On using the linear-quadratic model in daily clinical practice

Definitive Radiation Therapy for Angiosarcoma of the Face and Scalp

“…Moreover, there is no clear evidence about effective radiation dose to control local disease. In previous reports, increased total radiation dose tended to have a favorable impact on local control (11). Several authors generally recommend approximately 50-70 Gy for treatment of AS-FS (2,14,17,18), whereas ore recent reports suggested that total doses of 70 Gy or more in conventional fractionations are effective in preventing local recurrence in patients with macroscopic disease (16,19,20).…”

“…To compare the effects of various treatment protocols with different fraction sizes and total doses, the biological effective dose (BED) was used in a linear-quadratic model (11). Here, the BED was defined as nd(1 + d/α/β), with gray units, where n is the fractionation number, d is the daily dose and α/β is assumed to be 10 for tumors.…”

Validation of the Total Dysphagia Risk Score (TDRS) as a predictive measure for acute swallowing dysfunction induced by chemoradiotherapy for head and neck cancers

“…The total dose of radiation therapy ranged from 50 -70 Gy, and the median dose was 70 Gy. As various treatment protocols with different fraction sizes and total doses had been used in our facility, we also calculated the biologically effective dose (BED) in a linear-quadratic model [4].…”

Computed tomography appearances of local recurrence after stereotactic body radiation therapy for stage I non-small-cell lung carcinoma

“…A total dose of 60 Gy in 10 fractions (two fractions daily for 5-8 days) at the minimum dose point in the PTV was delivered using a 6-MV X-ray. According to the linear-quadratic model, 11 the biologically effective dose (BED) at the isocenter was approximately 120 Gy.…”