On the stability of shale: the role of zeta potential (ζ) and Debye Hückel length (κ<sup>−1</sup>) on shale swelling

Al-Bazali, Talal

doi:10.1080/10916466.2021.1981380

Cited by 7 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The osmotic hydration ability of shale was evaluated using the zeta potential test of the shale samples . The higher the zeta potential, the stronger the osmotic hydration ability. , The experimental process of the zeta potential test was carried out according to the industry standard of the People’s Republic of China, “zeta potential analysis of colloidal particles-general principles of electrophoresis (GB/T 32668-2016)”, which consisted of the following three steps: (1) Sample preparation.…”

Section: Methodsmentioning

confidence: 99%

Investigation of the Mechanism and Effect of Citric Acid-Based Deep Eutectic Solvents Inhibiting Hydration and Expansion of Gas Shale Clay Minerals

et al. 2023

View full text Add to dashboard Cite

This study developed a shale hydration inhibitor using a citric acid-based deep eutectic solvent (Cit-DES) and hexadecylammonium bromide (cetyltrimethylammonium bromide) to aid wellbore instability and collapse caused by drilling of shale gas wells with water-based drilling fluids. Soaking and linear expansion experiments were conducted with Na-bent and Longmaxi formation shale, respectively. The changes in illite interlayer spacing, wettability, and water absorption capacity of shale samples before and after soaking in an inhibitor solution were evaluated, which indicated that the inhibitor reduced shale hydration. The results showed that the inhibitor effectively inhibits the osmotic and surface hydration of the shale. Due to the Cit-DES hydrogen bond, the inhibitor is firmly adsorbed on the shale pore wall and inserted between clay minerals, reducing the shale surface energy, hydrophilicity, and surface potential. The swelling expansion rate of shale inhibitors is only 38.9% compared to a 3% KCl solution. The amount of shale imbibition per unit mass in distilled water is 0.011 g/g. In the inhibitor, the imbibition mass per unit of shale is 0.002 g/g, which is only 23.68% of that in distilled water. The inhibitor is environment-friendly and has a broad application prospect for maintaining shale wellbore stability and preventing wellbore collapse during horizontal shale drilling operations.

show abstract

Section: Methodsmentioning

confidence: 99%

Investigation of the Mechanism and Effect of Citric Acid-Based Deep Eutectic Solvents Inhibiting Hydration and Expansion of Gas Shale Clay Minerals

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The prepared nanoparticles (CNB-PLGA-PSar-NPs) were measured using DelsaNano C (Beckman Coulter, USA) for particle size, polydispersity index (PDI), and zeta potential ( 29 – 31 ). Photon correlation spectroscopy is the name of the fundamental concept behind this instrument.…”

Section: Methodsmentioning

confidence: 99%

Unveiling the therapeutic potential of cabozantinib-loaded poly D,L-lactic-co-glycolic acid and polysarcosine nanoparticles in inducing apoptosis and cytotoxicity in human HepG2 hepatocellular carcinoma cell lines and in vivo anti-tumor activity in SCID female mice

Bhattacharya

Parihar²,

Prajapati³

2023

Front. Oncol.

View full text Add to dashboard Cite

IntroductionThe study aimed to develop a nano-based drug delivery system for the treatment of hepatocellular carcinoma (HCC), a type of liver cancer that accounts for 90% of all liver malignancies. The study focused on the use of cabozantinib (CNB), a potent multikinase inhibitor that targets the VEGF receptor 2, as the chemotherapeutic drug. We developed CNB-loaded nanoparticles made from Poly D, L-lactic-co-glycolic acid, and Polysarcosine (CNB-PLGA-PSar-NPs) for use in human HepG2 cell lines.MethodsBy O/W solvent evaporation method, the polymeric nanoparticles were prepared. The various techniques, such as photon correlation spectroscopy, scanning electron microscopy, and transmission electron microscopy were used, to determine the formulation's particle size, zeta potential, and morphology. SYBR Green/ROX qPCR Master Mix and RT-PCR equipment used to measure liver cancer cell line and tissue mRNA expression and MTT assay to test HepG2 cell cytotoxicity. Cell cycle arrest analysis, annexin V assay, and ZE5 Cell Analyzer apoptosis assay were also performed.ResultsThe results of the study showed that the particle diameters were 192.0 ± 3.67 nm with 0.128 PDI and -24.18 ± 3.34 mV zeta potential. The antiproliferative and proapoptotic effects of CNB-PLGA-PSar-NPs were evaluated using MTT and flow cytometry (FCM). The IC50 value of CNB-PLGA-PSar-NPs was 45.67 µg/mL, 34.73 µg/mL, and 21.56 µg/mL for 24, 48, and 72 h, respectively. The study also found that 11.20% and 36.77% of CNB-PLGA-PSar-NPs-treated cells were apoptotic at 60 µg/mL and 80 µg/mL, respectively, suggesting that the nanoparticles were effective in inducing apoptosis in the cancer cells. It can also conclude that, CNB-PLGA-PSar-NPs inhibit human HepG2 hepatocellular carcinoma cells and kill them by upregulating the tumour suppressor genes MT1F, MT1X, and downregulating MTTP, APOA4. Further in vivo antitumor activity was well reported in SCID female mice.DiscussionOverall, this study suggests that the CNB-PLGA-PSar-NPs are a promising drug delivery system for the treatment of HCC, and further research is needed to investigate their potential in clinical treatment.

