On the role of survivin as a stem cell biomarker of canine hair follicle and related tumours

Bongiovanni, Laura; Diodoro, F. Di; Salda, Leonardo Della; Brachelente, Chiara

doi:10.1111/vde.12114

Cited by 7 publications

(6 citation statements)

References 12 publications

(27 reference statements)

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“…Interestingly, survivin, a member of the inhibitor of apoptosis proteins associated with tumor initiation and progression and maintenance of stem cells, 41 showed partial co-localization with CK15 in trichoepitheliomas and trichoblastomas, suggesting a role for survivin in the maintenance of cancer stem cells in these HF tumors. 5…”

Section: Hair Follicle Neoplasms and Stem Cellsmentioning

confidence: 99%

Histologic features of hair follicle neoplasms and cysts in dogs and cats: a diagnostic guide

Wiener

2021

J VET Diagn Invest

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Hair follicle neoplasms occur in many different species, including humans. In domestic animals, they are most common in dogs. Most hair follicle tumors are benign, but malignant neoplasms can also occur. To diagnose hair follicle neoplasms, a thorough knowledge of follicular anatomy is important, given that follicular tumors are classified according to the differentiation pattern seen in the corresponding part of the normal hair follicle. This review focuses on the key diagnostic features of hair follicle tumors and follicular cysts in dogs and cats.

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Section: Hair Follicle Neoplasms and Stem Cellsmentioning

confidence: 99%

Histologic features of hair follicle neoplasms and cysts in dogs and cats: a diagnostic guide

Wiener

2021

J VET Diagn Invest

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“…At present, Survivin has gained marked interest in the field of tumor research. The protein is tumor specific, which means that it is only expressed in tumor and embryonic tissues, and is closely associated with tumor differentiation, proliferation, invasion and metastasis (20,21). The expression of the Survivin gene has been identified to be upregulated in nasal type natural killer (NK)/T cell lymphoma cells and has been found to be significantly correlated with the expression of p53 and B cell lymphoma 2 proteins.…”

Section: Discussionmentioning

confidence: 99%

Expression of p16 and Survivin in gliomas and their correlation with cell proliferation

Gao

Song

2015

Oncology Letters

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Abstract. The survival rate of glioma patients is very low, and a lack of effective diagnostic techniques are available at present. The current study aimed to investigate the expression of p16 and Survivin and their association with proliferation and apoptosis in gliomas, as well as patient characteristics and prognosis. In total, 62 glioma specimens were surgically resected and pathologically confirmed at the Zhumadian Central Hospital (Zhumadian, China) between June 2008 and February 2014. Clinical data, including the gender and age of the patients, as well as the location, infiltration degree, size and pathological stage of the glioma, was collected. In order to evaluate the expression of p16 and Survivin in the gliomas, the Ki-67 labeling index was used to evaluate cell proliferation activity. The number of argyrophilic nucleolar organizer regions and the rate of cellular apoptosis was examined using the terminal deoxynucleotidyl transferase dUTP nick end labeling method. The results were analyzed using SPSS 14.0 statistical software. The positive rate of p16 gene expression in the gliomas was 46.77% (29 cases), and p16 gene expression was positively correlated with the differentiation status, tumor size and pre-operative symptoms. The positive rate of Survivin expression in the gliomas was 69.88% (58 cases), and Survivin expression was positively correlated with tumor size, differentiation status and clinical stage. The proliferation activity of the gliomas was enhanced with increasing p16 and Survivin expression, while apoptosis was inhibited. In conclusion, the overexpression of p16 and Survivin was closely associated with uncontrolled cell proliferation and the inhibition of apoptosis in gliomas. The combined analysis of the expression of p16 and Survivin in gliomas may provide guidance with respect to the clinical diagnosis, evaluation, treatment and prognosis of patients with glioma.

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“…This study also demonstrated that survivin expression was downregulated by CUR and CUR + BUS (Figures 5(a) and 5(b) ; Table 1 ). Survivin is an important IAP that tends to be overexpressed in cancer cells [ 51 ], including cancer stem cells [ 52 , 53 ], which exerts antiapoptotic effects via various mechanisms. For example, survivin inhibits caspase-dependent apoptosis through cooperation with XIAP, inhibits the SMAC-XIAP complex, and interferes with caspase-3/caspase-9 [ 51 ] ( Figure 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…CUR alone and especially CUR + BUS decreased survivin expression in KG1a cells (consistent with the results of apoptosis showed in Figures 3(a) and 3(b) ). Growing evidence has demonstrated that downregulating or inhibiting survivin could induce apoptosis and eradicate cancer stem cells or LSCs [ 52 , 54 – 56 ]. This suggests that CUR may induce apoptosis and enhance BUS-induced apoptosis by downregulating the expression of survivin in KG1a cells.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Enhanced Busulfan-Induced Apoptosis through Downregulating the Expression of Survivin in Leukemia Stem-Like KG1a Cells

Weng

Zeng

Huang

et al. 2015

BioMed Research International

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Leukemia relapse and nonrecurrence mortality (NRM) due to leukemia stem cells (LSCs) represent major problems following hematopoietic stem cell transplantation (HSCT). To eliminate LSCs, the sensitivity of LSCs to chemotherapeutic agents used in conditioning regimens should be enhanced. Curcumin (CUR) has received considerable attention as a result of its anticancer activity in leukemia and solid tumors. In this study, we investigated the cytotoxic effects and underlying mechanisms in leukemia stem-like KG1a cells exposed to busulfan (BUS) and CUR, either alone or in combination. KG1a cells exhibiting BUS-resistance demonstrated by MTT and annexin V/propidium iodide (PI) assays, compared with HL-60 cells. CUR induced cell growth inhibition and apoptosis in KG1a cells. Apoptosis of KG1a cells was significantly enhanced by treatment with CUR+BUS, compared with either agent alone. CUR synergistically enhanced the cytotoxic effect of BUS. Seven apoptosis-related proteins were modulated in CUR- and CUR+BUS-treated cells analyzed by proteins array analysis. Importantly, the antiapoptosis protein survivin was significantly downregulated, especially in combination group. Suppression of survivin with specific inhibitor YM155 significantly increased the susceptibility of KG1a cells to BUS. These results demonstrated that CUR could increase the sensitivity of leukemia stem-like KG1a cells to BUS by downregulating the expression of survivin.

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On the role of survivin as a stem cell biomarker of canine hair follicle and related tumours

Abstract: These findings suggest that survivin could play an important role in the maintenance of the hair follicle cycle as well as in tumour initiation and maintenance of cancer stem cells.

Cited by 7 publications

References 12 publications

Histologic features of hair follicle neoplasms and cysts in dogs and cats: a diagnostic guide

Histologic features of hair follicle neoplasms and cysts in dogs and cats: a diagnostic guide

Expression of p16 and Survivin in gliomas and their correlation with cell proliferation

Curcumin Enhanced Busulfan-Induced Apoptosis through Downregulating the Expression of Survivin in Leukemia Stem-Like KG1a Cells

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