By modifying Ghahramany’s integrated nuclear binding energy formula with strong and weak interactions, it is possible to approximate the nuclear binding energy of isotopes with one unique energy coefficient and four terms. Considering even-odd corrections, shell corrections and other microscopic corrections, it seems possible to improve the accuracy with a clear physical basis. Based on our recent work and the proposed formula, we are very confident to say that, electroweak interaction plays a vital role in fixing the nuclear binding energy.