As medical technology advances, there is an increasing need for healthcare providers all over the world to securely share a growing volume of data. Blockchain is a powerful technology that allows multiple parties to securely access and share data. Given the enormous challenge that healthcare systems face in digitizing and sharing health records, it is not unexpected that many are attempting to improve healthcare processes by utilizing blockchain technology. By systematically examining articles published from 2017 to 2022, this review addresses the existing gap by methodically discussing the state, research trends, and challenges of blockchain in medical data exchange. The number of articles on this issue has increased, reflecting the growing importance and interest in blockchain research for medical data exchange. Recent blockchain-based medical data sharing advances include safe healthcare management systems, health data architectures, smart contract frameworks, and encryption approaches. The evaluation examines medical data encryption, blockchain networks, and how the Internet of Things (IoT) improves hospital workflows. The findings show that blockchain can improve patient care and healthcare services by securely sharing data.