On the wetting properties of human <i>stratum corneum epidermidis</i> surface exposed to cold atmospheric-pressure pulsed plasma

Athanasopoulos, D.; Svarnas, P.; Ladas, S.; Kennou, S.; Koutsoukos, P. G.

doi:10.1063/1.5027901

Cited by 27 publications

(17 citation statements)

References 65 publications

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“…Recently, improved wettability of the stratum corneum after cold atmospheric plasma treatment has been proposed as an additional effect to facilitate drug delivery through the skin [24,25]. While we have not quantitatively studied the water contact angle in our experiments, in accordance with these studies we have qualitatively observed a substantially improved spreading of water droplets after plasma treatments of skin as well.…”

Section: Resultssupporting

confidence: 77%

Plasma Permeabilization of Human Excised Full-Thickness Skin by µs- and ns-pulsed DBD

Gelker¹,

Müller‐Goymann²,

Viöl³

2020

Skin Pharmacol Physiol

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Introduction: Cold atmospheric plasma (CAP) is gaining increasing importance as a medical or cosmetic treatment for various indications. The technology is best suited to the treatment of surfaces such as the skin and is already used in wound care and, in exemplary case studies, the reduction of superficial tumors. Several plasma sources have been reported to affect the skin barrier function and potentially enable drug delivery across or into plasma-treated skin. Objective: In this study, this effect was quantified for different plasma sources in order to elucidate the influence of voltage rise time, pulse duration, and power density in treatments of fullthickness skin. Methods: We compared three different dielectric barrier discharges (DBDs) as to their permeabilization efficiency using Franz diffusion cell permeation experiments and measurements of the transepithelial electrical resistance (TEER) with full-thickness human excised skin. Results: We found a significant reduction of the TEER for all three plasma sources. Permeation of the hydrophilic sodium fluorescein molecule was enhanced by a factor of 11.7 (low power) to 41.6 (high power) through µs-pulsed DBD-treated skin. A smaller effect was observed after treatment with the ns-pulsed DBD. Conclusions: The direct treatment of excised human full-thickness skin with CAP, specifically a DBD, can lead to pore formation and enhances transdermal transport of sodium fluorescein.

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Section: Resultssupporting

confidence: 77%

Plasma Permeabilization of Human Excised Full-Thickness Skin by µs- and ns-pulsed DBD

Gelker¹,

Müller‐Goymann²,

Viöl³

2020

Skin Pharmacol Physiol

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“…The specifications of the plasma-jet reactor employed here for the bacterium treatment and the involved physics for the same [29][30][31] or similar [4,5,12,32,72,73] coaxial DBD-based systems have been discussed in these previous reports of our group. The present operational window (see below) is selected as an effective one, based on those previous studies.…”

Section: Plasma Setupmentioning

confidence: 99%

“…Figure 2 presents a typical pair of the driving voltage and the generated DBD current waveforms, as they are recorded by means of a wideband high voltage divider (Tektronix P6015; DC-75 MHz, Beaverton, OR, USA) and wideband current monitor (Pearson Electronics 6585; 40 Hz-200 MHz, Palo Alto, CA, USA), respectively, on a digital oscilloscope (LeCroy WaveRunner 44Xi-A; 400 MHz; 5 GSamples s −1, Chestnut Ridge, NY, USA). Emissive species and gas temperature are identified by UV-visible, high resolution OES, as described in references [4,[29][30][31][32]. In particular, the gas temperature is evaluated by comparing experimentally-determined rotational distributions of probe molecules with the corresponding theoretical ones calculated with a software developed previously [74].…”

Section: Plasma Setupmentioning

confidence: 99%

“…Parkey Unlike to the abovementioned excellent works, herein a coaxial DBD-based helium plasma micro-jet is evaluated against A. baumannii deactivation. This setup has been previously used for liposome [29,30] and human skin [31] treatment, under various conditions. Thus, here colony counting and scanning electron microscopy (SEM) provide insights into the plasma-induced damage of A. baumannii and it is shown that post-treatment (delayed) effects are dominant.…”

Section: Introductionmentioning

confidence: 99%

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Acinetobacter baumannii Deactivation by Means of DBD-Based Helium Plasma Jet

Svarnas

Spiliopoulou

Koutsoukos

et al. 2019

Plasma

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Acinetobacter baumannii is a typically short, almost round, rod-shaped (coccobacillus) Gram-negative bacterium. It can be an opportunistic pathogen in humans, affecting people with compromised immune systems, and it is becoming increasingly important as a hospital-associated (nosocomial) infection. It has also been isolated from environmental soil and water samples. In this work, unlike conventional medical methods like antibiotics, the influence of atmospheric-pressure cold plasma on this bacterium is evaluated by means of a colony count technique and scanning electron microscopy. The plasma used here refers to streamers axially propagating into a helium channel penetrating the atmospheric air. The plasma is probed with high resolution optical emission spectroscopy and copious reactive species are unveiled under low-temperature conditions. Based on the experimental results, post-treatment (delayed) biochemical effects on Acinetobacter baumannii and morphological modifications appear dominant, leading to complete deactivation of this bacterium.

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“…Cold Atmospheric Pressure Plasma jets (CAPP jets) are a hot research topic due their potentiality in many biomedical applications 1 . Indicatively, we refer sterilization 2 , treatment of tissues 3 and liposomes 4,5 , as well as cells including cancer treatment 6 . The study of CAPP jets is based on experiments that aim to characterize the plasma by providing information on the ionic species, the properties of the plasma plume, its temperature, etc.…”

mentioning

confidence: 99%

Modelling the electric field in reactors yielding cold atmospheric–pressure plasma jets

Vafeas

Papadopoulos

Vafakos

et al. 2020

Sci Rep

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The behavior of the electric field in Cold Atmospheric–Pressure Plasma jets (CAPP jets) is important in many applications related to fundamental science and engineering, since it provides crucial information related to the characteristics of plasma. To this end, this study is focused on the analytic computation of the electric field in a standard plasma reactor system (in the absence of any space charge), considering the two principal configurations of either one–electrode or two–electrodes around a dielectric tube. The latter is considered of minor contribution to the field calculation that embodies the working gas, being an assumption for the current research. Our analytical technique employs the cylindrical geometry, properly adjusted to the plasma jet system, whereas handy subdomains separate the area of electric activity. Henceforth, we adapt the classical Maxwell’s potential theory for the calculation of the electric field, wherein standard Laplace’s equations are solved, supplemented by the appropriate boundary conditions and the limiting conduct at the exit of the nozzle. The theoretical approach matches the expected physics and captures the corresponding essential features in a fully three–dimensional fashion via the derivation of closed–form expressions for the related electrostatic fields as infinite series expansions of cylindrical harmonic eigenfunctions. The feasibility of our method for both cases of the described experimental setup is eventually demonstrated by efficiently incorporating the necessary numerical implementation of the obtained formulae. The analytical model is benchmarked against reported numerical results, whereas discrepancies are commented and prospective work is discussed.

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On the wetting properties of human stratum corneum epidermidis surface exposed to cold atmospheric-pressure pulsed plasma

Cited by 27 publications

References 65 publications

Plasma Permeabilization of Human Excised Full-Thickness Skin by µs- and ns-pulsed DBD

Plasma Permeabilization of Human Excised Full-Thickness Skin by µs- and ns-pulsed DBD

Acinetobacter baumannii Deactivation by Means of DBD-Based Helium Plasma Jet

Modelling the electric field in reactors yielding cold atmospheric–pressure plasma jets

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