On the yolk sac of the cat

Tiedemann, K.

doi:10.1007/bf00219993

Cited by 15 publications

(3 citation statements)

References 26 publications

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“…It has been demonstrated that macrophages occur in the yolk sac of animal and human embryos. The F4/80 + primitive macrophages appear in murine yolk sac at E9, and then differentiate into fetal macrophages [36], [37], [42], [43], [44]. Fetal liver begins to form its fundamental structure at E10, and primitive macrophages are detected in the hepatic sinusoid [36].…”

Section: Discussionmentioning

confidence: 99%

CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver

Yang

Chen²,

Tsai³

et al. 2013

PLoS ONE

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CLEC4F, a member of C-type lectin, was first purified from rat liver extract with high binding affinity to fucose, galactose (Gal), N-acetylgalactosamine (GalNAc), and un-sialylated glucosphingolipids with GalNAc or Gal terminus. However, the biological functions of CLEC4F have not been elucidated. To address this question, we examined the expression and distribution of murine CLEC4F, determined its binding specificity by glycan array, and investigated its function using CLEC4F knockout (Clec4f−/−) mice. We found that CLEC4F is a heavily glycosylated membrane protein co-expressed with F4/80 on Kupffer cells. In contrast to F4/80, CLEC4F is detectable in fetal livers at embryonic day 11.5 (E11.5) but not in yolk sac, suggesting the expression of CLEC4F is induced as cells migrate from yolk cells to the liver. Even though CLEC4F is not detectable in tissues outside liver, both residential Kupffer cells and infiltrating mononuclear cells surrounding liver abscesses are CLEC4F-positive upon Listeria monocytogenes (L. monocytogenes) infection. While CLEC4F has strong binding to Gal and GalNAc, terminal fucosylation inhibits CLEC4F recognition to several glycans such as Fucosyl GM1, Globo H, Bb3∼4 and other fucosyl-glycans. Moreover, CLEC4F interacts with alpha-galactosylceramide (α-GalCer) in a calcium-dependent manner and participates in the presentation of α-GalCer to natural killer T (NKT) cells. This suggests that CLEC4F is a C-type lectin with diverse binding specificity expressed on residential Kupffer cells and infiltrating monocytes in the liver, and may play an important role to modulate glycolipids presentation on Kupffer cells.

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Section: Discussionmentioning

confidence: 99%

CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver

Yang

Chen²,

Tsai³

et al. 2013

PLoS ONE

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“…Rhesus monkey ES cells have also been reported to give rise to EryP [53]. Similar patterns of EryP development were observed in these different mammalian species including formation in the YS, circulation as large, nucleated cells, loss of the nucleoli, and condensation of the nucleus [36, 172]. …”

Section: Primitive Erythropoiesis In Other Vertebratesmentioning

confidence: 88%

“…EryP have been observed in embryos from a number of different species including mouse, Syrian hamster [36, 140], Mongolian gerbil [171], rabbit, cat [172], merino sheep [173], pig, cow, and human (described in [132]). Rhesus monkey ES cells have also been reported to give rise to EryP [53].…”

Section: Primitive Erythropoiesis In Other Vertebratesmentioning

confidence: 99%

The Modern Primitives: Applying New Technological Approaches to Explore the Biology of the Earliest Red Blood Cells

Fraser

2013

ISRN Hematology

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One of the most critical stages in mammalian embryogenesis is the independent production of the embryo's own circulating, functional red blood cells. Correspondingly, erythrocytes are the first cell type to become functionally mature during embryogenesis. Failure to achieve this invariably leads to in utero lethality. The recent application of technologies such as transcriptome analysis, flow cytometry, mutant embryo analysis, and transgenic fluorescent gene expression reporter systems has shed new light on the distinct erythroid lineages that arise early in development. Here, I will describe the similarities and differences between the distinct erythroid populations that must form for the embryo to survive. While much of the focus of this review will be the poorly understood primitive erythroid lineage, a discussion of other erythroid and hematopoietic lineages, as well as the cell types making up the different niches that give rise to these lineages, is essential for presenting an appropriate developmental context of these cells.

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Ultrastructure of the placenta and fetal membranes of the dog: II. The yolk sac

et al. 1983

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Yolk sacs from dogs at 40, 50, and 60 days of gestation were examined by electron microscopy. Free ribosomes, mitochondria, and rough endoplasmic reticulum (rER) are more prominent in both endoderm and mesothelium at 40 and 50 days than at 60 days, suggesting a greater synthetic capacity at the earlier stages. Smooth endoplasmic reticulum (sER) and glycogen are also present in greater amounts in the endoderm in the earlier stages. In the mesothelium, however, low amounts of sER and glycogen are consistently present. Certain possibilities relative to the nature of the synthetic activities in these two tissues are discussed. Large amounts of smooth-surfaced vesicles were observed along the basal edges of the 60-day mesothelium; they are indicative of transport processes occurring at this time. As gestation proceeds, in both endoderm and mesothelium, the Golgi complex remains well developed, there are more numerous lysosomelike bodies, and bundles of intermediate filaments either increase or become more diffused. In some endoderm cells at 60 days, large vacuoles and dense glycogen deposits were noted. These observations indicate that degenerative processes are gradually occurring in the endoderm and mesothelium as parturition draws near. Erythropoiesis occurs in the mesenchyme at 40 and 50 days. At 40 days also, segments of endothelium were seen within blood islands, indicating that the endothelial lining of some yolk sac vessels differentiates from cells located in the interior of such islands.

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On the yolk sac of the cat

Cited by 15 publications

References 26 publications

CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver

CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver

The Modern Primitives: Applying New Technological Approaches to Explore the Biology of the Earliest Red Blood Cells

Ultrastructure of the placenta and fetal membranes of the dog: II. The yolk sac

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