On the Vitamin B
            <sub>c</sub>
            Conjugate in Yeast

Binkley, S. B.; Bird, O. D.; Bloom, Evelyn; Brown, Roy C.; Calkins, D. G.; Campbell, Callum J.; Emmett, A. D.; Pfiffner, J. J.

doi:10.1126/science.100.2585.36

Cited by 73 publications

(10 citation statements)

References 12 publications

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“…As discussed earlier (Section II.A), both folic and folinic acid havebeen isolated from natural sources as polyglutamyl conjugates (36)(37)(38)(39)(117)(118)(119)(120)(121)(122)(159)(160)(161)(162)(163)(164). The existence in tissues of the unconjugated forms is difficult to establish unequivocally owing to possible degradation of the conjugates.…”

Section: Isolation Identification and Natural Occurrence Of Fotjmentioning

confidence: 99%

Folic Acid Coenzymes and One‐Carbon Metabolism

Huennekens

Osborn

1959

Advances in Enzymology - And Related Areas of Molecular Biology

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Section: Isolation Identification and Natural Occurrence Of Fotjmentioning

confidence: 99%

Folic Acid Coenzymes and One‐Carbon Metabolism

Huennekens

Osborn

1959

Advances in Enzymology - And Related Areas of Molecular Biology

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“…The association of anemia in chicks with deficiency of dietary substances found in liver, spinach, and yeast was subsequently recognized to represent, in actuality, folic acid (pteroylglutamic acid) deficiency (20)(21)(22)(23). Granulocytopenia in rats on purified diets was found to be correctible by administering folic acid (24).…”

Section: Folic Acid Antagonistsmentioning

confidence: 99%

The Chemical Control of Cancer: PHR Review

Holland¹

1954

Public Health Reports (1896-1970)

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“…Some yeast extracts curative in the macrocytic anemia of chicks and monkeys would not support the growth of L. casei [20]. Thus, it appeared that the chick anemia assay and the L. casei assay were not measuring the same principle.…”

Section: Introductionmentioning

confidence: 99%

A History of the Isolation and Identification of Folic Acid (Folate)

Rosenberg¹

2012

Ann Nutr Metab

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In the 1930s, Lucy Wills identified a ‘new hemopoietic factor’ in yeast and liver which cured tropical macrocytic anemia in humans and experimental anemia in monkeys. Janet Watson and William B. Castle named the unknown substance, which would ultimately become a form of folate, ‘Wills’ factor’. Further studies with this unknown substance showed that it was active against nutritional pancytopenia in monkeys and experimental anemia in chicks, leading to various designations such as vitamin M (monkey) and vitamin B_c (chick). Other factors with growth-promoting activity for microorganisms such as Lactobacillus casei were given the interim names including folic acid – in recognition of extracts from leafy greens. Competing pharmaceutical research groups headed by Robert Stokstad at Lederle Laboratories and Joseph John Pfiffner at Parke-Davis Research Laboratory independently isolated factors bearing the biological properties of Wills’ factor and other unknown related factors including folic acid, Lederle Laboratories from a bacterial culture and Parke-Davis Laboratory from yeast and liver as a conjugate of folate. The new vitamin then was crystallized, chemically identified, and synthesized as pteroylglutamic acid and named folic acid between 1943 and 1945. Further studies of the monoglutamic folic acid and the yeast isolate polyglutamyl folate followed through the 1950s and to the present.

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On the Vitamin B _c Conjugate in Yeast

Cited by 73 publications

References 12 publications

Folic Acid Coenzymes and One‐Carbon Metabolism

Folic Acid Coenzymes and One‐Carbon Metabolism

The Chemical Control of Cancer: PHR Review

A History of the Isolation and Identification of Folic Acid (Folate)

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On the Vitamin B c Conjugate in Yeast

Cited by 73 publications

References 12 publications

Folic Acid Coenzymes and One‐Carbon Metabolism

Folic Acid Coenzymes and One‐Carbon Metabolism

The Chemical Control of Cancer: PHR Review

A History of the Isolation and Identification of Folic Acid (Folate)

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Product

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On the Vitamin B _c Conjugate in Yeast