On the use of ambulatory blood pressure recordings and insulin sensitivity measurements in support of the insulin-hypertension hypothesis

Nilsson, Peter M.; Lind, Lars; Andersson, P.; Hänni, Arvo; Berne, Christian; Baron, John A.; Lithell, Hans

doi:10.1097/00004872-199408000-00016

Cited by 23 publications

(11 citation statements)

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“…24,25 Therefore, fasting and postload hyper-insulinaemia, associated with normal and similar values of plasma glucose, can be considered a reliable index of insulin resistance. 25 ± 27 From our results, also taking into account the index of peripheral insulin activity, insulin sensitivity is reduced in both lean and obese normotensive adults with hypertensive parents compared with offspring of normotensives.…”

Section: Insulin Sensitivity In Obese Normotensives Am Grandi Et Almentioning

confidence: 99%

Insulin sensitivity in obese normotensive adults: influence of family history of hypertension

Grandi

Gaudio

Fachinetti³

et al. 1998

Int J Obes

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OBJECTIVE: To evaluate the in¯uence of family history of hypertension on insulin sensitivity in obese normotensive adults, comparing them with lean subjects. SUBJECTS: 136 normotensives (N)(mean 24 h blood pressure`130a80 mmHg; age range 35 ± 45 y): 32 lean (body mass index, BMI 25 kgam 2 ) N with normotensive parents (F7), 37 lean N with one or two parents hypertensive (F ), 32 obese (BMI ! 30 kgam 2 ) NF7 and, 35 obese NF . METHODS: 24 h ambulatory blood pressure monitoring; glucose, insulin and C-peptide before and 30, 60, 90 and 120 min after an oral glucose load; index of insulin peripheral activity (Ia: 10 4 ainsulin Â glucose values at glucose peak); fasting insulinaC-peptide ratio (IaCp). RESULTS: The four groups were comparable for age, gender and blood pressure values throughout the 24 h. Glucose, fasting and during test, and IaCp were similar among the four groups; insulin and C-peptide, fasting and stimulated, were signi®cantly higher and Ia lower in obese N than in lean N; at similar BMI, insulin and C-peptide were signi®cantly higher and Ia lower, in F than in F7. The correlation between insulin and BMI was signi®cantly closer in F7 than in F . CONCLUSIONS: Family history of hypertension appears to be signi®cantly associated with insulin sensitivity in both lean and obese normotensive adults; moreover, overweight and a genetic predisposition to hypertension may have additive adverse effects on insulin sensitivity in normotensive adult subjects.

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Section: Insulin Sensitivity In Obese Normotensives Am Grandi Et Almentioning

confidence: 99%

Insulin sensitivity in obese normotensive adults: influence of family history of hypertension

Grandi

Gaudio

Fachinetti³

et al. 1998

Int J Obes

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“…19 Moreover, the insulin sensitivity index obtained with the euglycaemic clamp and the 2-h insulin level of the OGTT were more closely related correlated to ambulatory blood pressure recordings than was the fasting insulin level. 20 With our small sample of a hypertensive population we found correlation between the daytime period and 24-h average ambulatory SBP and the area under the serum insulin curve. It is accepted nowadays that the area below the insulin profile during an OGTT is an index of pancreatic ␤-cell functioning and it is significantly correlated to insulin resistance in non-diabetic patients.…”

Section: Discussionmentioning

confidence: 63%

Insulin resistance and hypertension in postmenopausal women

Feldstein¹,

Akopian²,

Renauld³

et al. 2002

J Hum Hypertens

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The aim of the study was to elucidate the role of hyperinsulinaemia/insulin resistance in hypertension of lean postmenopausal women. Twenty-four women with essential hypertension (systolic/diastolic у140/90 mm Hg) and a body mass index (BMI) less than 26 kg/m 2 not receiving antihypertensive treatment or who had been without treatment for a 4-week washout period, and 10 normotensive postmenopausal weight-and aged-matched controls were compared. Both groups were not receiving hormone replacement therapy. Hip and waist circumferences were measured and waist/hip ratios were calculated. Casual blood pressure was measured in triplicate. Neither the fasting plasma glucose nor serum insulin levels in hypertensive women and normotensives differed significantly. During 2 h oral glucose (75 g)-tolerance test the mean plasma glucose levels after 30 min (172.5 ± 40.24 mg/dl vs 143.67 ± 20.16 mg/dl), 60 min (134.88 ± 38.78 mg/dl vs 112.33 ± 5.44 mg/dl) and 120 min (116.08 ± 26.65 mg/dl vs 95.56 ± 20.17 mg/dl) were significantly higher in hypertensives than that for normotensives (P Ͻ 0.05 for all three comparisons). The mean serum insulin levels of hypertensive women were significantly higher than that in normotensives after 15 min (92.04 ± 59.90 U/ml vs 54.89 ± 33.67 U/ml) and 120 min (49.63 ± 44.45 U/ml

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“…Other factors that may obscure these associations in the various studies are the use of concomitant antihypertensive treatment and the use of inadequate methods of insulin measurement, such as those presenting cross‐reactions with proinsulin. 2 Another parameter that is not appreciated and could be crucial for negative findings in some studies is the use of office readings for BP, as according to the findings of Narkiewicz et al 57 and Nilsson et al 58 the more precise the BP measurement method the closer the association of BP with insulin or IR.…”

Section: Discussionmentioning

confidence: 99%

Insulin Resistance, Hyperinsulinemia, and Hypertension: An Epidemiologic Approach

Sarafidis

Bakris

2006

J Cardiometabolic Synd

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During the past 2 decades, numerous experimental studies have provided solid evidence for the existence of several mechanisms connecting insulin resistance and hyperinsulinemia with blood pressure elevation, within the context of the cardiometabolic syndrome. In parallel, several groups have attempted to examine these associations from an epidemiologic perspective, but relevant findings were less consistent and not extensively discussed. Hyperinsulinemia has been associated with high blood pressure levels and hypertension development in cross-sectional, case-control, and prospective cohort studies. An association between insulin resistance and hypertension is also evident in existing studies, but prospective data on this relation are limited. Moreover, most of the evidence supporting close associations between these factors derives from Caucasian and Japanese populations, whereas data in other populations are not in agreement. This review summarizes and evaluates the relevant epidemiologic evidence to elucidate an important aspect of the relationship between hypertension and the cardiometabolic syndrome.

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On the use of ambulatory blood pressure recordings and insulin sensitivity measurements in support of the insulin-hypertension hypothesis

Cited by 23 publications

References 0 publications

Insulin sensitivity in obese normotensive adults: influence of family history of hypertension

Insulin sensitivity in obese normotensive adults: influence of family history of hypertension

Insulin resistance and hypertension in postmenopausal women

Insulin Resistance, Hyperinsulinemia, and Hypertension: An Epidemiologic Approach

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