On the Systemic Mode of Action of Vitamin A

Ganguly, J.; Sarada, K; Jayaram, Makkuni; Joshi, Priyanka; Das, Rajesh; Murthy, S. K.; Thomas, Jenny; Bhargava, M.

doi:10.1159/000401301

Cited by 6 publications

(5 citation statements)

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“…Primary sperm defects originate during spermatogenesis and may be the result of genetic, environmental or nutritional factors (Barth & Oto, 1989). Several authors have associated a vitamin A deficiency with sperm alterations and a reduction in spermatogenesis (Johnson et al, 1970;Ganguly et al, 1980;Huang et al, 1983;Livera et al, 2000). A return to normal spermatogenesis after restoration of an adequate supply of vitamin A has been recorded.…”

Section: Discussionmentioning

confidence: 99%

Influence of nutrition on the quality of semen in Jaguars Panthera onca in Brazilian zoos

Paz¹,

Gonçalves²,

Carciofí

et al. 2006

International Zoo Yearbook

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In Brazilian zoos wild felids in captivity are generally fed meat. However, considering the basic nutritional needs of the domestic cat Felis catus, beef may be deficient in calcium, phosphorus, copper, manganese, vitamins A, D and E, thiamin, folic acid and biotin. The aim of this study was to determine the influence of vitamin (A, D, E, B1, B2, folic acid and biotin) and mineral (calcium, phosphorus, iron, copper, iodine and manganese) supplementation on the quality of semen in Jaguars Panthera onca. Between August 1998 and August 1999 eight adult ♂ Jaguars were offered red meat (beef) and bovine heart once a day. The vitamin/mineral supplementation used was based on the National Research Council recommendations for the domestic cat F. catus. Semen was collected by electroejaculation at the beginning of the trial and every 2 months thereafter for 1 year (n= 7 collection dates). Statistical analyses were performed using the Wilcoxon test (for motility, vigour and sperm concentration), the Friedman test (for sperm and testicular volume) and analysis of variance (for sperm morphology). There were no significant differences between collections for semen volume, concentration, motility and vigour (P>0·05) during the trial period. There was also no difference in morphology between samples with respect to secondary defects but the percentage of primary defects decreased (P<0·05) between the means of the third and the seventh collection series. The conclusion is that dietary supplementation with vitamins and minerals appears to decrease sperm abnormalities, improving seminal characteristics in the animals studied.

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Section: Discussionmentioning

confidence: 99%

Influence of nutrition on the quality of semen in Jaguars Panthera onca in Brazilian zoos

Paz¹,

Gonçalves²,

Carciofí

et al. 2006

International Zoo Yearbook

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“…Vitamin A was chosen to study ligand interactions with β-Lg because of its importance in a number of physiological functions in various mammal tissues. Vitamin A is essential for the stimulation of growth and proper development of tissues, for normal reproduction, for maintenance of rod vision, and for the differentiation of epithelial tissues. , Consequently, because humans are unable to synthesize vitamin A de novo, dietary lack of vitamin A leads to many clinical deficiency syndromes. Therefore, “vitamin A requirements” should be fulfilled by consumption of foods from vegetal sources containing provitamin A, β-carotene, β-cryptoxanthin, and α-carotene, or foods from animal sources containing preformed vitamin A, retinol and retinol esters. , …”

Section: Introductionmentioning

confidence: 99%

Interactions of β-Lactoglobulin Variants A and B with Vitamin A. Competitive Binding of Retinoids and Carotenoids

Mensi

Choiset

Rabesona

et al. 2013

J. Agric. Food Chem.

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β-Lactoglobulin (β-Lg) is the major whey protein of bovine milk present at a concentration of 2-3 g L(-1). Its biological role is still not well-known. However, many studies have suggested that β-Lg may play either nutritional or specific transporter role. The high affinity of β-Lg for retinol and other retinoids was reported. The results of interaction studies of β-Lg with carotenoids, that is, β-carotene, β-cryptoxanthin, and α-carotene, which display similar structures are reported in this study. The affinities of β-Lg for binding of retinoids and carotenoids were compared, providing more information about the binding site(s) of these molecules by β-Lg. Interactions were followed by the measurements of quenching of β-Lg tryptophan fluorescence and retinol fluorescence. The obtained results indicate that carotenoids are bound by β-Lg with high affinity of the order of 10(-8) M. Measurement of retinol competition with carotenoids for binding by β-Lg suggests that the binding of these two ligands occurs at two different sites of β-Lg.

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“…Subsequently, it was reported by Ganguly et al (1978) and by Das et al (1979) that the number of tubular gland cells is markedly less in such deficient oviducts. It was also reported by Ganguly et al (1978) that when the oviduct explants of immature chicks treated with oestrogen are incubated with [3H]thymidine in vitro, incorporation of the radioactive nucleoside is significantly lower in the tissue of the vitamin A-deprived chicks, compared with the corresponding vitamin A-repleted controls. The same workers have further shown that addition of retinol to the incubation medium restores the thymidine incorporation to near normal values in the deficient tissue, with retinol showing no such effects in the vitamin A-repleted tissue.…”

mentioning

confidence: 94%

“…Later by using oestrogeninduced development of the oviduct of immature chicks as a typical model system for rapid division and differentiation of cells, Joshi et al (1976) showed that the growth of the oviduct in terms of increase in net weight and also in DNA, RNA and protein contents is markedly less in the chicks deprived of vitamin A. Subsequently, it was reported by Ganguly et al (1978) and by Das et al (1979) that the number of tubular gland cells is markedly less in such deficient oviducts. It was also reported by Ganguly et al (1978) that when the oviduct explants of immature chicks treated with oestrogen are incubated with [3H]thymidine in vitro, incorporation of the radioactive nucleoside is significantly lower in the tissue of the vitamin A-deprived chicks, compared with the corresponding vitamin A-repleted controls.…”

mentioning

confidence: 99%

Isolation and characterization of binding proteins for retinol from the cytosol, nucleosol and chromatin of the oviduct magnum of laying hens

M¹,

Prasad²,

Padmanaban³

et al. 1979

Biochemical Journal

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Protein fractions that bind retinol were isolated from the cytosol, nucleosol and chromatin of the oviduct magnum of laying hens. The proteins isolated from the three sources showed similar elution profiles on chromatography through Sephadex G-75 and G-50 columns, and comparable mobility during electrophoresis on sodium dodecyl sulphate/polyacrylamide gels. Their molecular weights were calculated to be around 14500. When oviducts from vitamin A-depleted and vitamin A-repleted immature chicks given oestrogen injections for 6 consecutive days were incubated with [3H]retinyl acetate, uptake of the radioactivity in the nuclei of the vitamin A-depleted tissue was severalfold higher than that in the nuclei from the vitamin A-repleted tissue.

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On the Systemic Mode of Action of Vitamin A

Cited by 6 publications

References 0 publications

Influence of nutrition on the quality of semen in Jaguars Panthera onca in Brazilian zoos

Influence of nutrition on the quality of semen in Jaguars Panthera onca in Brazilian zoos

Interactions of β-Lactoglobulin Variants A and B with Vitamin A. Competitive Binding of Retinoids and Carotenoids

Isolation and characterization of binding proteins for retinol from the cytosol, nucleosol and chromatin of the oviduct magnum of laying hens

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