On the Tuberculin Treatment of Bronchial Asthma and Hay Fever.

Vaccination strategies to reduce the risk of leukaemia and melanoma

“…12 More recently tuberculin positivity, indicative of exposure to mycobacterial antigens by BCG vaccination, infection with Mycobacterium tuberculosis or, possibly, sensitization to environmental mycobacteria, was shown to confer protection against atopic disorders in Japan. 13 This raises the question of whether natural infection by mycobacteria might contribute to immune maturation and protection against childhood leukaemia.…”

Vaccination Strategies to Reduce the Risk of Leukaemia and Melanoma

“…In addition, there are reports from the 1920s showing that, although patients with asthma or hayfever were often tuberculin positive, injections of small amounts of tuberculin appeared to be curative. 12 More recently tuberculin positivity, indicative of exposure to mycobacterial antigens by BCG vaccination, infection with Mycobacterium tuberculosis or, possibly, sensitization to environmental mycobacteria, was shown to confer protection against atopic disorders in Japan. 13 This raises the question of whether natural infection by mycobacteria might contribute to immune maturation and protection against childhood leukaemia.…”

On Alimentary Leucocytosis in Its Relation to the "Crise Hémoclasique" of Widal

“…Two of the present authors have been interested in the study of the causes and treatment of bronchial asthma. They found that in many cases of bronchial asthma and hay fever there seems to be a relation between hypersensitiveness to tuberculin and hypersensitiveness to the known or unknown causative agent of the acute attacks of asthma, and were able to prove that in many of these cases a cure or a considerable relief of the asthmatic symptoms could be obtained by desensitizing the patients to tuberculin by means of repeated injections of small doses of this (3). In the course of this work, however, they obtained the impression that in some of the asthma patients who were resistant to the tuberculin therapy the cause of the attacks of asthma • was to be looked for in the intestine, and later it appeared that in a number of other cases who were benefited by tuberculin treatment an intestinal factor also played an important part.…”