On the role of serotonin and effort in voluntary attention: Evidence of genetic variation in N1 modulation

Enge, Sören; Fleischhauer, Monika; Lesch, Klaus‐Peter; Strobel, Alexander

doi:10.1016/j.bbr.2010.07.021

Cited by 48 publications

(29 citation statements)

References 55 publications

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“…In the low-anxiety group, genetic differences were at the forefront. It should also be noted that this study [6] also showed a relationship between the genetic variant of the serotonin transporter and the amplitude of the N100 wave in response to the target stimulus (the parameters of the N100 wave were not discussed in this report), and no mediating influence was seen for the effects of emotional characteristics (neuroticization) on the amplitude of the wave. Similarly, in the present studies we did not see any link between polymorphism of the BDNF gene and anxiety with the parameters of the N100 wave in relationships to the target stimulus.…”

Section: Effects Of the Interaction Between The Level Of Anxiety And mentioning

confidence: 76%

“…Subjects presumably experience the greatest feelings of uncertainty and agitation at this stage of information processing. At the same time, the amplitude of the N100 wave depends on the motivational significance of the stimulus and correlates with the level of cognitive effort applied [6]. Given this, the effect of anxiety on the link between the BDNF gene and the amplitude of N100 may reflect the fact that people with high levels of anxiety make greater efforts to solve tasks correctly, such that the effect of the "risk allele", i.e., a decrease in amplitude, is eliminated.…”

Section: Effects Of the Interaction Between The Level Of Anxiety And mentioning

confidence: 98%

“…Emotions, especially negative emotions, affect basal cognitive processes, though their role has generally not been considered in molecular-genetic experiments. We are aware of only one study [6] in which the mediating role of emotional characteristics in the association between a molecular-genetic marker and cognitive functioning was investigated. This study addressed the relationship between polymorphism of the 5-HTTLPR serotonin transporter gene and measures of auditory event-related potentials in mentally healthy people.…”

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confidence: 99%

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Effects of the Interaction Between the Level of Anxiety and the Val66Met Polymorphism of the Brain-Derived Neurotrophic Factor Gene on Attention in Patients with Schizophrenia Spectrum Disorders

Golimbet

Лебедева

Алфимова

et al. 2015

Neurosci Behav Physi

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Impairments to cognitive functioning are regarded as one of the most important manifestations of schizophrenia, the pathogenesis of which involves a leading role for genetic factors. The search for genes associated with the severity of neurocognitive deficit in schizophrenia patients is therefore of significant interest. Important advances have been made in this area in recent times. Associations have been seen between polymorphous sites (polymorphisms) in several genes and cognitive measures assessed using a variety of different approaches, particularly changes in brain ERP (event-related potentials) and the efficiency of task performance [3]. However, these associations have not always been confirmed in repeat experiments, pointing to a potential mediating role for other factors. These may include the emotional characteristics of the subjects. Emotions, especially negative emotions, affect basal cognitive processes, though their role has generally not been considered in molecular-genetic experiments. We are aware of only one study [6] in which the mediating role of emotional characteristics in the association between a molecular-genetic marker and cognitive functioning was investigated. This study addressed the relationship between polymorphism of the 5-HTTLPR serotonin transporter gene and measures of auditory event-related potentials in mentally healthy people. The personality characteristics of the subjects linked with negative emotionality were assessed, particularly the degree of neuroticism, which was measured using the NEO-PI personality questionnaire.The effects of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene and levels of trait anxiety (negative emotionality) on attention were studied in 90 patients with schizophrenia and schizoaffective psychosis. Attention was evaluated using auditory event-related potentials (ERP) and neuropsychological testing. Genotype was found to have a significant effect (anxiety was not) on the efficiency of performing the neuropsychological test on attention and the amplitude of the ERP P300 wave in the frontal and temporal leads. Carriers of the Met allele has poorer performance of the attention task than subjects with the ValVal genotype, and also showed a lower P300 wave amplitude. Genotype combined with the level of anxiety was found to affect the N100 wave in response to the non-significant stimulus, significant differences being seen only in the group with a low level of anxiety: the Met allele was associated with lower N100 amplitudes. Among patients with high levels of anxiety, N100 wave amplitude was independent of the BDNF gene variant present. It is suggested that people with high levels of anxiety expend more effort to solve the task correctly at the early stages of signal recognition, the amplitudedecreasing effect of the "risk allele" being eliminated.

