On X-Ray Diffraction Patterns from Liquids and Colloidal Gels

Clark, George L.; Aborn, R. H.; Brugmann, E. W.; Davidson, R. L.

doi:10.1073/pnas.13.7.549

Cited by 2 publications

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“…The fact that the XRD feature associated with breast cancer is a ring gives some clues as to its chemical nature. A circular feature (a “broad halo”) in an XRD pattern can be produced by an amorphous material such as oils 22. Thus, a possible explanation for the presence of the ring in the XRD patterns seen in the hair from breast cancer patients is an incorporation of lipid into the fibre.…”

Section: Introductionmentioning

confidence: 99%

“…A circular feature (a “broad halo”) in an XRD pattern can be produced by an amorphous material such as oils. 22 Thus, a possible explanation for the presence of the ring in the XRD patterns seen in the hair from breast cancer patients is an incorporation of lipid into the fibre. In this study we conducted a range of experiments to determine if the feature was related to lipids and if so, what is the nature of the lipids.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Breast Cancer-Associated Lipids in Scalp Hair

Mistry

Haklani²,

French

2012

Breast Cancer�(Auckl)

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A correlation between the presence of breast cancer and a change in the synchrotron-generated X-ray diffraction (XRD) pattern of hair has been reported in several publications by different groups, and on average XRD-based assays detect around 75% of breast cancer patients in blinded studies. To date, the molecular mechanisms leading to this alteration are largely unknown. We have determined that the alteration is likely to be due to the presence of one or more breast cancer-associated phospholipids. Further characterization of these lipids could be used to develop a novel, sensitive and specific screening test for breast cancer, based on hair initially, and potentially extendable to other biological samples.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%