show abstract

“…It is vital to point out that this method allows us to measure shale swelling and simultaneously estimate the amount of water and ions exchanged between the shale sample and the salt solution. This technique makes shale swelling investigation more applicable especially since shale's swelling is argued to be extremely connected with water and ions transport in or out of shale [39][40][41].…”

Section: Experimental Methodsmentioning

confidence: 99%

Reliability of chemical osmosis as a practical method to extract water out of shale and promote shale’s mechanical stability

2023

JOGRR

View full text Add to dashboard Cite

Wellbore instability in shale formations is one of the most bothersome problems leading to significant changes in shale’s petrophysical, mechanical, and chemical properties, and could cost billions of dollars annually. Drilling fluid’s ionic composition is one of the factors affecting wellbore stability. This paper investigates the impact of chemical osmosis, ionic diffusion, and diffusion osmosis on the stability of shale, identify the critical salt concentration, and examine the impact of ionic type and concentration on shale stability. Experimental methods include utilization of shale I and II through linear expansion and gravimetric measurement tests using different salts. Results show that the critical salt concentration in shale I and II is 8 w/w%. Chemical osmosis is found to be a reliable method for water extraction out of shale if critical concentration value is not surpassed. Beyond this value, the ionic diffusion and diffusion osmosis in shale I and II were adversely affecting shale’s mechanical and chemical stability. The swelling and gravimetric ions and water uptake tests showed that shale is a leaky semi-permeable membrane, and that chemical osmosis could be jeopardized by ionic transport into shale. However, the water transport impact on changes in the thickness of diffuse double layer of clay needs to be investigated. The impact of temperature on water and ions transportation into shale needs to be examined to reflect in-situ conditions. In this study, the cation type that makes up the salt was varied while the anion type was fixed. Since both cations and anions tend to diffuse into shale in the presence of a concentration gradient, it is recommended to vary the anion type to study the combined impact of cation and anion type on shale stability.

show abstract

On the stability of shale: the role of zeta potential (ζ) and Debye Hückel length (κ⁻¹) on shale swelling

Cited by 7 publications

References 27 publications

Investigation of the Mechanism and Effect of Citric Acid-Based Deep Eutectic Solvents Inhibiting Hydration and Expansion of Gas Shale Clay Minerals

Investigation of the Mechanism and Effect of Citric Acid-Based Deep Eutectic Solvents Inhibiting Hydration and Expansion of Gas Shale Clay Minerals

Unveiling the therapeutic potential of cabozantinib-loaded poly D,L-lactic-co-glycolic acid and polysarcosine nanoparticles in inducing apoptosis and cytotoxicity in human HepG2 hepatocellular carcinoma cell lines and in vivo anti-tumor activity in SCID female mice

Reliability of chemical osmosis as a practical method to extract water out of shale and promote shale’s mechanical stability

Contact Info

Product

Resources

About

On the stability of shale: the role of zeta potential (ζ) and Debye Hückel length (κ−1) on shale swelling

Cited by 7 publications

References 27 publications

Investigation of the Mechanism and Effect of Citric Acid-Based Deep Eutectic Solvents Inhibiting Hydration and Expansion of Gas Shale Clay Minerals

Investigation of the Mechanism and Effect of Citric Acid-Based Deep Eutectic Solvents Inhibiting Hydration and Expansion of Gas Shale Clay Minerals

Unveiling the therapeutic potential of cabozantinib-loaded poly D,L-lactic-co-glycolic acid and polysarcosine nanoparticles in inducing apoptosis and cytotoxicity in human HepG2 hepatocellular carcinoma cell lines and in vivo anti-tumor activity in SCID female mice

Reliability of chemical osmosis as a practical method to extract water out of shale and promote shale’s mechanical stability

Contact Info

Product

Resources

About

On the stability of shale: the role of zeta potential (ζ) and Debye Hückel length (κ⁻¹) on shale swelling