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Section: Effects Of the Interaction Between The Level Of Anxiety And mentioning

confidence: 76%

Section: Effects Of the Interaction Between The Level Of Anxiety And mentioning

confidence: 98%

mentioning

confidence: 99%

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Effects of the Interaction Between the Level of Anxiety and the Val66Met Polymorphism of the Brain-Derived Neurotrophic Factor Gene on Attention in Patients with Schizophrenia Spectrum Disorders

Golimbet

Лебедева

Алфимова

et al. 2015

Neurosci Behav Physi

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“…First, an important consideration in the interpretation of behavioral phenotypes in mice bearing constitutive null mutations is the possibility that they can reflect the effects of the mutation on brain development. In accord with this possibility, a large body of evidence indicates that genetic perturbations of components of the serotonin system are associated with impaired executive function (Chamberlain et al, 2006;Cools et al, 2008;Enge et al, 2011;Angoa-Perez et al, 2012). Second, in the pharmacological studies, drugs are typically administered after task acquisition had been performed in untreated animals.…”

Section: Discussionmentioning

confidence: 99%

Impact of Serotonin (5-HT)2C Receptors On Executive Control Processes

Pennanen

Hart

et al. 2012

Neuropsychopharmacol

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Although the serotonin (5-hydroxytryptamine, 5-HT) neurotransmitter system has been implicated in modulating executive control processes such as attention, response inhibition, and behavioral flexibility, the contributions of particular serotonin receptors remain unclear. Here, using operant-based behavioral paradigms, we demonstrate that mice with genetically ablated 5-HT 2C receptors (2CKO mice) display deficits in executive functions. 2CKO mice were impaired in the acquisition of a visuospatial attention task as assessed in the 5-choice serial reaction time task (5-CSRTT). In this task, 2CKO mice exhibited marked impairment of attentional processes, with normal response inhibition. We assessed dynamic changes in neurotransmitter levels within the nucleus accumbens (NAc) by in vivo microdialysis in task-performing animals. Extracellular dopamine concentrations were elevated in the NAc of 2CKO mice during task performance, indicating that 5-HT 2C receptors impact dopamine homeostasis during a visuospatial attention task. These findings raise the possibility that disinhibition of mesolimbic dopamine pathways contributes to impaired attention and perturbed task performance in 2CKO mice. Additionally, in a spatial reversal learning task, 2CKO mice failed to improve their performance over a series of reversals, indicating that intact 5-HT 2C receptor signaling is required to accurately respond to repeated changes in reward contingencies. In contrast to the 2CKO phenotype in the 5-CSRTT, wild-type mice treated with the 5-HT 2C receptor antagonist SB242084 exhibited diminished response inhibition, suggesting differing effects of acute pharmacological blockade and constitutive loss of 5-HT 2C receptor activity. Altogether, these findings provide insights into the serotonergic regulation of executive control processes and suggest that impaired 5-HT 2C receptor signaling during development may predispose to executive function disorders.

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“…These psychological differences between high and low NFC individuals may map onto (neuro)cognitive process of automatic sensory gating control on a very early sensory stage of stimuli processing [8]. We assume that the NFC, as a motivation to reduce uncertainty, is associated with an increased influence of the goal-driven attentional system.…”

Section: Introductionmentioning

confidence: 99%

Electrocortical indices of attention correlate with the need for closure

Kossowska

Czarnek²,

Wyczesany³

et al. 2015

NeuroReport

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Need for closure (NFC), defined as a desire for a quick and unambiguous answer to a question and an aversion to uncertainty, usually leads to a more structured, persistent, and rigid cognitive style. We suggested that this cognitive characteristic could be related to differences in a simple sensory gating control mechanism as reflected in event-related potentials (N1 component). We expected that the higher an individual's NFC, the more attention he/she would allocate to the selected stimuli or the feature of the stimuli, which is manifested in an increased N1 component. We tested this assumption in two experiments where NFC was measured by a scale and event-related potentials were recorded during the Stroop task and the Visual Distractor task. In line with the hypotheses, we found that NFC was associated with amplified processing of stimuli at an early sensory stage, which was evidenced in an increased N1 component. We suggested that this early sensory gating mechanism protects high NFC individuals against anxiety-producing uncertainty.

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On the role of serotonin and effort in voluntary attention: Evidence of genetic variation in N1 modulation

Cited by 48 publications

References 55 publications

Effects of the Interaction Between the Level of Anxiety and the Val66Met Polymorphism of the Brain-Derived Neurotrophic Factor Gene on Attention in Patients with Schizophrenia Spectrum Disorders

Effects of the Interaction Between the Level of Anxiety and the Val66Met Polymorphism of the Brain-Derived Neurotrophic Factor Gene on Attention in Patients with Schizophrenia Spectrum Disorders

Impact of Serotonin (5-HT)2C Receptors On Executive Control Processes

Electrocortical indices of attention correlate with the need for closure

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