We study the generalized χ and η cross-helicities for non-ideal non-barotropic magnetohydrodynamics (MHD). χ and η, the additional label translation symmetry group, are used to generalize cross-helicity in ideal flows. Both new helicities are additional topological invariants of ideal MHD. To study there behavior in non-ideal MHD, we calculate the time derivative of both helicities using non-ideal MHD equations in which viscosity, finite resistivity, and heat conduction are taken into account. Physical variables are divided into ideal and non-ideal quantities separately during the mathematical analysis for simplification. The analytical results indicate that χ and η cross-helicities are not strict constants of motion in non-ideal MHD and show a rate of dissipation that is comparable to the dissipation of other topological constants of motion.