On the role of fibronectin during the compaction stage of somitogenesis in the chick embryo

Lash, James W.; Seitz, Anna W.; Cheney, Clarissa M.; Ostrovsky, David

doi:10.1002/jez.1402320207

Cited by 50 publications

(29 citation statements)

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“…Only the more mature segmental plate cells react to the peptide. This suggestion is supported by the finding of an antero-posterior diminishing gradient of fibronectin along the segmental plate (Ostrovsky et al, 1983;Lash et al, 1984) and an increase in cell-cell adhesion between the anterior segmental plate cells (Bellairs et al, 1978;Cheney and Lash, 1984). Further evidence for anterior-posterior differences was reported by George-Weinstein et al (1994) who found that segmental plate cells undergo an increasing ability to differentiate with a n increased residence time in the mesodermal layer after gastrulation.…”

Section: Discussionmentioning

confidence: 90%

Posterior extension of the chick nephric (Wolffian) duct: The role of fibronectin and NCAM polysialic acid

Bellairs

Lear

Yamada

et al. 1995

Developmental Dynamics

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Section: Discussionmentioning

confidence: 90%

Posterior extension of the chick nephric (Wolffian) duct: The role of fibronectin and NCAM polysialic acid

Bellairs

Lear

Yamada

et al. 1995

Developmental Dynamics

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“…46 Somitogenesis in the chick embryo also involves an FN-dependent event in which presomitic cells in the segmental plate undergo compaction. 47 Thus, strong tissue cohesion can be brought about not only through direct cell-cell interactions, as mediated by cadherins, but also indirectly via integrin-ECM interactions.…”

Section: Discussionmentioning

confidence: 99%

Biophysical measurement of brain tumor cohesion

Winters¹,

Shepard²,

Foty

2004

Intl Journal of Cancer

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An advantage of using 3D multicellular spheres to study tumor biology is that they better approximate the interactions encountered by cells in vivo. Our previous studies have shown that the process of spheroid formation is governed by the same thermodynamic principles driving the formation of liquid droplets. This liquid-like behavior enables us to measure a key property influencing tumor behavior, namely, intercellular cohesion. We have developed a method, tissue surface tensiometry (TST), to measure the cohesivity, expressible as surface tension (), of tissue aggregates under physiologic conditions. This study utilizes TST to measure the cohesivity of 3 widely used malignant astrocytoma cell lines of different in vitro invasive potentials. We compare invasiveness with aggregate cohesivity and with the expression of N-cadherin, a key mediator of cell-cell cohesion in neural tissues. We show that the cell lines exhibit liquid-like behavior since they form spheroids whose surface tension is both force-and volumeindependent; that aggregates from each cell line have a distinct surface tension that correlates with their in vitro invasive capacity; that dexamethasone (Dex), a widely used therapeutic agent for the treatment of tumor-related cerebral edema, increases aggregate cohesivity and decreases invasiveness; that dexamethasone treatment decreases invasion in a dose-dependent manner but only when cells are in direct contact with one another; and that dexmediated decreased invasiveness correlates with increased aggregate cohesivity as measured by TST but not with N-cadherin expression or function. Our results demonstrate that for these cell lines, cohesivity is an excellent predictor of in vitro invasiveness. © 2004 Wiley-Liss, Inc. Key words: tissue surface tensiometry; malignant astrocytoma; cohesivity; invasion; dexamethasone Glioblastoma multiforme (GBM) represent approximately 60% of all gliomas and 30% of all intracranial tumors. 1 The hallmark of these aggressive tumors is their ability to invade the brain rapidly. Typically, at the time of diagnosis, tumor cells have already spread at least 2 cm beyond the main tumor mass. This rapid local invasion, along with their intrinsic resistance to radiation and chemotherapy, is one of the key factors in primary brain tumor resistance to current forms of therapy. Unfortunately, the current system of histopathologic staging provides a poor approximation of the behavior of an individual tumor. Some histologically lowgrade tumors rapidly invade the brain, while some tumors graded histologically as aggressive do not behave as aggressively as their histology would predict. Newer molecular classifications of brain tumors as yet have failed to provide a more accurate prediction of tumor behavior.Molecular mechanisms underlying malignant brain tumor invasion have been intensively studied over the last 20 years. Many factors have been identified as either facilitators or inhibitors of brain tumor invasion, including cytokines, 2 lymphokines, 3 adhesion molecules, 4 growt...

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“…The formation of somites is obviously dependent on increased cell adhesion between the cells at the rostral end of the presomitic mesoderm as compared to cells located further caudally (Bellairs et al, 1978;Cheney and Lash, 1984;Lash et al, 1984). It has been shown that the expression of both the calcium-dependent adhesion molecule N-cadherin, and the neural cell adhesion molecule (NCAM), is upregulated just before somite formation (Hall and Miyake, 1992).…”

Section: B Cell Adhesion-mentioning

confidence: 99%

“…Components-Fibronectin is a major component of the extracellular matrix and long been implicated in the epithelialization of somites Lash et al, 1984). For example, addition of fibronectin or a peptide corresponding to the cellular recognition site of fibronectin can stimulate aggregation of disaggregated paraxial mesoderm cells in vitro Lash et al, 1984).…”

Section: C Extracellular Matrixmentioning

confidence: 99%

“…For example, addition of fibronectin or a peptide corresponding to the cellular recognition site of fibronectin can stimulate aggregation of disaggregated paraxial mesoderm cells in vitro Lash et al, 1984). Targeted disruption of the fibronectin gene leads to mesodermal defects during gastrulation and embryonic lethality after day 9 (George et al, 1993).…”

Section: C Extracellular Matrixmentioning

confidence: 99%

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Molecular basis for skeletal variation: insights from developmental genetic studies in mice

Kappen

Neubüser

Balling

et al. 2007

Birth Defects Research Pt B

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Skeletal variations are common in humans, and potentially are caused by genetic as well as environmental factors. We here review molecular principles in skeletal development to develop a knowledge base of possible alterations that could explain variations in skeletal element number, shape or size. Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development. Birth Defects Res (Part B), 80:425–450, 2007. © 2007 Wiley‐Liss, Inc.

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On the role of fibronectin during the compaction stage of somitogenesis in the chick embryo

Cited by 50 publications

References 13 publications

Posterior extension of the chick nephric (Wolffian) duct: The role of fibronectin and NCAM polysialic acid

Posterior extension of the chick nephric (Wolffian) duct: The role of fibronectin and NCAM polysialic acid

Biophysical measurement of brain tumor cohesion

Molecular basis for skeletal variation: insights from developmental genetic studies in mice

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