On Track? Using the Human Genome Epidemiology Roadmap

Little, Julian; Hawken, Steven

doi:10.1159/000279627

Cited by 7 publications

(5 citation statements)

References 195 publications

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“…Technological advances in the fields of genomics, transcriptomics, proteomics and metabolomics [5,6] make it possible to further specify nutritional intake recommendations by tailoring them to individuals rather than subgroups of a population. A detailed overview of the technological advances and their applications is provided by García-Cañas et al [7].…”

Section: Introductionmentioning

confidence: 99%

Understanding Consumer Evaluations of Personalised Nutrition Services in Terms of the Privacy Calculus: A Qualitative Study

Berezowska¹,

Fischer²,

Ronteltap³

et al. 2014

Public Health Genomics

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Background: Personalised nutrition (PN) may provide major health benefits to consumers. A potential barrier to the uptake of PN is consumers' reluctance to disclose sensitive information upon which PN is based. This study adopts the privacy calculus to explore how PN service attributes contribute to consumers' privacy risk and personalisation benefit perceptions. Methods: Sixteen focus groups (n = 124) were held in 8 EU countries and discussed 9 PN services that differed in terms of personal information, communication channel, service provider, advice justification, scope, frequency, and customer lock-in. Transcripts were content analysed. Results: The personal information that underpinned PN contributed to both privacy risk perception and personalisation benefit perception. Disclosing information face-to-face mitigated the perception of privacy risk and amplified the perception of personalisation benefit. PN provided by a qualified expert and justified by scientific evidence increased participants' value perception. Enhancing convenience, offering regular face-to face support, and employing customer lock-in strategies were perceived as beneficial. Conclusion: This study suggests that to encourage consumer adoption, PN has to account for face-to-face communication, expert advice providers, support, a lifestyle-change focus, and customised offers. The results provide an initial insight into service attributes that influence consumer adoption of PN.

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Section: Introductionmentioning

confidence: 99%

Understanding Consumer Evaluations of Personalised Nutrition Services in Terms of the Privacy Calculus: A Qualitative Study

Berezowska¹,

Fischer²,

Ronteltap³

et al. 2014

Public Health Genomics

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“…It may also potentially provide patient-specific prescribing advice through decision support systems. Finally, genetic epidemiology is rising to new levels with the aggregation of genome-based data alongside public health and environmental registries (eg, such as cataloged in HuGENet19). Collectively, these sub-disciplines of bioinformatics have been suggested as core to the integration of biological and health data 20.…”

Section: Building On Previous Successesmentioning

confidence: 99%

Translational bioinformatics: linking knowledge across biological and clinical realms: Figure 1

Sarkar

Butte

Lussier

et al. 2011

J Am Med Inform Assoc

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Nearly a decade since the completion of the first draft of the human genome, the biomedical community is positioned to usher in a new era of scientific inquiry that links fundamental biological insights with clinical knowledge. Accordingly, holistic approaches are needed to develop and assess hypotheses that incorporate genotypic, phenotypic, and environmental knowledge. This perspective presents translational bioinformatics as a discipline that builds on the successes of bioinformatics and health informatics for the study of complex diseases. The early successes of translational bioinformatics are indicative of the potential to achieve the promise of the Human Genome Project for gaining deeper insights to the genetic underpinnings of disease and progress toward the development of a new generation of therapies.

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“…Before the GWAS era, the literature about the genetics of osteoporosis and fracture had been confined to a very large number of ''genome-wide linkage'' and ''candidate gene association'' studies. In retrospect, and with few exceptions, the majority were small, inadequately-powered studies generating controversial and frequently non-reproducible reports [3] on variants in about 150 candidate gene regions for osteoporosis according to HuGeNet [4]. Even though, a few polymorphisms were indeed identified as being associated with either BMD or fracture (such as for LRP5 [5] associated at P \ 5 9 10 -8 , the current standard for declaring genome-wide significance).…”

mentioning

confidence: 99%

Hunting osteoporosis susceptibility genes: bigger is better but diverse is also welcome

Rivadeneira

2012

Endocrine

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On Track? Using the Human Genome Epidemiology Roadmap

Cited by 7 publications

References 195 publications

Understanding Consumer Evaluations of Personalised Nutrition Services in Terms of the Privacy Calculus: A Qualitative Study

Understanding Consumer Evaluations of Personalised Nutrition Services in Terms of the Privacy Calculus: A Qualitative Study

Translational bioinformatics: linking knowledge across biological and clinical realms: Figure 1

Hunting osteoporosis susceptibility genes: bigger is better but diverse is also welcome

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