1944
DOI: 10.1126/science.100.2585.36
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On the Vitamin B c Conjugate in Yeast

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Cited by 73 publications
(10 citation statements)
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“…As discussed earlier (Section II.A), both folic and folinic acid havebeen isolated from natural sources as polyglutamyl conjugates (36)(37)(38)(39)(117)(118)(119)(120)(121)(122)(159)(160)(161)(162)(163)(164). The existence in tissues of the unconjugated forms is difficult to establish unequivocally owing to possible degradation of the conjugates.…”
Section: Isolation Identification and Natural Occurrence Of Fotjmentioning
confidence: 99%
“…As discussed earlier (Section II.A), both folic and folinic acid havebeen isolated from natural sources as polyglutamyl conjugates (36)(37)(38)(39)(117)(118)(119)(120)(121)(122)(159)(160)(161)(162)(163)(164). The existence in tissues of the unconjugated forms is difficult to establish unequivocally owing to possible degradation of the conjugates.…”
Section: Isolation Identification and Natural Occurrence Of Fotjmentioning
confidence: 99%
“…The association of anemia in chicks with deficiency of dietary substances found in liver, spinach, and yeast was subsequently recognized to represent, in actuality, folic acid (pteroylglutamic acid) deficiency (20)(21)(22)(23). Granulocytopenia in rats on purified diets was found to be correctible by administering folic acid (24).…”
Section: Folic Acid Antagonistsmentioning
confidence: 99%
“…Some yeast extracts curative in the macrocytic anemia of chicks and monkeys would not support the growth of L. casei [20]. Thus, it appeared that the chick anemia assay and the L. casei assay were not measuring the same principle.…”
Section: Introductionmentioning
confidence: 99%