On the use of monocrystalline antimony pH electrodes in gastro-oesophageal functional disorders

Ask, Per; Edwall, G.; Johansson, Karl‐Erik; Tibbling, Lita

doi:10.1007/bf02442809

Cited by 41 publications

(21 citation statements)

References 16 publications

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“…Therefore, the pH, values sampled from each measuring area may be as sumed to represent local variations. The electrochemical reactions generating the antimony electrode potential have not yet been fully elucidated but they arc generally assumed to depend on two reactions [22], One is the anti mony dissolution reaction, and the other the oxygen reduction reaction. pH sensitivity evaluation of COMA at very low oxygen partial pressures has not been performed previously, but it has been presumed that the characteris tics of the antimony electrode would deteriorate at low oxygen partial pressures [23].…”

Section: Coma Electrodementioning

confidence: 99%

pH Heterogeneity in Skeletal Muscle Extracellular Fluid

1996

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Oxygen and carbon dioxide are known to be heterogeneously distributed in tissues. Extracellular skeletal muscle tissue pH (pH_t) also exhibits a spatial variability in vitro, but this has not been examined in vivo. pH_t distributions in resting skeletal muscle and the effect of the dispersion of pH_t on ischemia and normoxic hypercarbia was therefore studied in an animal model with a multichannel pH microelectrode. Under resting conditions and spontaneous breathing, local pH_t (from all animals, n = 10) was found to vary between 6.96 and 7.68 (range), and 70% of the values were within a pH of 7.00-7.32. In each animal the maximum pH_t differences (maximum range between the 6 channels of the microelectrode) found were 0.32 ± 0.11 pH units (mean ± SD). During tissue acidosis, induced by ischemia, no significant change in the local pH_t differences in each animal was seen. During normoxic hypercarbia a 2-fold increase in pH_t variability within each animal was noticed (p < 0.01), which suggests that carbon dioxide and buffering effects of the blood are significant factors for the pH_t distribution. The pH_t distribution range found is of similar magnitude as previously described in in vitro studies on skeletal muscle. Locally varying pH_t levels may be of importance as they will affect cellular H⁺ extrusion, membrane potential and volume control of different cell populations differently.

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Section: Coma Electrodementioning

confidence: 99%

pH Heterogeneity in Skeletal Muscle Extracellular Fluid

1996

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“…monocrystalline anti mony electrodes introduced by Edwall [ 10] and Ask et al [11] (0011, Synectics Medical AB. Stockholm, Sweden) with an external reference electrode (Ag/ AgCl) attached to the chest were used.…”

Section: Methodsmentioning

confidence: 99%

Standardization of Electrode Positioning and Composition of Meals for Long-Term Intragastric pH Metry in Man

Londong

Angerer²,

Bosch³

et al. 1990

Dig Dis

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In these prospective studies the influence of two different intragastric positions of electrodes and of four different compositions of standardized meals on 24-hour ambulatory pH recording were compared intraindividually in healthy male subjects. Simultaneous pH monitoring in 12 subjects demonstrated a more pronounced postprandial pH elevation in the fundus body compared to the antral area. The intraindividual comparison of an identical diet given on two different days to 10 subjects revealed nearly identical pH profiles. Variations of carbohydrate, protein and fat content of isocaloric meals given in a randomized order did not significantly alter 24-hour intragastric pH profiles. It is concluded from these data that positioning of the pH electrode in the fundus body area is superior to an antral position. 24-hour ambulatory intragastric pH monitoring in man is well reproducible. A strict standardization of the composition of meals is mandatory only for scientific investigations.

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“…E -E » -(R T /z F )-ln 10-pH (2) and, when the constants are replaced by their absolute values (at 25 °C), as:…”

Section: Ph Metrymentioning

confidence: 99%

“…For pH metry, electrode potentials (silver chloride, calomel electrodes) and membrane potentials (glass electrode) are of interest. The Nernst equation is inappro priate for monocrystalline antimony elec trodes, since they do not yield one of the above-named potentials but a corrosive po tential [2],…”

mentioning

confidence: 99%

Electrochemical Aspects of pH Electrodes

Emde

1990

Dig Dis

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When a pH electrode is applied intragastrically for long-term pH metry, problems may occur which are related to the specific conditions of gastric juice and to the possible difference between the temperature of buffer solutions and the body temperature. The fact that pH electrodes measure the activity of the hydrogen ion instead of its concentration may, in concentrated solutions (i.e. pH < 2), lead to an error that is even compounded if other ions are present in high concentrations. This error normally does not influence comparisons between measurements obtained under the same conditions. It is, however, important to check which correction procedures are provided for the particular devices being used when comparing results obtained by different research groups. Calibration of the electrode at a temperature differing from body temperature may result in an important error. Complete correction for this error may be achieved for glass electrodes by a modified version of the Nernst equation; for monocrystalline antimony electrodes an empirically derived formula is available allowing for partial correction. In general, all types of electrodes should be calibrated using two different buffer solutions (one with a pH value between 6 and 8 and another with a pH of 2 or less) and the double-point interpolation method.

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On the use of monocrystalline antimony pH electrodes in gastro-oesophageal functional disorders

Cited by 41 publications

References 16 publications

pH Heterogeneity in Skeletal Muscle Extracellular Fluid

pH Heterogeneity in Skeletal Muscle Extracellular Fluid

Standardization of Electrode Positioning and Composition of Meals for Long-Term Intragastric pH Metry in Man

Electrochemical Aspects of pH Electrodes

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