Once Daily Intravenous Busulphan Plus Fludarabine As New Reduced Toxicity Myeloablative Conditioning for Acute Myeloid Leukemia and MDS Allogeneic Transplantation
Abstract:Background.
Allogeneic hemopoietic stem cell transplantation is the treatment of choice for high and intermediate risk acute myeloid leukemia (AML) and for higher risk myelodysplastic syndrome (MDS). Standards preparative regimens TBI-CY and BU-CY have been widely used and extra hematologic toxicity remains a concern. Even if the combination of intravenous formulation Busulphan-CY has shown lower toxicity and suggested favorable safety and efficacy profile new drugs associations are continuously… Show more
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