The main goal of this work is to combine the usage of the numerical homogenization technique for determining the effective properties of representative volume elements with artificial neural networks. The effective properties are defined according to the classical laminate theory. The purpose is to create and train a rapid surrogate model for the quick calculation of the mechanical properties of hollow concrete slabs. First, the homogenization algorithm was implemented, which determines membrane, bending and transverse shearing properties of a given parametrized hollow-core precast slab reinforced with steel bars. The algorithm uses the finite element mesh but does not require a formal solution of the finite element method problem. Second, the learning and training artificial intelligence framework was created and fed with a dataset obtained by optimal Latin hypercube sampling. In the study, a multilayer perceptron type of artificial neural network was used. This allows for obtaining rapid calculations of the effective properties of a particular hollow-core precast slab by using a surrogate model. In the paper, it has been proven that such a model, obtained via complex numerical calculations, gives a very accurate estimation of the properties and can be used in many practical tasks, such as optimization problems or computer-aided design decisions. Above all, the efficient setup of the artificial neural network has been sought and presented.