On the value of P300 Event-Related Potentials in the Differential Diagnosis of Dementia

Slaets, Joris P. J.; Fortgens, C.

doi:10.1192/bjp.145.6.652

Cited by 52 publications

(11 citation statements)

References 32 publications

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“…[52], Yamashita et al [72], Squires et al [73], Ito [74] and Syndulko et al [75] found a laten cy prolongation of the auditory P300 (P3b) between 1.8 and 1.1 ms/year (table 1), where as Pfefferbaum et al [76], Hegerl et al [77] and Slaets and Fortgens [78] reported about an age-related increase in the P300 latency between 0.94 and 0.30 ms/year. Apart from the study of Slaets and Fortgens [78], which yielded P300 potentials in only about 30% of the normal controls and should therefore be considered with caution, these differences in the amount of the age-associated prolonga tions of the P300 latencies are relatively small.…”

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confidence: 95%

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The Event-Related P300 Potential Analysis of Cognitive Human Brain Aging: A Review

1993

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Event-related P300 potentials are closely reflecting cognitive functions such as stimulus evaluation time (P300 latency) and task relevance (P300 amplitude). Hence, both their potential clinical application for detecting slight cognitive disturbances and an increasing interest in the aging of cognitive human brain functions resulted in a growing number of studies on age-related P300 changes. Although there are converging lines of evidence that aging results in prolongations of P300 latencies, reductions of P300 amplitudes and a more equipotential P300 scalp distribution, the amount of these changes and the best fit for the P300-age interactions, respectively, remain still controversial. In general, these P300 alterations obviously reflect only minor cognitive changes during normal aging. For their clinical application, however, it is necessary to obtain an age-matched normative database. Furthermore, the increased P300 variability in the elderly has to be reduced – as far as possible – by appropriate simple P300 paradigms which should be preferentially applied in longitudinal analyses to differentiate normal from pathological aging of cognitive functions. Finally, additional cross-correlational analyses between the P300 and morphological as well as neurobiochemical data are needed. By these means, our knowledge about age-related changes of cognitive brain functions should be considerably enlarged.

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confidence: 95%

“…Apart from the study of Slaets and Fortgens [78], which yielded P300 potentials in only about 30% of the normal controls and should therefore be considered with caution, these differences in the amount of the age-associated prolonga tions of the P300 latencies are relatively small. This holds also true even for different kinds of P300 potentials.…”

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confidence: 99%

The Event-Related P300 Potential Analysis of Cognitive Human Brain Aging: A Review

1993

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“…21 P 300 latency is an index of cognitive processing time and was shown to be prolonged in normal aging, confusional states, and dementia. [22][23][24] P 300 latency has been found also to be a sensitive marker of subclinical encephalopathy in hepatic and renal failure. [25][26][27][28] The effect of acute hypoxia on EREP was studied in an experiment that utilized a simulated high altitude environment, and P 300 latency was found to be delayed.…”

Section: Dovepressmentioning

confidence: 99%

Event-related evoked potentials in chronic respiratory encephalopathy

Tahan

Zaidan²,

Jones³

et al. 2010

COPD

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Background:Cognitive event-related potential (P 300 ) is an index of cognitive processing time. It was found to be prolonged in dementia, renal, and hepatic encephalopathies, but was not extensively assessed in respiratory failure. Objective: To evaluate P 300 changes in patients with respiratory failure, and especially those with mild or subclinical hypoxic-hypercapnic encephalopathy. Methods: Auditory event-related evoked potential P 300 latency was measured using an oddball paradigm in patients with respiratory failure due to any cause (partial pressure of oxygen in arterial blood (PO 2 ) should be 75 mm/Hg or less). Apart from blood gases measurement, patients underwent the Mini-Mental State Examination (MMSE). Patient performances were compared with that of matched normal control. Patients were admitted into the study from outpatient clinics and wards at King Khalid University Hospital and Sahara Hospital. Results: Thirty-four patients (12 women, 22 men) were admitted to the study. Ages ranged from 19-67 years with a mean of 46.1 years. Respiratory failure was severe or very severe in 11 patients (33%), and mild or moderate in the rest (66%). Mean value for PO 2 and partial pressure of carbon dioxide in arterial blood (PCO 2 ) were 63.7 and 45.2 mm/Hg, respectively. pH mean was 7.4 and O 2 saturation was 90.7%. P 300 latency ranged from 218 to 393 milliseconds, with a mean of 338.4 milliseconds. In comparison with control (309.9 milliseconds), there was a significant difference (P = 0.007). P 300 amplitude differences were not significant. No significant difference in MMSE was noted between mild and severe respiratory failure. Results of detailed neuropsychological assessment were clearly abnormal but were limited by the small number of tested patients. P 300 latency changes correlated significantly with age as well as severity of respiratory failure. P 300 was also significantly delayed whether hypoxia occurred with or without hypercapnia. Conclusion: Results show a significant delay of P 300 latency in patients with severe and mild respiratory failure. This was associated with subclinical encephalopathy in most patients, evidenced by a near-normal MMSE score. Apart from confirming the importance of P 300 latency measurement as a marker of respiratory encephalopathy, this study asserts the causal relationship between hypoxemia and cognitive derangement. Furthermore, it promotes the early use of oxygen therapy in a selected group of patients with mild or moderate respiratory failure, who have responsibilities which involve taking rapid critical decisions.

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“…Die Einbeziehung evozierter Potentiale und hier im besonderen der Latenz der P300 zur Diagnose von Demenzen hat in den letzten Jahren erhebliche Fortschritte gcbracht (2, 10,12,14,17,19). Viele diesbezügliche Untersuchungen mit Analyse von evozierten Potentialen und Reaktionszcitmessungen zeigen signifikante Gruppeneffekte hinsichtlich einer P300 Latenz-und Reaktionszeitverlängening dementer Patienten gegenüber gesunden Kontrollpersonen.…”

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P300 und Demenz: Diagnostische Relevanz I

Wranek¹,

Ladurner²,

Klimesch³

1990

Klin Neurophysiol

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P300 and Dementia: A critical evaluation of its diaenostical relevante I Visual evoked potentials, including the P300 response, and reactiontime were recorded from 20 patients with multiinfarct dementia, 20 nondemented patients with brain-infarct diseases, and 20 age-matched control subjects. Additionally the patients were assessed using thc WAISindex.Prolonged P300 latency and rcactiontime occured in both of thc paticnt-groups, correlatcd significantly with the WAIS-index. Howevcr, effects regarding to P300 latency and reactiontimc wcrc not strong enough to allow individual classifications.

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On the value of P300 Event-Related Potentials in the Differential Diagnosis of Dementia

Cited by 52 publications

References 32 publications

The Event-Related P300 Potential Analysis of Cognitive Human Brain Aging: A Review

The Event-Related P300 Potential Analysis of Cognitive Human Brain Aging: A Review

Event-related evoked potentials in chronic respiratory encephalopathy

P300 und Demenz: Diagnostische Relevanz I

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