On the Way to Nanometer‐Sized Information of the Bacterial Surface by Tip‐Enhanced Raman Spectroscopy

Neugebauer, Ute; Rösch, Petra; Schmitt, Michael; Popp, Jürgen; Julien, C.; Rasmussen, Akiko; Budich, Christian; Deckert, Volker

doi:10.1002/cphc.200600173

Cited by 185 publications

(149 citation statements)

References 23 publications

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“…Neugebauer et al measured TERS spectra from Staphylococcus epidermidis [370,371], while Cialla et al measured TERS spectra from tobacco mosaic viruses [372]. Other bacteria-derived samples, such as isolated membrane patches from Halobacterium salinarum have also been measured with TERS, with different patches able to be distinguished [373].…”

Section: Applicationsmentioning

confidence: 99%

Raman spectroscopy: techniques and applications in the life sciences

Shipp¹,

Sinjab²,

Notingher³

2017

Adv. Opt. Photon.

254

189

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Raman spectroscopy is an increasingly popular technique in many areas including biology and medicine.It is based on Raman scattering, a phenomenon in which incident photons lose or gain energy via interactions with vibrating molecules in a sample. These energy shifts can be used to obtain information regarding molecular composition of the sample with very high accuracy. Applications of Raman spectroscopy in the life sciences have included quantification of biomolecules, hyperspectral molecular imaging of cells and tissue, medical diagnosis, and others. This review briefly presents the physical origin of Raman scattering explaining the key classical and quantum mechanical concepts. Variations of the Raman effect will also be considered, including resonance, coherent, and enhanced Raman scattering. We discuss the molecular origins of prominent bands often found in the Raman spectra of biological samples. Finally, we examine several variations of Raman spectroscopy techniques in practice, looking at their applications, strengths, and challenges. This review is intended to be a starting resource for scientists new to Raman spectroscopy, providing theoretical background and practical examples as the foundation for further study and exploration.

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Section: Applicationsmentioning

confidence: 99%

Raman spectroscopy: techniques and applications in the life sciences

Shipp¹,

Sinjab²,

Notingher³

2017

Adv. Opt. Photon.

254

189

View full text Add to dashboard Cite

show abstract

“…The applications range from small biomolecules, such as adenine, [25,26] over the biopolymers alginate, [27,28] cytochrome c, [29] and RNA, [30] to living bacterial cells. [31,32] However, all these TERS measurements have been performed in air. Even bacterial cells have been investigated in air.…”

Section: Introductionmentioning

confidence: 99%

Performing tip‐enhanced Raman spectroscopy in liquids

Schmid

Yeo

Leong

et al. 2009

J Raman Spectroscopy

160

181

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“…Since the first reports in 2000, [1,4,5] TERS has been successfully implemented in different disciplines, such as life science, [6,7] material science, [8] surface science, [9] etc. Besides these applications, TERS has also been used to study some of the most fundamental aspects of its cousin technique, surface-enhanced Raman spectroscopy (SERS), especially the properties of the 'hot' spot in SERS, since TERS is playing with a single 'hot' spot and can collect both the topographic information and the Raman spectrum simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Local field enhancement of an infinite conical metal tip illuminated by a focused beam

Zhang

Cui

Martin

2009

J Raman Spectroscopy

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We present a systematic numerical investigation of conical metal tips which are commonly used in tip-enhanced Raman spectroscopy (TERS). Different from previous studies, we focus on how the tip length and the illumination condition influence the local field enhancement at the tip apex, and provide a useful reference for real experiments. In particular, we show that the type of illumination has a dramatic influence on the field enhancement: a localized illumination spot -as used in experiments -producing a very different response than a plane wave illumination -as usually used in previous models. Also, the effect of the different geometrical parameters, such as the sharpness of the tip apex and the cone angle, provides guidance to optimize the tip design. Finally, we investigate the influence of the substrate and compare numerical data with results deduced from a simplified model, finding good agreement. This brings new insights into the enhancement mechanism of TERS.

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On the Way to Nanometer‐Sized Information of the Bacterial Surface by Tip‐Enhanced Raman Spectroscopy

Cited by 185 publications

References 23 publications

Raman spectroscopy: techniques and applications in the life sciences

Raman spectroscopy: techniques and applications in the life sciences

Performing tip‐enhanced Raman spectroscopy in liquids

Local field enhancement of an infinite conical metal tip illuminated by a focused beam

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