On viral epidemics, zoonoses and memory

Wain‐Hobson, Simon; Meyerhans, Andreas

doi:10.1016/s0966-842x(99)01586-3

Cited by 2 publications

(2 citation statements)

References 24 publications

(19 reference statements)

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“…Given the similarity of the yeast cell wall components and their immunodominance [31,35,36], it seems likely that part of the measured CD8 responses are directed against cross-reactive epitopes. This would ¢t well with the promiscuous recognition potential of a TCR [37] and, from an evolutionary point of view, would help to maintain memory and mount a rapid immune response against a whole class of microorganisms [38]. At this stage, however, it is not possible to demonstrate cross-reactivity at the epitope level because neither the HLA class I-restricted immunogens, nor the primary Fig.…”

Section: Discussionmentioning

confidence: 99%

Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans

Heintel

Breinig

Meyerhans

2003

FEMS Immunology &Amp; Medical Microbiology

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The human cellular immune response against 14 distantly related yeast species was analyzed by intracellular cytokine staining of lymphocytes after ex vivo stimulation of whole blood. While the CD4 T cell response was marginal, extensive MHC class I-restricted CD8 T cell responses were detected against a number of species including spoiling, environmental and human pathogenic yeasts. The yeast-specific CD8 T cells expressed interferon-gamma but lacked expression of CD27 and CCR7, indicating that they were end-differentiated effector memory cells. Mainly intact yeast cells rather than spheroplasts were able to induce cytokine expression in T cells demonstrating that the dominant immunogens were located in the yeast cell wall. Together these data underline the importance of the cellular immune response in protecting humans against yeast and fungal infections. And, from another perspective, recombinant yeast suggests itself as a potential vaccine candidate to efficiently induce antigen-specific CD8 T cell responses.

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Section: Discussionmentioning

confidence: 99%

Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans

Heintel

Breinig

Meyerhans

2003

FEMS Immunology &Amp; Medical Microbiology

Self Cite

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“…Although many of today's doctors learned in their medical school textbooks that viruses were speciesspecific (Clough 2004), we now know interspecies navigation to be common. Creative "kingdom jumping" speculations of a plant reservoir for Ebola virus aside (Monath 1999), "novel" viruses, as obligate parasites, tend to come from other animal species almost by definition (Wain-Hobson and Meyerhans 1999).…”

Section: The Third Epidemiological Transition: Emerging Infectiousmentioning

confidence: 99%

The Human/Animal Interface: Emergence and Resurgence of Zoonotic Infectious Diseases

Greger

2007

Critical Reviews in Microbiology

224

171

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Emerging infectious diseases, most of which are considered zoonotic in origin, continue to exact a significant toll on society. The origins of major human infectious diseases are reviewed and the factors underlying disease emergence explored. Anthropogenic changes, largely in land use and agriculture, are implicated in the apparent increased frequency of emergence and re-emergence of zoonoses in recent decades. Special emphasis is placed on the pathogen with likely the greatest zoonotic potential, influenza virus A.

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On viral epidemics, zoonoses and memory

Cited by 2 publications

References 24 publications

Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans

Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans

The Human/Animal Interface: Emergence and Resurgence of Zoonotic Infectious Diseases

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