On the role of membrane embedding, protein rigidity and transmembrane length in lipid membrane fusion

Abstract

The fusion of biological membranes is ubiquitous in natural processes like exo- and endocytosis, intracellular trafficking and viral entry. Membrane fusion is also utilized in artificial biomimetic fusion systems, e.g....

Protein-Mediated Changes in Membrane Fluidity and Ordering: Insights into the Molecular Mechanism and Implications for Cellular Function

“…This study can be helpful for understanding membrane fusion, lipid− protein complex formation, intercalation of the protein into the biological membranes, and the role of interfacial water in mediating these interactions. 46,47 To gain deeper insights into the effect on membrane fluidity, we have probed the interaction of HSA at pH 3.5 with the dDPPG monolayer. The VSFG spectra of interaction of the protein with dDPPG lipid are shown in Figure 2a−c at different surface pressures.…”

“…The spectral response of lipid C–D signals at different surface pressures is shown in Figure S1. This study can be helpful for understanding membrane fusion, lipid–protein complex formation, intercalation of the protein into the biological membranes, and the role of interfacial water in mediating these interactions. , …”