery of cell autonomous molecular clocks expanded interest in regulatory systems that control circadian physiology including within the kidney where function varies along a 24-hour cycle. Our understanding of the mechanisms for circadian control of physiology is in the early stages and so the current review provides an overview of what is known and the many gaps in our current understanding. We include a particular focus on the impact of eating behaviors, especially meal timing. A better understanding of the mechanisms guiding circadian function of the kidney are expected to reveal new insights into causes and consequences of a wide range of disorders involving the kidney including hypertension, obesity, and chronic kidney disease.

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Current perspective on circadian function of the kidney

Benjamin,

Pollock

2024

American Journal of Physiology-Renal Physiology

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show abstract

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Once-daily tasimelteon (VEC-162) for jet lag following transmeridian travel: A multicenter, randomized, double-blind, placebo-controlled trial

Abstract: and Polymeropoulos MH ( ) Once-daily tasimelteon (VEC-) for jet lag following transmeridian travel: A multicenter, randomized, double-blind, placebo-controlled trial.

Cited by 1 publication

References 12 publications

Current perspective on circadian function of the kidney

Current perspective on circadian function of the kidney

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