On the usefulness of point-of-care antibody tests for SARS-CoV-2 in community screening settings

Döhla, Manuel; Diegmann, Christin

doi:10.1016/j.puhe.2020.05.031

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Detecting the specifi c anti-SARS-CoV2 antibodies could effectively and quickly identify the COVID-19 patients [11][12][13]. Antibody testing has been incorporated into COVID- shtml).…”

Section: Introductionmentioning

confidence: 99%

The analysis of characteristics of anti-SARS-CoV-2 antibodies in clinically COVID-19 patients

Guo¹,

Yu²,

Li³

et al. 2020

J Clin Res Ophthalmol

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Background: The novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had spread all of China and many other countries. The COVID-19 patients exhibit typical clinical symptoms, and most cases could be diagnosed by nucleic acid testing and imaging. Recent studies have reported that serum antibody testing can be used for diagnostic screening of SARS-CoV-2 infection. However, the rules and standards of antibody production in serum of discharged COVID-19 patients remain ambiguous. Methods: We examined both nucleic acid and antibody detection of 139 non-severe (mild and common) patients who were diagnosed with COVID-19. Results: Although the nucleic acid of the discharged patient has turned to negative, some patients have not detected antibodies, including IgG (n=11) and IgM (n=27) .19.4% (27/139) discharged patients' IgM detection was negative. In the IgM positive discharged patients, 72.8% (83/114) have an onset time over 30 days. And, there was no statistically signifi cant difference in IgM concentration of discharged patients from 4 to 9 weeks after the onset of disease. In addition, we also detected IgM and IgG in nucleic acid test positive patients (n=12) within two weeks after the onset of disease. The concentration of IgM was peaked about on the sixth day and then decreased, while the IgG concentration was continuously increasing. Conclusions: Our study demonstrated the rules and standards of antibody production in serum of discharged COVID-19 patients which will provide more ideas for COVID-19 research.

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“…Detecting the specifi c anti-SARS-CoV2 antibodies could effectively and quickly identify the COVID-19 patients [11][12][13]. Antibody testing has been incorporated into COVID- shtml).…”

Section: Introductionmentioning

confidence: 99%