On the Use of Thyroid Extract in Puerperal Eclampsia and in the Preeclamptic State.

Nicholson, H. Oliphant

doi:10.1111/j.1471-0528.1902.tb14999.x

Cited by 2 publications

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Section: Discussionmentioning

confidence: 99%

“…Early in the 20th century, use of large doses of thyroid extract was one of the interventions for the management and prevention of eclampsia [21]. However, the probable mode of action as well as the pathophysiology of preeclampsia and eclampsia was still elusive [21]. Given that the thyroid gland has iodine stores as well as T3 and T4 hormones, it was not stated which one or a combination of these compounds was of therapeutic value.…”

Section: Discussionmentioning

confidence: 99%

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Low serum triiodothyronine and potassium levels are associated with increased risk of eclampsia among women in the Eastern Cape Province of South Africa

Businge¹,

Longo-Mbenza²,

Kengne³

2022

Clin. Exp. Obstet. Gynecol.

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Background:There is paucity of data on the relationship between thyroid hormones, potassium and eclampsia. Moderate-to-severe iodine deficiency that worsens during pregnancy leads to decreased thyroid hormone output and bioavailability to the brain. Apart from metabolic functions, T3 and T4 are essential fast acting cytosolic and synaptosomal neural transmitters that also regulate neuronal excitatory-inhibitory mechanisms. T3 also regulates the Na + -K + -ATPase pump that maintains the membrane ionic gradient. Hence altered serum potassium, thyroxine and triiodothyronine levels could increase the risk of eclamptic seizures. Methods: Forty-five women with eclampsia, 45 severe preeclampsia and 90 normotensive pregnant controls were enrolled into this study. Levels of thyroid hormones, thyroglobulin and urine iodine concentration (UIC) were measured and compared between the three groups. Results: Eclamptic participants had significantly lower median serum potassium (K), triiodothyronine (FT3), urinary iodine concentration (UIC) but higher serum thyroglobulin (Tg) (K = 3.7 mmol/L; FT3 = 3.8 pmol/L; UIC = 69.5 µg/L; Tg = 39.0 µg/L) than normotensive pregnant controls (K = 4.3 mmol/L; T3 = 4.7 pmol/L; UIC = 169.5 µg/L; Tg = 19.5 µg/L) and participants with severe preeclampsia (K = 4.2 mmol/L; T3 = 4.4 pmol/L; UIC = 95.7 µg/L; Tg = 22.4 µg/L), p < 0.05. Low UIC, low serum T3 and potassium and elevated Tg were independent predictors of eclampsia. Conclusions: Women with iodine deficiency in pregnancy may be at increased risk of eclampsia secondary to the ensuing rapid peripheral turnover of thyroid hormones leading to hypothyroxinaemia and reduced triiodothyronine bioavailability to the central nervous system that can be exacerbated by hypokalaemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%